WormBase Tree Display for Gene: WBGene00002232

WBGene00002232 SMap: S_parent: Sequence: F11A6
  Identity: Version: 1
    Name: CGC_name: kpc-1 Person_evidence: WBPerson533
      Sequence_name: F11A6.1
      Molecular_name: F11A6.1a
        F11A6.1a.1
        CE17653
        F11A6.1a.2
        F11A6.1b
      Other_name: CELE_F11A6.1 Accession_evidence: NDB BX284601
      Public_name: kpc-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:27 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: kpc
    Allele (115)
    Strain: WBStrain00035504
    RNASeq_FPKM (74)
    GO_annotation: 00030703
      00030704
      00030705
      00030706
      00030707
      00030708
      00030709
      00030710
      00030711
      00030712
      00030713
      00030714
      00030715
      00030716
      00030717
      00030718
      00030719
      00030720
      00030721
      00030722
      00030723
      00030724
      00030725
      00030726
      00030727
      00030728
      00030729
      00030730
      00030731
      00030732
      00030733
      00030734
      00030735
      00030736
      00030737
      00030738
      00030739
      00030740
      00030741
      00030742
      00030743
      00030744
      00030745
      00030746
      00030747
      00110242
      00110243
      00110244
    Ortholog (49)
    Paralog: WBGene00000088 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000254 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001172 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00017686 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: kpc-1 encodes two isoforms of a Kex2/subtilisin-like proprotein convertase that is a member of the subtilase family of calcium-dependent serine endoproteinases that includes mammalian furin (OMIM:136950) and Saccharomyces cerevisiae Kex2p; KPC-1 is required for normal growth and locomotion and is likely responsible for the processing of transforming growth factor (TGF) beta proproteins encoded by daf-7, dbl-1, and unc-129. Paper_evidence: WBPaper00004142
            WBPaper00018607
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables serine-type endopeptidase activity and signaling receptor binding activity. Involved in several processes, including neuron development; positive regulation of developmental process; and protein processing. Located in neuronal cell body. Expressed in several structures, including PVD; epithelial cell; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in arteriosclerosis; colon adenocarcinoma; and colorectal adenocarcinoma. Is an ortholog of human FURIN (furin, paired basic amino acid cleaving enzyme). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:234 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8747)
      DOID:2349 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8568)
      DOID:0050861 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8746)
  Molecular_info: Corresponding_CDS: F11A6.1a
    Corresponding_CDS_history: F11A6.1b:wp245
    Corresponding_transcript: F11A6.1b
      F11A6.1a.1
      F11A6.1a.2
    Other_sequence (36)
    Associated_feature (22)
  Experimental_info: RNAi_result: WBRNAi00116836 Inferred_automatically: RNAi_primary
      WBRNAi00003363 Inferred_automatically: RNAi_primary
      WBRNAi00089035 Inferred_automatically: RNAi_primary
      WBRNAi00106792 Inferred_automatically: RNAi_primary
      WBRNAi00044358 Inferred_automatically: RNAi_primary
      WBRNAi00027714 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00018109
      WBCnstr00018110
      WBCnstr00020063
    Construct_product: WBCnstr00018110
      WBCnstr00018228
      WBCnstr00019277
      WBCnstr00043014
    Microarray_results (39)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033070:Elbe_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00040412:germline-regulated_daf-16_target
      WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
      WBPaper00044037:eat-2_upregulated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044426:rotenone_5day_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Oogenic
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049018:swsn-2.2(RNAi)_downregulated
      WBPaper00049495:starvation-refeeding_regulated
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049594:osm-9(ok1677)_upregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:ash-2(RNAi)_regulated_intestine
      WBPaper00051257:Levamisole_upregulated
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055103:thoc-5(wy822)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055565:AVK_enriched
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059224:tph-1(mg280)_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059598:HeatShock_upregulated
      WBPaper00059605:MUT-16_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:AVB
      WBPaper00061340:AVE
      WBPaper00061340:AVL
      WBPaper00061340:DA
      WBPaper00061340:DB
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:g2_parent
      WBPaper00061340:mc1
      WBPaper00061340:Parent_of_MI_pm1DR
      WBPaper00061340:Pharyngeal_neuron
      WBPaper00061340:pm1_pm2
      WBPaper00061340:pm3_pm4_pm5
      WBPaper00061340:pm7
      WBPaper00061340:rect_D
      WBPaper00061340:RIC
      WBPaper00061340:RIC_parent
      WBPaper00061340:RME
      WBPaper00061340:RMED
      WBPaper00061340:RME_LR_parent
      WBPaper00061340:SIA
      WBPaper00061340:SIB
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:chd-7_16664-jmjd-3.1
      WBPaper00061527:nhr-46_2300-unc-108_2961
      WBPaper00061527:unc-13_19769-unc-13_278
      WBPaper00061651:FLP_enriched
      WBPaper00061651:I3_enriched
      WBPaper00061651:PVD_enriched
      WBPaper00061651:RID_enriched
      WBPaper00061651:RME_DV_enriched
      WBPaper00061651:VB_enriched
      WBPaper00061902:camt-1(ok515)_regulated_AFD
      WBPaper00062103:neuron_enriched
      WBPaper00062325:etr-1(lq61)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00064871:hypoxia_downregulated_F3
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065841:70_0
      WBPaper00065841:70_1
      WBPaper00065841:86_0
      WBPaper00065841:109_0
      WBPaper00065841:129_0
      WBPaper00066005:RAGA-1_degradation_somatic_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_5_4
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025032:cluster_5
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030839:Larval_A_Class
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035479:daf-16(RNAi)_downregulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:osm-11_regulated
      WBPaper00039851:Live_C_albicans_vs_HK_OP50
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00040985:AIN-2_L4_intestine
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042067:Cu2+_upregulated_WT
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00053827:pyoverdine_upregulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(101_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(101_min)
    Interaction (29)
  Map_info: Map: I Position: 9.53611 Error: 0.019245
    Positive: Positive_clone: F11A6 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4460
        4467
    Pseudo_map_position
  Reference (28)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene