WormBase Tree Display for Gene: WBGene00001077
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| WBGene00001077 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | dpy-18 | Person_evidence | WBPerson261 | |||||
| Sequence_name | Y47D3B.10 | ||||||||
| Molecular_name | Y47D3B.10 | ||||||||
| Y47D3B.10.1 | |||||||||
| CE20261 | |||||||||
| Other_name | phy-1 | ||||||||
| T28D6.1 | Paper_evidence | WBPaper00005747 | |||||||
| CELE_Y47D3B.10 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | dpy-18 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dpy | ||||||||
| Reference_allele | WBVar00143150 | ||||||||
| Allele | WBVar00143134 | Inferred_automatically | From strain object: BC3033 | ||||||
| WBVar00143254 | Inferred_automatically | From strain object: CB7248 | |||||||
| From strain object: GE1825 | |||||||||
| From strain object: GE337 | |||||||||
| From strain object: GE341 | |||||||||
| From strain object: GE346 | |||||||||
| From strain object: MT20113 | |||||||||
| From strain object: NJ523 | |||||||||
| From strain object: NJ524 | |||||||||
| WBVar00091485 | Inferred_automatically | From strain object: JK2729 | |||||||
| WBVar00241825 | |||||||||
| WBVar00000568 | |||||||||
| WBVar00241999 | |||||||||
| WBVar00241998 | |||||||||
| WBVar00144368 | |||||||||
| WBVar00862265 | |||||||||
| WBVar01771192 | |||||||||
| WBVar00602495 | |||||||||
| WBVar01646314 | |||||||||
| WBVar01646315 | |||||||||
| WBVar01646316 | |||||||||
| WBVar01646317 | |||||||||
| WBVar01646318 | |||||||||
| WBVar00143738 | |||||||||
| WBVar00146627 | |||||||||
| WBVar01269731 | |||||||||
| WBVar01269733 | |||||||||
| WBVar01269734 | |||||||||
| WBVar01269735 | |||||||||
| WBVar01269737 | |||||||||
| WBVar01499774 | |||||||||
| WBVar01702109 | |||||||||
| WBVar01702110 | |||||||||
| WBVar00143877 | |||||||||
| WBVar01448753 | |||||||||
| WBVar01579054 | |||||||||
| WBVar01579055 | |||||||||
| WBVar01579056 | |||||||||
| WBVar01334816 | |||||||||
| WBVar00143904 | |||||||||
| WBVar01723787 | |||||||||
| WBVar01723788 | |||||||||
| WBVar01507743 | |||||||||
| WBVar01409625 | |||||||||
| WBVar01409626 | |||||||||
| WBVar01499987 | |||||||||
| WBVar00409262 | |||||||||
| WBVar00409263 | |||||||||
| WBVar00409264 | |||||||||
| WBVar01995858 | |||||||||
| WBVar00409265 | |||||||||
| WBVar00409266 | |||||||||
| WBVar00409267 | |||||||||
| WBVar00409268 | |||||||||
| WBVar00409269 | |||||||||
| WBVar00409270 | |||||||||
| WBVar00409271 | |||||||||
| WBVar00409272 | |||||||||
| WBVar00409273 | |||||||||
| WBVar00409274 | |||||||||
| WBVar00409275 | |||||||||
| WBVar00565850 | |||||||||
| WBVar00409276 | |||||||||
| WBVar00565851 | |||||||||
| WBVar00409277 | |||||||||
| WBVar00565852 | |||||||||
| WBVar00565853 | |||||||||
| WBVar00143141 | |||||||||
| WBVar00270046 | |||||||||
| WBVar00143150 | |||||||||
| WBVar02081717 | |||||||||
| WBVar02019271 | |||||||||
| WBVar01963314 | |||||||||
| WBVar00862232 | |||||||||
| WBVar00179791 | |||||||||
| WBVar00862233 | |||||||||
| WBVar00862234 | |||||||||
| WBVar00862235 | |||||||||
| WBVar00862236 | |||||||||
| WBVar00862237 | |||||||||
| WBVar00862238 | |||||||||
| WBVar00862239 | |||||||||
| WBVar00862240 | |||||||||
| WBVar00862241 | |||||||||
| WBVar00862242 | |||||||||
| WBVar00862243 | |||||||||
| WBVar00862244 | |||||||||
| WBVar00862245 | |||||||||
| WBVar00862246 | |||||||||
| WBVar00862247 | |||||||||
| WBVar00862248 | |||||||||
| WBVar00862249 | |||||||||
| WBVar00862250 | |||||||||
| WBVar00862251 | |||||||||
| WBVar00862252 | |||||||||
| WBVar00242000 | |||||||||
| WBVar00862253 | |||||||||
| WBVar00862254 | |||||||||
| WBVar00862255 | |||||||||
| WBVar00862256 | |||||||||
| WBVar00862257 | |||||||||
| WBVar00862258 | |||||||||
| WBVar00862259 | |||||||||
| WBVar00862260 | |||||||||
| WBVar00862261 | |||||||||
| WBVar00862262 | |||||||||
| WBVar00862263 | |||||||||
| WBVar00862264 | |||||||||
| Possibly_affected_by | WBVar02158838 | ||||||||
| Legacy_information | e364amber : medium dumpy. ES3 (adult) ES2 (larvae). ME2. NA3 (e499 e1270). | ||||||||
| See also e1862 | |||||||||
| [C.elegansII] e364amb : medium dumpy. ES3 (adult) ES2 (larvae). ME2. Males have abnormal lumpy rays (Ram) at 25C. OA>10: e499, e1270, e1862,s361fdi, s1304 (induced on eT1), bx26 (Ram at 25C), h662. [Brenner 1974; Baird and Emmons 1990; PB] | |||||||||
| Strain (219) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (60) | |||||||||
| Paralog | WBGene00015773 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| WBGene00004026 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| WormBase-Compara | |||||||||
| WBGene00012815 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| WormBase-Compara | |||||||||
| WBGene00004025 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00077688 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | dpy-18 encodes a catalytic alpha subunit of collagen prolyl 4-hydroxylase (P4H) orthologous to human P4H alpha (I) isoform (OMIM: 176710), an alpha subunit of prolyl-4-hydroxylase which is a procollagen modifying enzyme required for exoskeleton formation, morphogenesis and maintenance of body shape; dpy-18 has a critical role in hydroxylation of cuticle collagens during collagen synthesis; dpy-18, in complex with phy-2, is essential for the survival of the C. elegans; dpy-18 mutations alone result in a mild dumpy phenotype; expressed dpy-18 and ten-1 act in parallel influencing the connection between epidermis and muscle during embryonic development; deletion of dpy-18 causes aggregation of collagen IV in body wall muscles in elongated embryos and triggers the loss of tissue integrity in ten-1 mutants; dpy-18 is expressed throughout the hypodermis, head and posterior neurons. | Paper_evidence | WBPaper00004203 | |||||
| WBPaper00031524 | |||||||||
| WBPaper00039988 | |||||||||
| Curator_confirmed | WBPerson12884 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 18 Aug 2011 00:00:00 | ||||||||
| Automated_description | Enables procollagen-proline 4-dioxygenase activity. Involved in several processes, including cuticle development involved in collagen and cuticulin-based cuticle molting cycle; embryo development; and embryonic body morphogenesis. Located in endoplasmic reticulum. Expressed in hypodermis; muscle cell; neurons; and pharynx. Human ortholog(s) of this gene implicated in myopia. Is an ortholog of human P4HA1 (prolyl 4-hydroxylase subunit alpha 1) and P4HA2 (prolyl 4-hydroxylase subunit alpha 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:11830 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8547) | ||||
| Molecular_info | Corresponding_CDS | Y47D3B.10 | |||||||
| Corresponding_transcript | Y47D3B.10.1 | ||||||||
| Other_sequence (83) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00056767 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00115627 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027622 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00026722 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00094817 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065822 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00094816 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00009344 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00019394 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1085 | ||||||||
| Expr1928 | |||||||||
| Expr1931 | |||||||||
| Expr12145 | |||||||||
| Expr1012505 | |||||||||
| Expr1030685 | |||||||||
| Expr1160222 | |||||||||
| Expr1200375 | |||||||||
| Expr2011060 | |||||||||
| Expr2029297 | |||||||||
| Drives_construct | WBCnstr00008961 | ||||||||
| WBCnstr00010073 | |||||||||
| WBCnstr00010524 | |||||||||
| WBCnstr00020362 | |||||||||
| WBCnstr00037095 | |||||||||
| Construct_product | WBCnstr00008961 | ||||||||
| WBCnstr00008962 | |||||||||
| WBCnstr00008963 | |||||||||
| WBCnstr00010073 | |||||||||
| WBCnstr00037095 | |||||||||
| Antibody | WBAntibody00000539 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (232) | |||||||||
| Interaction (111) | |||||||||
| WBProcess | WBbiopr:00000124 | ||||||||
| Map_info | Map | III | Position | 8.85117 | Error | 0.054776 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | tDp1 | |||||||
| mT1 | |||||||||
| Positive_clone | Y47D3B | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point (58) | ||||||||
| Multi_point (145) | |||||||||
| Pos_neg_data (11) | |||||||||
| Landmark_gene | |||||||||
| Reference (127) | |||||||||
| Method | Gene |
