WormBase Tree Display for Gene: WBGene00002232

WBGene00002232 SMap: S_parent: Sequence: F11A6
  Identity: Version: 1
    Name: CGC_name: kpc-1 Person_evidence: WBPerson533
      Sequence_name: F11A6.1
      Molecular_name: F11A6.1a
        F11A6.1a.1
        CE17653
        F11A6.1a.2
        F11A6.1b
      Other_name: CELE_F11A6.1 Accession_evidence: NDB BX284601
      Public_name: kpc-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:27 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: kpc
    Allele (115)
    Strain: WBStrain00035504
    RNASeq_FPKM (74)
    GO_annotation (48)
    Ortholog (49)
    Paralog: WBGene00000088 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000254 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001172 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00017686 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: kpc-1 encodes two isoforms of a Kex2/subtilisin-like proprotein convertase that is a member of the subtilase family of calcium-dependent serine endoproteinases that includes mammalian furin (OMIM:136950) and Saccharomyces cerevisiae Kex2p; KPC-1 is required for normal growth and locomotion and is likely responsible for the processing of transforming growth factor (TGF) beta proproteins encoded by daf-7, dbl-1, and unc-129. Paper_evidence: WBPaper00004142
            WBPaper00018607
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables serine-type endopeptidase activity and signaling receptor binding activity. Involved in several processes, including neuron development; positive regulation of developmental process; and protein processing. Located in neuronal cell body. Expressed in several structures, including PVD; epithelial cell; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in arteriosclerosis; colon adenocarcinoma; and colorectal adenocarcinoma. Is an ortholog of human FURIN (furin, paired basic amino acid cleaving enzyme). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:234 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8747)
      DOID:2349 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8568)
      DOID:0050861 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8746)
  Molecular_info: Corresponding_CDS: F11A6.1a
    Corresponding_CDS_history: F11A6.1b:wp245
    Corresponding_transcript: F11A6.1b
      F11A6.1a.1
      F11A6.1a.2
    Other_sequence (36)
    Associated_feature (22)
  Experimental_info: RNAi_result: WBRNAi00116836 Inferred_automatically: RNAi_primary
      WBRNAi00003363 Inferred_automatically: RNAi_primary
      WBRNAi00089035 Inferred_automatically: RNAi_primary
      WBRNAi00106792 Inferred_automatically: RNAi_primary
      WBRNAi00044358 Inferred_automatically: RNAi_primary
      WBRNAi00027714 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00018109
      WBCnstr00018110
      WBCnstr00020063
    Construct_product: WBCnstr00018110
      WBCnstr00018228
      WBCnstr00019277
      WBCnstr00043014
    Microarray_results (39)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033070:Elbe_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00040412:germline-regulated_daf-16_target
      WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
      WBPaper00044037:eat-2_upregulated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044426:rotenone_5day_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Oogenic
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049018:swsn-2.2(RNAi)_downregulated
      WBPaper00049495:starvation-refeeding_regulated
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049594:osm-9(ok1677)_upregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:ash-2(RNAi)_regulated_intestine
      WBPaper00051257:Levamisole_upregulated
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055103:thoc-5(wy822)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055565:AVK_enriched
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059224:tph-1(mg280)_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059598:HeatShock_upregulated
      WBPaper00059605:MUT-16_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:AVB
      WBPaper00061340:AVE
      WBPaper00061340:AVL
      WBPaper00061340:DA
      WBPaper00061340:DB
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:g2_parent
      WBPaper00061340:mc1
      WBPaper00061340:Parent_of_MI_pm1DR
      WBPaper00061340:Pharyngeal_neuron
      WBPaper00061340:pm1_pm2
      WBPaper00061340:pm3_pm4_pm5
      WBPaper00061340:pm7
      WBPaper00061340:rect_D
      WBPaper00061340:RIC
      WBPaper00061340:RIC_parent
      WBPaper00061340:RME
      WBPaper00061340:RMED
      WBPaper00061340:RME_LR_parent
      WBPaper00061340:SIA
      WBPaper00061340:SIB
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:chd-7_16664-jmjd-3.1
      WBPaper00061527:nhr-46_2300-unc-108_2961
      WBPaper00061527:unc-13_19769-unc-13_278
      WBPaper00061651:FLP_enriched
      WBPaper00061651:I3_enriched
      WBPaper00061651:PVD_enriched
      WBPaper00061651:RID_enriched
      WBPaper00061651:RME_DV_enriched
      WBPaper00061651:VB_enriched
      WBPaper00061902:camt-1(ok515)_regulated_AFD
      WBPaper00062103:neuron_enriched
      WBPaper00062325:etr-1(lq61)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00064871:hypoxia_downregulated_F3
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065841:70_0
      WBPaper00065841:70_1
      WBPaper00065841:86_0
      WBPaper00065841:109_0
      WBPaper00065841:129_0
      WBPaper00066005:RAGA-1_degradation_somatic_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_5_4
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025032:cluster_5
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030839:Larval_A_Class
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035479:daf-16(RNAi)_downregulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:osm-11_regulated
      WBPaper00039851:Live_C_albicans_vs_HK_OP50
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00040985:AIN-2_L4_intestine
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042067:Cu2+_upregulated_WT
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00053827:pyoverdine_upregulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(101_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(101_min)
    Interaction (29)
  Map_info: Map: I Position: 9.53611 Error: 0.019245
    Positive: Positive_clone: F11A6 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4460
        4467
    Pseudo_map_position
  Reference (28)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene