WormBase Tree Display for Gene: WBGene00003231

WBGene00003231 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: AH6
  Identity: Version: 1
    Name: CGC_name: mex-6 Person_evidence: WBPerson498
      Sequence_name: AH6.5
      Molecular_name: AH6.5
        AH6.5.1
        CE26846
      Other_name: CELE_AH6.5 Accession_evidence: NDB BX284602
      Public_name: mex-6
    DB_info: Database: AceView gene 2J815
        WormQTL gene WBGene00003231
        WormFlux gene WBGene00003231
        NDB locus_tag CELE_AH6.5
        Panther gene CAEEL|WormBase=WBGene00003231|UniProtKB=Q09436
          family PTHR12547
        NCBI gene 174504
        RefSeq protein NM_063642.7
        SwissProt UniProtAcc Q09436
        TREEFAM TREEFAM_ID TF322043
        UniProt_GCRP UniProtAcc Q09436
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mex
    Allele (40)
    Legacy_information: [Priess, J./Plasterk,] pk440: Strain is viable, but enhances phenotype of maternal-effect lethal mutation mex-5(zu199). Embryos from mex-6(pk440);mex-5(zu199) hermaphrodites produce only hypodermis and muscle cell types.
    Strain: WBStrain00022453
      WBStrain00022485
      WBStrain00022487
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (29)
    Paralog: WBGene00003228 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003230 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00011376 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004027 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003864 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003865 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003388 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009532 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013370 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009537 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007961 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013319 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013797 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013796 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013794 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009539 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004078 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017182 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022438 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022446 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: mex-6 encodes a CCCH zinc-finger protein highly similar to MEX-5 that functions with MEX-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish PIE-1, MEX-1, and POS-1 asymmetry in embryos, and also affects formation of intestinal cells; MEX-6 and MEX-5 may act downstream of the PAR proteins. Paper_evidence: WBPaper00004540
            WBPaper00005160
            WBPaper00005654
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables mRNA 3'-UTR binding activity; protein domain specific binding activity; and protein kinase binding activity. Involved in regulation of protein localization. Located in P granule. Expressed in AB; ABa; ABp; and germ line. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: AH6.5
    Corresponding_CDS_history: AH6.5:wp12
      AH6.5:wp43
    Corresponding_transcript: AH6.5.1
    Other_sequence: CGC00109_1
    Associated_feature: WBsf028078
      WBsf976539
      WBsf976540
      WBsf976541
      WBsf976542
      WBsf978799
      WBsf989072
      WBsf221892
      WBsf221893
    Transcription_factor: WBTranscriptionFactor000454
  Experimental_info: RNAi_result (68)
    Expr_pattern: Expr2463
      Expr4100
      Expr10817
      Expr1016913
      Expr1031528
      Expr1142831
      Expr2013544
      Expr2031778
    Drives_construct: WBCnstr00036173
      WBCnstr00039800
    Construct_product: WBCnstr00000077
      WBCnstr00005217
      WBCnstr00036173
      WBCnstr00039800
    Antibody: WBAntibody00000903
    Microarray_results (21)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00037950:BAG-neuron_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_embryo_enriched
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00041222:unc-120(st364)_downregulated
      WBPaper00041954:ethanol_upregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:rising_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045217:prg-1_progressively_regulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045420:fertilization_upregulated_protein
      WBPaper00045521:Oogenic
      WBPaper00045618:fbf-1_downregulated
      WBPaper00045618:puf-8_downregulated
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048762:FOG-3_associated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00049954:BPA_downregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051461:pig-1(gm344)_upregulated
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053154:human-amyloid-beta_tau_regulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_embryo_SMARTseq
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00054191:H3.3(null)_L1_upregulated
      WBPaper00054493:hpl-2(tm1489)_downregulated
      WBPaper00054792:FOG-3_interacting
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Metformin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056161:hermaphrodite_enriched_siRNA
      WBPaper00056284:ints-5(RNAi)_downregulated
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057154:HeatShock_upregulated_miRNA-target
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:cfp-1(tm6369)_upregulated
      WBPaper00058886:anp-1(ok608)_downregulated
      WBPaper00059174:MEG-3_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00059728:5ug_cholesterol_downregulated
      WBPaper00059728:20ug_cholesterol_downregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_L4
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:HB101_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061045:Y56A3A.22(cck200)_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061340:AIZ
      WBPaper00061340:Germline
      WBPaper00061340:XXX
      WBPaper00061527:puf-3-oma-2_18268
      WBPaper00061527:T22D1.5-inx-14
      WBPaper00062118:neural-HSF-1_upregulated
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062440:crh-1(n3315)_upregulated
      WBPaper00062446:nhr-8(hd117)_downregulated
      WBPaper00062587:lsl-1(ljm1)_downregulated
      WBPaper00062587:lsl-1(tm4769)_downregulated
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064502:spe-44(fx110)_upregulated
      WBPaper00064505:tamoxifen_upregulated
      WBPaper00064532:pals-25(icb98)_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00064871:hypoxia_upregulated_F2
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_20C
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065288:mdt-15(tm2182)_upregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065926:pgph-2(overepxreesion)_upregulated
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:Doxorubicin_downregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_4_2
      cgc4489_group_9
      WBPaper00025032:cluster_1
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00027758:Group_I
      WBPaper00032165:differentially_expressed_with_age_medoid_3
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_F
      WBPaper00037147:heatshock_upregulated
      WBPaper00037611:RNP-8-associated
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040963:TA300_down
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00046083:pmk-1(km25)_OP50_upregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00051387:Triclosan_downregulated
      WBPaper00053236:daf-16(mgDF50)_regulated_Starved
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00056330:mrps-5(RNAi)_downregulated
      [cgc5767]:cluster_1
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(41_min)
      [cgc5767]:expression_class_MD_pd(53_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
      [cgc6390]:Cluster_E
      [cgc6390]:oogenesis-enriched
    Interaction (365)
    WBProcess: WBbiopr:00000017
  Map_info: Map: II Position: 1.49849 Error: 0.002846
    Positive: Positive_clone: AH6 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4488
    Pseudo_map_position
  Reference (58)
  Remark: Sequence analysis of the mex-6(pk440) allele showed that bases 12737- 15477 corresponding to the AH6 cosmid were deleted. This work was done in the lab of Ron Plasterk.
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene