[Priess, J./Plasterk,] pk440: Strain is viable, but enhances phenotype of maternal-effect lethal mutation mex-5(zu199). Embryos from mex-6(pk440);mex-5(zu199) hermaphrodites produce only hypodermis and muscle cell types.
mex-6 encodes a CCCH zinc-finger protein highly similar to MEX-5 that functions with MEX-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish PIE-1, MEX-1, and POS-1 asymmetry in embryos, and also affects formation of intestinal cells; MEX-6 and MEX-5 may act downstream of the PAR proteins.
Enables mRNA 3'-UTR binding activity; protein domain specific binding activity; and protein kinase binding activity. Involved in regulation of protein localization. Located in P granule. Expressed in AB; ABa; ABp; and germ line.
Sequence analysis of the mex-6(pk440) allele showed that bases 12737- 15477 corresponding to the AH6 cosmid were deleted. This work was done in the lab of Ron Plasterk.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.