WormBase Tree Display for Gene: WBGene00006845

WBGene00006845 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F11C3
  Identity: Version: 1
    Name: CGC_name: unc-122 Person_evidence: WBPerson261
      Sequence_name: F11C3.2
      Molecular_name: F11C3.2
        F11C3.2.1
        CE51321
      Other_name: ofm-1
        cof-1 CGC_data_submission
        CELE_F11C3.2 Accession_evidence: NDB BX284601
      Public_name: unc-122
    DB_info: Database: AceView gene 1P467
        WormQTL gene WBGene00006845
        WormFlux gene WBGene00006845
        NDB locus_tag CELE_F11C3.2
        Panther gene CAEEL|WormBase=WBGene00006845|UniProtKB=G5EGP1
          family PTHR23192
        NCBI gene 173359
        RefSeq protein NM_001322696.3
        TrEMBL UniProtAcc G5EGP1
        UniProt_GCRP UniProtAcc G5EGP1
        OMIM gene 608603
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Allele (81)
    Possibly_affected_by: WBVar02158832
    Legacy_information: [C.elegansII] e2520 : medium coiler at all stages. Moves forward well when stimulated, tends to coil up when moving backwards or at rest. Coiling usually ventral, occasionally dorsal. ES2 ME1/ME2. NA1. [CB]
    Complementation_data: [Hodgkin JA] complements aex-5(sa23), unc-100(su149)
    Strain (13)
    RNASeq_FPKM (74)
    GO_annotation: 00020596
      00020597
      00020598
      00020599
      00020600
      00020601
      00020602
      00020603
      00020604
      00020605
    Ortholog (56)
    Paralog: WBGene00000583 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00008543 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: unc-122 encodes a type II transmembrane protein with extracellular collagen-like repeats and a highly conserved olfactomedin (OLF) domain that is found in a family of secreted proteins involved in formation and function of nervous systems; UNC-122 negatively regulates cholinergic neuromuscular synaptic transmission, and is required for normal locomotion and morphology of the DVB motorneuron; mosaic analysis indicates that UNC-122 acts in muscle cells to regulate synaptic transmission and locomotory behavior; UNC-122 expression is observed in body wall muscle cells and the coelomocytes; in body wall muscles, UNC-122 localizes to the postsynaptic neuromuscular junction. Paper_evidence: WBPaper00002665
            WBPaper00012807
            WBPaper00006427
          Curator_confirmed: WBPerson1843
          Date_last_updated: 13 Jul 2015 00:00:00
      Automated_description: Involved in negative regulation of cholinergic synaptic transmission. Located in postsynaptic membrane. Expressed in body wall musculature and coelomocyte. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Is an ortholog of human GLDN (gliomedin) and OLFML2B (olfactomedin like 2B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060558 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:29514)
  Molecular_info: Corresponding_CDS: F11C3.2
    Corresponding_CDS_history: F11C3.2:wp252
    Corresponding_transcript: F11C3.2.1
    Other_sequence (15)
    Associated_feature: WBsf643864
  Experimental_info: RNAi_result (6)
    Expr_pattern: Chronogram626
      Chronogram1379
      Expr2859
      Expr2860
      Expr5736
      Expr1029064
      Expr1032902
      Expr1148310
      Expr2017844
      Expr2035980
    Drives_construct (68)
    Construct_product: WBCnstr00010990
      WBCnstr00034124
    Microarray_results (19)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_CoreEnriched
      WBPaper00037950:coelomocytes_embryo_enriched
      WBPaper00037950:coelomocytes_embryo_SelectivelyEnriched
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:coelomocytes_larva_enriched
      WBPaper00037950:coelomocytes_larva_SelectivelyEnriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00044736:flat_dev_expression
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:daf-2(e1370)_daf-16(mu86)_upregulated_neuron
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056290:mdt-15(mg584)_upregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058678:DAF-12_upregulated_PVD
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060909:atfs-1(et18)_downregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061340:Coelomocyte
      WBPaper00061527:xbx-3-DH11.5_20397
      WBPaper00061651:Coelomocyte_enriched
      WBPaper00061853:tunicamycin_upregulated_N2
      WBPaper00062095:unc-4(e120)_upregulated_VA-neuron
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:12_0
      WBPaper00065993:glp-1(e2141)_upregulated
      cgc4489_group_9
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036286:Pattern_C
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(143_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(143_min)
    Interaction: WBInteraction000002346
      WBInteraction000002347
      WBInteraction000002348
      WBInteraction000031893
      WBInteraction000031895
      WBInteraction000031896
      WBInteraction000166446
      WBInteraction000166447
      WBInteraction000166448
      WBInteraction000364445
    Anatomy_function: WBbtf0275
      WBbtf0276
      WBbtf0277
      WBbtf0278
      WBbtf1052
      WBbtf1053
  Map_info: Map: I Position: 27.9705 Error: 0.034616
    Well_ordered
    Positive: Positive_clone: F11C3 Person_evidence: WBPerson385
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 6015
      Multi_point: 4455
      Pos_neg_data: 5950
        5951
        5952
        5953
        5954
  Reference (20)
  Remark: [Hodgkin JA] extracted from complex strain CB3337, isolated by Hedgecock EM
    Sequence connection from [Loria P, Hobert O]
  Method: Gene