WormBase Tree Display for Variation: WBVar00145247

WBVar00145247 Name: Public_name: ev554
  Sequence_details: Mapping_target: C53D6
    Type_of_mutation: Substitution
    SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00029121
    Laboratory: NW
    Status: Live
  Affects: Gene: WBGene00006852
    Interactor: WBInteraction000518995
      WBInteraction000519840
      WBInteraction000538537
      WBInteraction000538547
      WBInteraction000538548
      WBInteraction000538549
      WBInteraction000538552
      WBInteraction000538554
  Genetics: Map: IV Position: 4.1
    Mapping_data: In_multi_point: 3431
        3432
        3433
        4057
        4058
  Description: Phenotype: WBPhenotype:0000002 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: variable kinker Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000181 Paper_evidence: WBPaper00031671
        Curator_confirmed: WBPerson2021
        Remark: The dorsal and subventral processes of the NSM neurons showed a variety of initiation and termination defects that affected 43% of NSM neurons Paper_evidence: WBPaper00031671
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00031671
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0003666 PATO:0000460 Paper_evidence: WBPaper00031671
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: zdIs13 [ tph-1p::GFP] Paper_evidence: WBPaper00031671
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000195 Paper_evidence: WBPaper00005809
        Curator_confirmed: WBPerson2987
        Remark: "In their respective double mutants with the hypomorph unc-5(e152), both unc-129 and dbl-1 mutations, but not other mutants tested, caused significant increases in the frequency of DTC migration defects compared with unc-5(e152) alone (Table 3)... The double mutant unc-5(e152) unc-129(ev554) was significantly different from unc-5(e152) in the frequency of anterior (P < 0.005) but not posterior (P > 0.08) DTC defects." Paper_evidence: WBPaper00005809
            Curator_confirmed: WBPerson2987
          "The double mutant unc-5(e53) unc-129(ev554) exhibited a small but significant (P < 0.02) reduction in the frequency of anterior DTC migration defects (Table 3)." Paper_evidence: WBPaper00005809
            Curator_confirmed: WBPerson2987
        Penetrance: Incomplete: Paper_evidence: WBPaper00005809
              Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0006865 PATO:0000460 Paper_evidence: WBPaper00005809
                Curator_confirmed: WBPerson2987
          GO_term: GO:0016477 PATO:0000460 Paper_evidence: WBPaper00005809
                Curator_confirmed: WBPerson2987
        Phenotype_assay: Genotype: unc-5(e152) Paper_evidence: WBPaper00005809
              Curator_confirmed: WBPerson2987
            unc-5(e53) Paper_evidence: WBPaper00005809
              Curator_confirmed: WBPerson2987
      WBPhenotype:0000384 Paper_evidence: WBPaper00032163
          WBPaper00040335
        Curator_confirmed: WBPerson712
          WBPerson7190
        Remark: Half of animals exhibited DA9 axon guidance defects. Paper_evidence: WBPaper00032163
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005303 PATO:0000460 Paper_evidence: WBPaper00032163
                Curator_confirmed: WBPerson712
            WBbt:0005270 PATO:0000460 Paper_evidence: WBPaper00032163
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: 25 Paper_evidence: WBPaper00032163
              Curator_confirmed: WBPerson712
          Genotype: unc-5::intron::unc-5 Paper_evidence: WBPaper00032163
              Curator_confirmed: WBPerson712
      WBPhenotype:0000643 Paper_evidence: WBPaper00040335
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
          WBPerson7190
        Remark: uncoordinated Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001224 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: axons grow in aberrant directions Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000845 Paper_evidence: WBPaper00034730
        Curator_confirmed: WBPerson2021
        Remark: Mutants had normal sensitivity to cholinergic agonists Paper_evidence: WBPaper00034730
            Curator_confirmed: WBPerson2021
        Affected_by: Molecule: WBMol:00004019 Paper_evidence: WBPaper00034730
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000847 Paper_evidence: WBPaper00032163
        Curator_confirmed: WBPerson712
        Remark: RAB-3::GFP was not observed to be mislocalized to dendrites. Paper_evidence: WBPaper00032163
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0004857 PATO:0000460 Paper_evidence: WBPaper00032163
                Curator_confirmed: WBPerson712
      WBPhenotype:0001573 Paper_evidence: WBPaper00034730
        Curator_confirmed: WBPerson2021
        Remark: Mutants had normal sensitivity to cholinergic agonists Paper_evidence: WBPaper00034730
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001652 Paper_evidence: WBPaper00032446
        Curator_confirmed: WBPerson2021
  Reference: WBPaper00040335
    WBPaper00031671
    WBPaper00034730
    WBPaper00032446
    WBPaper00025979
    WBPaper00005809
    WBPaper00018953
    WBPaper00032163
  Remark: Molecular change reported to be D327 to Stop. Paper_evidence: WBPaper00003139
  Method: Substitution_allele