WormBase Tree Display for Gene: WBGene00005153
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| WBGene00005153 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | srf-3 | Person_evidence | WBPerson494 | |||||
| Sequence_name | M02B1.1 | ||||||||
| Molecular_name | M02B1.1a | ||||||||
| M02B1.1a.1 | |||||||||
| CE43555 | |||||||||
| M02B1.1b | |||||||||
| CE37656 | |||||||||
| M02B1.1c | |||||||||
| CE45668 | |||||||||
| M02B1.1b.1 | |||||||||
| M02B1.1c.1 | |||||||||
| Other_name | CELE_M02B1.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | srf-3 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 28 Jul 2004 10:05:41 | WBPerson1971 | Event | Acquires_merge | WBGene00010826 | ||||
| Acquires_merge | WBGene00010826 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | srf | ||||||||
| Reference_allele | WBVar00275411 | ||||||||
| Allele (175) | |||||||||
| Legacy_information | [C.elegansII] yj10 : increased binding of anti-cuticle antiserum, ectopic WGA lectin binding, no labelling with L1-specific mAb M38. Gross morphology WT. Fragile cuticle, increased drug permeability, reduced SDS resistance of dauers. OA1: ct107[Hemmer et al. 1991; Link et al. 1992; AT; CL] | ||||||||
| Strain | WBStrain00000252 | ||||||||
| WBStrain00004702 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Contained_in_operon | CEOP4666 | ||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00015404 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00014139 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00019451 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00015038 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00022577 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00018414 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00022721 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | srf-3 encodes a nucleotide sugar transporter (NST) most similar to the subfamily of UDP-galactose and UDP-N-acetylgalactosamine transporters; SRF-3 can function as a nucleotide sugar transporter in heterologous in vitro and in vivo systems using UDP-galactose and UDP-N-acetylglucosamine as substrates; mutations in srf-3 alter the surface antigenicity of the cuticle in C. elegans; srf-3 mutations show altered binding to antibodies raised against the cuticles of wild-type worms, and lectins like wheat germ agglutinin; srf-3 mutants are resistant to infection by the nematode-specific pathogen, Microbacterium nematophilum, and to the adherence of bacteria like Yersinia pseudotuberculosis which form biofilms; this resistance is most likely due to an altered glycoconjugate surface composition; srf-3 mutants also show an altered response in the form of increased susceptibility to nematophagous fungi; srf-3 mutants seem to have fragile cuticles compared to wild-type; srf-3 is expressed in seam cells, glandular cells g1/g2 and the spermatheca. | Paper_evidence | WBPaper00001576 | |||||
| WBPaper00001002 | |||||||||
| WBPaper00001706 | |||||||||
| WBPaper00001280 | |||||||||
| WBPaper00004539 | |||||||||
| WBPaper00003623 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 10 Oct 2011 00:00:00 | ||||||||
| Automated_description | Enables UDP-N-acetylglucosamine transmembrane transporter activity and UDP-galactose transmembrane transporter activity. Involved in UDP-N-acetylglucosamine transmembrane transport and UDP-galactose transmembrane transport. Located in Golgi membrane and perinuclear region of cytoplasm. Expressed in pharyngeal gland cell; seam cell; spermatheca; and vas deferens. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIm. Is an ortholog of human SLC35A2 (solute carrier family 35 member A2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:104 | Homo sapiens | Paper_evidence | WBPaper00006215 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 07 Nov 2023 00:00:00 | ||||||||
| Potential_model | DOID:0070265 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11022) | |||||
| Disease_relevance | C. elegans is used as a model system to study bacterial adherence via biofilm formation and to identify genes in the infectious agent as well as the host that are required for infection; elegans srf genes are required for cuticle surface properties like binding to antigens, and for the adherence of bacterial pathogens like Yersinia pseduotuberculosis and Yersinia pestis via biofilms. | Homo sapiens | Paper_evidence | WBPaper00001706 | |||||
| WBPaper00026735 | |||||||||
| WBPaper00029153 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Mar 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000015 | ||||||||
| Molecular_info | Corresponding_CDS | M02B1.1a | |||||||
| M02B1.1b | |||||||||
| M02B1.1c | |||||||||
| Corresponding_CDS_history | M02B1.1:wp109 | ||||||||
| M02B1.1:wp133 | |||||||||
| M02B1.1:wp201 | |||||||||
| Corresponding_transcript | M02B1.1a.1 | ||||||||
| M02B1.1b.1 | |||||||||
| M02B1.1c.1 | |||||||||
| Other_sequence | CRC11400_1 | ||||||||
| FC815126.1 | |||||||||
| PPC11536_1 | |||||||||
| JI467852.1 | |||||||||
| CR05429 | |||||||||
| SRC00576_1 | |||||||||
| JO472062.1 | |||||||||
| SR01573 | |||||||||
| Name_isotig07744 | |||||||||
| JI171965.1 | |||||||||
| Associated_feature | WBsf646492 | ||||||||
| WBsf659850 | |||||||||
| WBsf998259 | |||||||||
| WBsf1018447 | |||||||||
| WBsf229337 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00050803 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00062589 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3026 | ||||||||
| Expr1013846 | |||||||||
| Expr1032513 | |||||||||
| Expr1154495 | |||||||||
| Expr2016312 | |||||||||
| Expr2034539 | |||||||||
| Drives_construct | WBCnstr00011081 | ||||||||
| Construct_product | WBCnstr00011081 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (86) | |||||||||
| Interaction | WBInteraction000008513 | ||||||||
| WBInteraction000008514 | |||||||||
| WBInteraction000008515 | |||||||||
| WBInteraction000008516 | |||||||||
| WBInteraction000052148 | |||||||||
| WBInteraction000052751 | |||||||||
| WBInteraction000326994 | |||||||||
| WBInteraction000425692 | |||||||||
| WBProcess | WBbiopr:00000008 | ||||||||
| WBbiopr:00000039 | |||||||||
| Map_info (3) | |||||||||
| Reference (50) | |||||||||
| Method | Gene |
