WormBase Tree Display for Gene: WBGene00006769
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| WBGene00006769 | SMap | S_parent | Sequence | Y37E11C | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-33 | Person_evidence | WBPerson261 | |||||
| Sequence_name | Y37E11C.1 | ||||||||
| Molecular_name | Y37E11C.1a | ||||||||
| Y37E11C.1a.1 | |||||||||
| CE21557 | |||||||||
| Y37E11C.1b | |||||||||
| CE31638 | |||||||||
| Y37E11C.1c | |||||||||
| CE31639 | |||||||||
| Y37E11C.1b.1 | |||||||||
| Y37E11C.1c.1 | |||||||||
| Other_name | CELE_Y37E11C.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | unc-33 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00006769 | |||||
| WormFlux | gene | WBGene00006769 | |||||||
| NDB | locus_tag | CELE_Y37E11C.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006769|UniProtKB=Q01630 | |||||||
| family | PTHR11647 | ||||||||
| NCBI | gene | 177112 | |||||||
| RefSeq | protein | NM_001380147.1 | |||||||
| NM_001380148.1 | |||||||||
| NM_001038349.4 | |||||||||
| SwissProt | UniProtAcc | Q01630 | |||||||
| TrEMBL | UniProtAcc | U4PLJ8 | |||||||
| UniProt_GCRP | UniProtAcc | Q01630 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143034 | ||||||||
| Allele | WBVar00143818 | Inferred_automatically | From strain object: AMH23 | ||||||
| From strain object: AMH31 | |||||||||
| From strain object: AMH46 | |||||||||
| From strain object: AMH71 | |||||||||
| From strain object: CB1193 | |||||||||
| WBVar00089156 | Inferred_automatically | From strain object: AMH3 | |||||||
| From strain object: AMH32 | |||||||||
| From strain object: AMH36 | |||||||||
| From strain object: AMH57 | |||||||||
| From strain object: AMH69 | |||||||||
| From strain object: SP1382 | |||||||||
| WBVar00143870 | Inferred_automatically | From strain object: CB1261 | |||||||
| WBVar00143308 | Inferred_automatically | From strain object: CB572 | |||||||
| WBVar00088532 | Inferred_automatically | From strain object: DR7 | |||||||
| WBVar00089123 | Inferred_automatically | From strain object: SP998 | |||||||
| WBVar00241616 | |||||||||
| WBVar00241546 | |||||||||
| WBVar00143441 | |||||||||
| WBVar00143939 | |||||||||
| WBVar00603898 | |||||||||
| WBVar00603899 | |||||||||
| WBVar00899099 | |||||||||
| WBVar00899100 | |||||||||
| WBVar00899101 | |||||||||
| WBVar00899102 | |||||||||
| WBVar00899103 | |||||||||
| WBVar00899104 | |||||||||
| WBVar01514860 | |||||||||
| WBVar00899105 | |||||||||
| WBVar00899106 | |||||||||
| WBVar01514861 | |||||||||
| WBVar01514862 | |||||||||
| WBVar00899107 | |||||||||
| WBVar00899108 | |||||||||
| WBVar01514863 | |||||||||
| WBVar01451750 | |||||||||
| WBVar00899109 | |||||||||
| WBVar01514864 | |||||||||
| WBVar01451751 | |||||||||
| WBVar01668476 | |||||||||
| WBVar01514865 | |||||||||
| WBVar01451752 | |||||||||
| WBVar01668477 | |||||||||
| WBVar00899110 | |||||||||
| WBVar01668478 | |||||||||
| WBVar01514866 | |||||||||
| WBVar00899111 | |||||||||
| WBVar00899112 | |||||||||
| WBVar01514867 | |||||||||
| WBVar00899113 | |||||||||
| WBVar01514868 | |||||||||
| WBVar00899114 | |||||||||
| WBVar01514869 | |||||||||
| WBVar00899115 | |||||||||
| WBVar00899116 | |||||||||
| WBVar00899117 | |||||||||
| WBVar01630321 | |||||||||
| WBVar02053786 | |||||||||
| WBVar00899118 | |||||||||
| WBVar01630322 | |||||||||
| WBVar01630323 | |||||||||
| WBVar00600858 | |||||||||
| WBVar00899119 | |||||||||
| WBVar01630324 | |||||||||
| WBVar00899120 | |||||||||
| WBVar01630325 | |||||||||
| WBVar01922842 | |||||||||
| WBVar00899121 | |||||||||
| WBVar00899122 | |||||||||
| WBVar01630326 | |||||||||
| WBVar01922843 | |||||||||
| WBVar01630327 | |||||||||
| WBVar00899123 | |||||||||
| WBVar01922844 | |||||||||
| WBVar01630328 | |||||||||
| WBVar01922845 | |||||||||
| WBVar00899124 | |||||||||
| WBVar01922846 | |||||||||
| WBVar00899125 | |||||||||
| WBVar01630329 | |||||||||
| WBVar01922847 | |||||||||
| WBVar01630330 | |||||||||
| WBVar00899126 | |||||||||
| WBVar00899127 | |||||||||
| WBVar01922848 | |||||||||
| WBVar01630331 | |||||||||
| WBVar00899128 | |||||||||
| WBVar01630332 | |||||||||
| WBVar01922849 | |||||||||
| WBVar00899129 | |||||||||
| WBVar00899130 | |||||||||
| WBVar00899131 | |||||||||
| WBVar00899132 | |||||||||
| WBVar00899133 | |||||||||
| WBVar00899134 | |||||||||
| WBVar00899135 | |||||||||
| WBVar00899136 | |||||||||
| WBVar00899137 | |||||||||
| WBVar00899138 | |||||||||
| WBVar00899139 | |||||||||
| WBVar00899140 | |||||||||
| WBVar00899141 | |||||||||
| WBVar00899142 | |||||||||
| WBVar02096170 | |||||||||
| WBVar00899143 | |||||||||
| WBVar00899144 | |||||||||
| WBVar02146401 | |||||||||
| WBVar00899145 | |||||||||
| WBVar00899146 | |||||||||
| WBVar00899147 | |||||||||
| WBVar00899148 | |||||||||
| WBVar00899149 | |||||||||
| WBVar00899150 | |||||||||
| WBVar00899151 | |||||||||
| WBVar00899152 | |||||||||
| WBVar01990720 | |||||||||
| WBVar00899153 | |||||||||
| WBVar01990721 | |||||||||
| WBVar00899154 | |||||||||
| WBVar02103542 | |||||||||
| WBVar01990722 | |||||||||
| WBVar00899155 | |||||||||
| WBVar02103543 | |||||||||
| WBVar01990723 | |||||||||
| WBVar00899156 | |||||||||
| WBVar00899157 | |||||||||
| WBVar00899158 | |||||||||
| WBVar00899159 | |||||||||
| WBVar00899160 | |||||||||
| WBVar00899161 | |||||||||
| WBVar00899162 | |||||||||
| WBVar01896522 | |||||||||
| WBVar02113683 | |||||||||
| WBVar01898925 | |||||||||
| WBVar00253108 | |||||||||
| WBVar02133608 | |||||||||
| WBVar02133609 | |||||||||
| WBVar00143034 | |||||||||
| WBVar01580732 | |||||||||
| WBVar01580733 | |||||||||
| WBVar01965894 | |||||||||
| WBVar01965895 | |||||||||
| WBVar01965896 | |||||||||
| WBVar01965897 | |||||||||
| WBVar00187491 | |||||||||
| WBVar01965898 | |||||||||
| WBVar00187492 | |||||||||
| WBVar01965899 | |||||||||
| WBVar00187493 | |||||||||
| WBVar00187494 | |||||||||
| WBVar00187495 | |||||||||
| WBVar00187496 | |||||||||
| WBVar01846894 | |||||||||
| WBVar00187497 | |||||||||
| WBVar00187498 | |||||||||
| WBVar00187499 | |||||||||
| WBVar00187500 | |||||||||
| WBVar00187501 | |||||||||
| WBVar01499633 | |||||||||
| WBVar00187502 | |||||||||
| WBVar00187503 | |||||||||
| WBVar00187504 | |||||||||
| WBVar00187505 | |||||||||
| WBVar01838986 | |||||||||
| WBVar00187506 | |||||||||
| WBVar00187507 | |||||||||
| WBVar00421422 | |||||||||
| WBVar01838987 | |||||||||
| WBVar00421423 | |||||||||
| WBVar01838988 | |||||||||
| WBVar00187508 | |||||||||
| WBVar00421424 | |||||||||
| WBVar00187509 | |||||||||
| WBVar00421425 | |||||||||
| WBVar00187510 | |||||||||
| WBVar00421426 | |||||||||
| WBVar00421427 | |||||||||
| WBVar00421428 | |||||||||
| WBVar00421429 | |||||||||
| WBVar00421430 | |||||||||
| WBVar00421431 | |||||||||
| WBVar00421432 | |||||||||
| WBVar00421433 | |||||||||
| WBVar00421434 | |||||||||
| WBVar00421435 | |||||||||
| WBVar00421436 | |||||||||
| WBVar00421437 | |||||||||
| WBVar00421438 | |||||||||
| WBVar00421439 | |||||||||
| WBVar00246950 | |||||||||
| WBVar00421440 | |||||||||
| WBVar00421441 | |||||||||
| WBVar00421442 | |||||||||
| WBVar02020388 | |||||||||
| WBVar00421443 | |||||||||
| WBVar02020389 | |||||||||
| WBVar01481627 | |||||||||
| WBVar00421444 | |||||||||
| WBVar02020390 | |||||||||
| WBVar00421445 | |||||||||
| WBVar01481628 | |||||||||
| WBVar02020391 | |||||||||
| WBVar01481629 | |||||||||
| WBVar02020392 | |||||||||
| WBVar02020393 | |||||||||
| WBVar02020394 | |||||||||
| WBVar01497089 | |||||||||
| WBVar02075986 | |||||||||
| WBVar01913405 | |||||||||
| WBVar01913406 | |||||||||
| WBVar01727008 | |||||||||
| WBVar01727009 | |||||||||
| WBVar00571374 | |||||||||
| WBVar01727010 | |||||||||
| WBVar00571375 | |||||||||
| WBVar01727011 | |||||||||
| WBVar02036846 | |||||||||
| WBVar01727012 | |||||||||
| WBVar00571377 | |||||||||
| WBVar01727013 | |||||||||
| WBVar01727014 | |||||||||
| WBVar01727015 | |||||||||
| WBVar01727016 | |||||||||
| WBVar01727017 | |||||||||
| WBVar01727018 | |||||||||
| WBVar01727019 | |||||||||
| WBVar02070965 | |||||||||
| WBVar00261850 | |||||||||
| WBVar02070966 | |||||||||
| WBVar01727020 | |||||||||
| WBVar01727021 | |||||||||
| WBVar00270444 | |||||||||
| WBVar00270445 | |||||||||
| Possibly_affected_by | WBVar02156987 | ||||||||
| Legacy_information | e204 : very slow almost paralysed tends to curl dumpyish; weak FITC uptake; amphid phasmid PDE axons abnormal; abnormal neuronal microtubules. ES3 ME0. NA5 (e572 e735). | ||||||||
| See also e572, e1193, e1261, e1358 | |||||||||
| [C.elegansII] e204 : very slow, almost paralysed; tends to curl; dumpyish; weak FITC uptake; amphid, phasmid, PDE, PVP axons abnormal; multiple defects in axonogenesis; abnormally abundant neuronal microtubules. ES3 ME0. OA>10: e572, e735, e1358, m7,mn260::Tc4, rh1030::Tc4, etc. Cloned: 2.8, 3.3, 3.8 kb transcripts (different 5' ends) encoding predicted 523 aa, 679 aa, 854 aa proteins with similarity to collapsin??? Antibody stains all neuron processes in larvae and adults. [Hedgecock et al. 1985; Li et al. 1992; EH; SP] | |||||||||
| [Li W] mn260 is Tc4 insertion in exon VII of longest (3.8kb) unc-33 transcript. rh1030 same insertion site, modified Tc4 element. | |||||||||
| Strain (29) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Contained_in_operon | CEOP4092 | ||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00000963 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000964 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | unc-33 encodes a conserved member of the CRMP/TOAD/Ulip/DRP family of proteins that includes mammalian CRMP-2 (Collapsin response mediator protein-2), which is essential for axon guidance and axonogenesis; in C. elegans, unc-33 activity is required for several biological processes including outgrowth and guidance of sensory, motor, and interneurons, sex myoblast migration, normal body movement and morphology, egg laying, and defecation; by homology to CRMP-2, UNC-33 is predicted to bind tubulin heterodimers and promote microtubule assembly, thereby regulating the extension and branching of cellular projections during neuronal polarization; UNC-33 is reportedly expressed exclusively in axonal processes from after early embryogenesis through larval and adult stages. | Paper_evidence | WBPaper00001622 | |||||
| WBPaper00002665 | |||||||||
| WBPaper00004362 | |||||||||
| WBPaper00010044 | |||||||||
| WBPaper00025204 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 06 Jun 2005 00:00:00 | ||||||||
| Automated_description | Enables filamin binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including axon guidance; establishment or maintenance of cytoskeleton polarity; and regulation of locomotion. Located in neuron projection. Expressed in amphid socket cell; neuroblasts; neurons; pharyngeal cell; and somatic nervous system. Is an ortholog of human DPYSL2 (dihydropyrimidinase like 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y37E11C.1a | |||||||
| Y37E11C.1b | |||||||||
| Y37E11C.1c | |||||||||
| Corresponding_CDS_history | Y37E11C.1:wp82 | ||||||||
| Y37E11C.1a:wp145 | |||||||||
| Y37E11C.1b:wp145 | |||||||||
| Y37E11C.1c:wp145 | |||||||||
| Y37E11C.1c:wp273 | |||||||||
| Corresponding_transcript | Y37E11C.1a.1 | ||||||||
| Y37E11C.1b.1 | |||||||||
| Y37E11C.1c.1 | |||||||||
| Other_sequence (38) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00103588 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00020239 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00086120 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00055925 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00055924 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089774 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090316 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00030274 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090157 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089998 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00001590 | ||||||||
| WBCnstr00001591 | |||||||||
| WBCnstr00006869 | |||||||||
| Construct_product (15) | |||||||||
| Antibody | WBAntibody00000953 | ||||||||
| WBAntibody00000954 | |||||||||
| WBAntibody00001546 | |||||||||
| WBAntibody00001788 | |||||||||
| WBAntibody00001922 | |||||||||
| WBAntibody00002299 | |||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (148) | |||||||||
| Interaction (69) | |||||||||
| WBProcess | WBbiopr:00000010 | ||||||||
| Map_info | Map | IV | Position | -3.30458 | Error | 0.013709 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mDp4 | |||||||
| Positive_clone | EH#143 | ||||||||
| Y37E11 | |||||||||
| Y37E11C | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 99 | |||||||
| 484 | |||||||||
| 824 | |||||||||
| 1643 | |||||||||
| 3276 | |||||||||
| Multi_point (15) | |||||||||
| Pos_neg_data | 9110 | ||||||||
| Reference (123) | |||||||||
| Remark | extracted from Li et al. (1992) | ||||||||
| sequence match was given and M57.b and.c but theses overlap with Y37E11C.c which has not been annotated yet. sdm 11/00. will probably acquire name Y37E11C.1 | |||||||||
| Method | Gene |
