rh18mat : XX phenotype is zygotic weak dumpy maternal effect dumpy/near lethal like dpy-26 but non-Him. ES2. XO phenotype nearly wildtype male (ME3). NA1.
[C.elegansII] rh18mat : XX phenotype is zygotic weak dumpy maternal effect dumpy/near lethal like Dpy-26 but non-Him. ES2. XO phenotype nearly wildtype male (ME3). OA5: y57 (weaker allele), y44, y42, y56am, y49 (strongest allele). Cloned: encodes 1469 aa protein with similarities to chromosome structural proteins, specifically localized to X chromosomes in XX but not XO animals. [Plenefisch et al. 1989; Chuang et al. 1994]
dpy-27 encodes an ATP-binding protein that is a homolog of the SMC4 subunit of mitotic condensin; DPY-27, in combination with other proteins including MIX-1, act as a unit to repress X-linked gene expression during hermaphrodite dosage compensation; in XX oocytes and early embryos, DPY-27 exhibits diffuse nuclear localization, but by the 30-cell stage of embryogenesis, DPY-27 specifically localizes to X chromosomes; in XO animals at all stages, DPY-27 remains diffusely nuclear; the sex-specific localization of DPY-27 to X chromosomes is dependent upon wild-type activity of xol-1, as DPY-27 mislocalizes to the X chromosome of XO embryos in a xol-1 mutant background.
Enables sequence-specific DNA binding activity. Involved in dosage compensation by hypoactivation of X chromosome. Located in X chromosome and nuclear chromosome. Part of dosage compensation complex. Is an ortholog of human SMC4 (structural maintenance of chromosomes 4).