WormBase Tree Display for Gene: WBGene00006781
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| WBGene00006781 | SMap | S_parent | Sequence | F30H5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-45 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F30H5.1 | ||||||||
| Molecular_name | F30H5.1 | ||||||||
| F30H5.1.1 | |||||||||
| CE01925 | |||||||||
| Other_name | CELE_F30H5.1 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | unc-45 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143087 | ||||||||
| Allele (249) | |||||||||
| Legacy_information | e286ts : at 25x limp paralysed Egl : muscle ultrastructure defective few thick filaments; males move better; at 20x slow at 15x wildtype. ES3 (adult 25x) ME0. NA > 5 (m94ts r450ts : all alleles are temperature sensitive but some have stronger 20x phenotype than e286). Null phenotype probably lethal. | ||||||||
| [C.elegansII] e286ts : at 25C limp paralysed Egl; muscle ultrastructure defective, few thick filaments; males move better; at 20C slow, at 15C wildtype. ES3 (adult 25C) ME0. OA>5: m94ts, r450ts, su2002 (some ts alleles have stronger 20C phenotype than e286). Also lethal Pat alleles: st601, st603,(limited development beyond two-fold,no pharyngeal pumping, failure to assemble thick filaments), st604 (weaker allele, some maternal rescue), wc2, wc4, wc5. [Venolia and Waterston 1990; LV] | |||||||||
| Strain (19) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00000500 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00015916 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00016375 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019893 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019983 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | unc-45 encodes a conserved, muscle-specific protein that contains an N-terminal TRP (tetratricopeptide repeat) and a C-terminal UCS (UNC-45-CRO1-She4p) domain; during body wall muscle development, UNC-45 activity is essential for proper thick filament formation and sarcomere organization; in addition, maternally provided UNC-45 is required for embryonic polarity, cytokinesis, and germline cellularization; in regulating muscle development, UNC-45 acts, as both a chaperone and an HSP-90 cochaperone, to control type II myosin folding and assembly into thick filaments; in regulating polarity, cytokinesis and germline cellularization, maternal UNC-45 is essential for normal functioning of the NMY-2 non-muscle myosin II; UNC-45 can physically interact with myosin, Hsp90, and NMY-2; UNC-45 levels, and hence activity, are controlled by a novel E3/E4-multiubiquitylation complex containing CDC-48, UFD-2, and CHN-1; in muscle cells, UNC-45 colocalizes with myosin heavy chain B to thick filaments; in the embryo, UNC-45 colocalizes with NMY-2 at the cell cortex and the cleavage furrow; UNC-45 localization at the cell cortex and cleavage furrow is dependent upon NMY-2. | Paper_evidence | WBPaper00000128 | |||||
| WBPaper00003423 | |||||||||
| WBPaper00003891 | |||||||||
| WBPaper00005090 | |||||||||
| WBPaper00024873 | |||||||||
| WBPaper00029296 | |||||||||
| WBPaper00031424 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 26 Jun 2008 00:00:00 | ||||||||
| Automated_description | Enables identical protein binding activity; protein folding chaperone; and ubiquitin protein ligase binding activity. Involved in several processes, including chaperone-mediated protein folding; egg-laying behavior; and sarcomere organization. Located in cell cortex and cleavage furrow. Expressed in body wall musculature and non-striated muscle. Human ortholog(s) of this gene implicated in cataract 43 and myofibrillar myopathy 11. Is an ortholog of human UNC45B (unc-45 myosin chaperone B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110259 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14304) | ||||
| DOID:0081338 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14304) | ||||||
| Molecular_info | Corresponding_CDS | F30H5.1 | |||||||
| Corresponding_transcript | F30H5.1.1 | ||||||||
| Other_sequence (58) | |||||||||
| Associated_feature | WBsf644916 | ||||||||
| WBsf717851 | |||||||||
| WBsf991073 | |||||||||
| WBsf991074 | |||||||||
| WBsf1014077 | |||||||||
| WBsf1014078 | |||||||||
| WBsf1014079 | |||||||||
| WBsf1014080 | |||||||||
| WBsf224370 | |||||||||
| WBsf224371 | |||||||||
| Experimental_info | RNAi_result (34) | ||||||||
| Expr_pattern | Expr1270 | ||||||||
| Expr2733 | |||||||||
| Expr2734 | |||||||||
| Expr3114 | |||||||||
| Expr1013782 | |||||||||
| Expr1032853 | |||||||||
| Expr1149872 | |||||||||
| Expr2017878 | |||||||||
| Expr2036014 | |||||||||
| Drives_construct | WBCnstr00004615 | ||||||||
| WBCnstr00004616 | |||||||||
| WBCnstr00006321 | |||||||||
| WBCnstr00010185 | |||||||||
| WBCnstr00010924 | |||||||||
| WBCnstr00034156 | |||||||||
| Construct_product (27) | |||||||||
| Antibody | WBAntibody00002802 | ||||||||
| WBAntibody00002810 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (115) | |||||||||
| Interaction (64) | |||||||||
| Map_info | Map | III | Position | -26.8249 | Error | 0.015687 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F30H5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| W10B10 | |||||||||
| Mapping_data | 2_point (12) | ||||||||
| Multi_point (41) | |||||||||
| Pos_neg_data | 5743 | ||||||||
| Landmark_gene | |||||||||
| Reference (117) | |||||||||
| Method | Gene |
