WormBase Tree Display for Gene: WBGene00004719
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WBGene00004719 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | F15A2 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | sad-1 | Person_evidence | WBPerson42 | |||||
Sequence_name | F15A2.6 | ||||||||
Molecular_name | F15A2.6a | ||||||||
F15A2.6a.1 | |||||||||
CE28218 | |||||||||
F15A2.6b | |||||||||
CE40646 | |||||||||
F15A2.6b.1 | |||||||||
Other_name | CELE_F15A2.6 | Accession_evidence | NDB | BX284606 | |||||
Public_name | sad-1 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | sad | ||||||||
Allele (288) | |||||||||
Strain | WBStrain00002260 | ||||||||
WBStrain00001646 | |||||||||
WBStrain00005268 | |||||||||
WBStrain00023494 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (35) | |||||||||
Ortholog (44) | |||||||||
Paralog (19) | |||||||||
Structured_description | Concise_description | sad-1 encodes a novel serine/threonine protein kinase; SAD-1 activity is required for several aspects of presynaptic development, including termination of axon outgrowth and presynaptic vesicle clustering, in GABAergic motor neurons and the ASI amphid chemosensory neuron; in addition, SAD-1 functions in a complex with STRD-1, with which it physically interacts in vivo, to regulate axonal-dendritic polarity and synapse organization; SAD-1 is expressed in the nervous system, where it localizes asymmetrically to the synapse-rich regions of axons; SAD-1 localization to synapses depends upon STRD-1; SAD-1 exhibits kinase activity in vitro, phosphorylating recombinant human Tau. | Paper_evidence | WBPaper00004523 | |||||
WBPaper00035545 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 28 Jun 2010 00:00:00 | ||||||||
Automated_description | Enables protein kinase activity. Involved in cellular component organization; cellular localization; and establishment or maintenance of cell polarity. Located in axon and dendrite. Expressed in nervous system. Is an ortholog of human BRSK1 (BR serine/threonine kinase 1) and BRSK2 (BR serine/threonine kinase 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | F15A2.6a | |||||||
F15A2.6b | |||||||||
Corresponding_CDS_history | F15A2.6:wp53 | ||||||||
Corresponding_transcript | F15A2.6a.1 | ||||||||
F15A2.6b.1 | |||||||||
Other_sequence (26) | |||||||||
Associated_feature (13) | |||||||||
Experimental_info | RNAi_result (18) | ||||||||
Expr_pattern (18) | |||||||||
Drives_construct | WBCnstr00000850 | ||||||||
WBCnstr00002485 | |||||||||
WBCnstr00004357 | |||||||||
WBCnstr00005298 | |||||||||
WBCnstr00013124 | |||||||||
WBCnstr00013265 | |||||||||
WBCnstr00041292 | |||||||||
WBCnstr00041293 | |||||||||
Construct_product (18) | |||||||||
Antibody | WBAntibody00000343 | ||||||||
WBAntibody00001193 | |||||||||
Microarray_results (30) | |||||||||
Expression_cluster (173) | |||||||||
Interaction (33) | |||||||||
Map_info | Map | X | Position | 12.6561 | Error | 0.012226 | |||
Well_ordered | |||||||||
Positive | Positive_clone | F15A2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4019 | |||||||
4196 | |||||||||
4276 | |||||||||
Reference (54) | |||||||||
Remark | [email 93 from R. Lee and cgc4523] | ||||||||
Method | Gene |