WormBase Tree Display for Gene: WBGene00006755
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| WBGene00006755 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-16 | Person_evidence | WBPerson261 | |||||
| Sequence_name | ZK1098.10 | ||||||||
| Molecular_name (49) | |||||||||
| Other_name | egl-39 | ||||||||
| CELE_ZK1098.10 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | unc-16 | ||||||||
| DB_info | Database | AceView | gene | 3K645 | |||||
| WormQTL | gene | WBGene00006755 | |||||||
| WormFlux | gene | WBGene00006755 | |||||||
| NDB | locus_tag | CELE_ZK1098.10 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006755|UniProtKB=P34609 | |||||||
| family | PTHR13886 | ||||||||
| NCBI | gene | 176349 | |||||||
| RefSeq | protein (16) | ||||||||
| SwissProt | UniProtAcc | P34609 | |||||||
| TREEFAM | TREEFAM_ID | TF313096 | |||||||
| UniProt_GCRP | UniProtAcc | P34609 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00142966 | ||||||||
| Allele (140) | |||||||||
| Legacy_information | e109 : very sluggish small; males more active. ES3 ME2. NA1. | ||||||||
| See also e109 | |||||||||
| [Thomas JT ] Egl, Unc and defecation phenotypes, resembles Unc-16. | |||||||||
| n730ts : transient bloating at 25x Type C; uncoordinated sluggish weak coiler phenotype. ES3 (adult 25x) ES2 (other stages 25x). NA1. | |||||||||
| See also n730 | |||||||||
| [C.elegansII] e109 : very sluggish small; males more active. ES3 ME2. OA1: n730ts (pka egl-39, transient bloating at 25C; sensitive to serotonin and to imipramine; uncoordinated sluggish weak coiler phenotype. ES3 (adult 25C) ES2 (other stages 25C), ME2). [Brenner 1974; Trent et al. 1983; JT] | |||||||||
| Complementation_data | [Thomas JT ] n730 fails to complement unc-16(e109). | ||||||||
| Strain | WBStrain00023488 | ||||||||
| WBStrain00026866 | |||||||||
| WBStrain00004103 | |||||||||
| WBStrain00005379 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (34) | |||||||||
| Contained_in_operon | CEOP3830 | ||||||||
| Ortholog (47) | |||||||||
| Structured_description | Concise_description | unc-16 encodes a homolog of murine JIP3 (c-Jun N-terminal kinase (JNK)-interacting protein 3) and Drosophila SUNDAY DRIVER; unc-16 is involved in vesicle transport and mutations affect egg laying, locomotion, and defecation; UNC-16 physically interacts with JNK and JNK kinases, with the KLC-2 kinesin light chain, and the DLI-1 dynein light intermediate chain; UNC-16 is expressed in neurons of the ventral cord, retrovesicular and preanal ganglia, the nerve ring, intestinal cells, seam and hypodermal cells, body wall and head muscle, and pharynx. | Paper_evidence | WBPaper00000031 | |||||
| WBPaper00000635 | |||||||||
| WBPaper00001256 | |||||||||
| WBPaper00002315 | |||||||||
| WBPaper00005014 | |||||||||
| WBPaper00024617 | |||||||||
| WBPaper00038128 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 09 Mar 2011 00:00:00 | ||||||||
| Automated_description | Enables kinase binding activity; kinesin binding activity; and signaling adaptor activity. Involved in several processes, including defecation; egg-laying behavior; and regulation of JNK cascade. Located in axon; cell body; and cytoplasm. Expressed in body wall musculature; hypodermis; intestine; and nervous system. Human ortholog(s) of this gene implicated in endometrial cancer; hepatocellular carcinoma; and liver cirrhosis. Is an ortholog of human MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:5082 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14524) | ||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14524) | ||||||
| DOID:1380 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14524) | ||||||
| Molecular_info | Corresponding_CDS (16) | ||||||||
| Corresponding_CDS_history | ZK1098.10:wp84 | ||||||||
| Corresponding_transcript (17) | |||||||||
| Other_sequence (83) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result (19) | ||||||||
| Expr_pattern | Expr1778 | ||||||||
| Expr11021 | |||||||||
| Expr11973 | |||||||||
| Expr1013805 | |||||||||
| Expr1032829 | |||||||||
| Expr1162532 | |||||||||
| Expr2017851 | |||||||||
| Expr2035987 | |||||||||
| Drives_construct | WBCnstr00010435 | ||||||||
| Construct_product | WBCnstr00010435 | ||||||||
| WBCnstr00017645 | |||||||||
| Antibody | WBAntibody00002438 | ||||||||
| WBAntibody00003035 | |||||||||
| Microarray_results (60) | |||||||||
| Expression_cluster (122) | |||||||||
| SAGE_tag (23) | |||||||||
| Interaction (100) | |||||||||
| WBProcess | WBbiopr:00000010 | ||||||||
| Map_info | Map | III | Position | 0.58611 | Error | 0.010236 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | ZK1098 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | 2_point | 54 | |||||||
| 83 | |||||||||
| Multi_point (19) | |||||||||
| Pos_neg_data | 8639 | ||||||||
| Reference (68) | |||||||||
| Remark | n730 previously known as egl-39. unc-16 chosen as preferred name by Thomas JT, Horvitz HR. | ||||||||
| Sequence connection from [Jin Y] | |||||||||
| Method | Gene |
