| WBGene00006781 | SMap | S_parent | Sequence | F30H5 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | unc-45 | Person_evidence | WBPerson261 |
| | | Sequence_name | F30H5.1 |
| | | Molecular_name | F30H5.1 |
| | | | F30H5.1.1 |
| | | | CE01925 |
| | | Other_name | CELE_F30H5.1 | Accession_evidence | NDB | BX284603 |
| | | Public_name | unc-45 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143087 |
| | Allele (249) |
| | Legacy_information | e286ts : at 25x limp paralysed Egl : muscle ultrastructure defective few thick filaments; males move better; at 20x slow at 15x wildtype. ES3 (adult 25x) ME0. NA > 5 (m94ts r450ts : all alleles are temperature sensitive but some have stronger 20x phenotype than e286). Null phenotype probably lethal. |
| | | [C.elegansII] e286ts : at 25C limp paralysed Egl; muscle ultrastructure defective, few thick filaments; males move better; at 20C slow, at 15C wildtype. ES3 (adult 25C) ME0. OA>5: m94ts, r450ts, su2002 (some ts alleles have stronger 20C phenotype than e286). Also lethal Pat alleles: st601, st603,(limited development beyond two-fold,no pharyngeal pumping, failure to assemble thick filaments), st604 (weaker allele, some maternal rescue), wc2, wc4, wc5. [Venolia and Waterston 1990; LV] |
| | Strain (19) |
| | RNASeq_FPKM (74) |
| | GO_annotation (25) |
| | Ortholog (43) |
| | Paralog | WBGene00000500 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00015916 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00016375 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00019893 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00019983 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | unc-45 encodes a conserved, muscle-specific protein that contains an N-terminal TRP (tetratricopeptide repeat) and a C-terminal UCS (UNC-45-CRO1-She4p) domain; during body wall muscle development, UNC-45 activity is essential for proper thick filament formation and sarcomere organization; in addition, maternally provided UNC-45 is required for embryonic polarity, cytokinesis, and germline cellularization; in regulating muscle development, UNC-45 acts, as both a chaperone and an HSP-90 cochaperone, to control type II myosin folding and assembly into thick filaments; in regulating polarity, cytokinesis and germline cellularization, maternal UNC-45 is essential for normal functioning of the NMY-2 non-muscle myosin II; UNC-45 can physically interact with myosin, Hsp90, and NMY-2; UNC-45 levels, and hence activity, are controlled by a novel E3/E4-multiubiquitylation complex containing CDC-48, UFD-2, and CHN-1; in muscle cells, UNC-45 colocalizes with myosin heavy chain B to thick filaments; in the embryo, UNC-45 colocalizes with NMY-2 at the cell cortex and the cleavage furrow; UNC-45 localization at the cell cortex and cleavage furrow is dependent upon NMY-2. | Paper_evidence | WBPaper00000128 |
| | | | | | WBPaper00003423 |
| | | | | | WBPaper00003891 |
| | | | | | WBPaper00005090 |
| | | | | | WBPaper00024873 |
| | | | | | WBPaper00029296 |
| | | | | | WBPaper00031424 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 26 Jun 2008 00:00:00 |
| | | Automated_description | Enables identical protein binding activity; protein folding chaperone; and ubiquitin protein ligase binding activity. Involved in several processes, including chaperone-mediated protein folding; egg-laying behavior; and sarcomere organization. Located in cell cortex and cleavage furrow. Expressed in body wall musculature and non-striated muscle. Human ortholog(s) of this gene implicated in cataract 43 and myofibrillar myopathy 11. Is an ortholog of human UNC45B (unc-45 myosin chaperone B). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0110259 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14304) |
| | | DOID:0081338 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14304) |
| Molecular_info | Corresponding_CDS | F30H5.1 |
| | Corresponding_transcript | F30H5.1.1 |
| | Other_sequence (58) |
| | Associated_feature | WBsf644916 |
| | | WBsf717851 |
| | | WBsf991073 |
| | | WBsf991074 |
| | | WBsf1014077 |
| | | WBsf1014078 |
| | | WBsf1014079 |
| | | WBsf1014080 |
| | | WBsf224370 |
| | | WBsf224371 |
| Experimental_info | RNAi_result (34) |
| | Expr_pattern | Expr1270 |
| | | Expr2733 |
| | | Expr2734 |
| | | Expr3114 |
| | | Expr1013782 |
| | | Expr1032853 |
| | | Expr1149872 |
| | | Expr2017878 |
| | | Expr2036014 |
| | Drives_construct | WBCnstr00004615 |
| | | WBCnstr00004616 |
| | | WBCnstr00006321 |
| | | WBCnstr00010185 |
| | | WBCnstr00010924 |
| | | WBCnstr00034156 |
| | Construct_product (27) |
| | Antibody | WBAntibody00002802 |
| | | WBAntibody00002810 |
| | Microarray_results (23) |
| | Expression_cluster | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_CoreEnriched |
| | | WBPaper00037950:bodywall-muscle_embryo_enriched |
| | | WBPaper00037950:bodywall-muscle_embryo_SelectivelyEnriched |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00044030:nhr-8(hd117)_downregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045460:pept-1(lg601)_downregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:body-wall-muscle_nucleus_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053254:hsp-90(RNAi)_upregulated_protein |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053810:isp-1(qm150)_downregulated |
| | | WBPaper00053814:25C_downregulated_PY79 |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056284:ints-5(RNAi)_downregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056809:smn-1(ok355)_downregulated |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057154:HeatShock_downregulated_miRNA-target |
| | | WBPaper00057154:HeatShock_upregulated_mRNA |
| | | WBPaper00057288:Cold_downregulated_protein |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058969:RIS_depleted |
| | | WBPaper00060014:set-2(zr2012)_upregulated |
| | | WBPaper00061340:BWM_anterior |
| | | WBPaper00061340:Intestinal_and_rectal_muscle |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:tag-266-cand-1_14017 |
| | | WBPaper00061527:utx-1_2886-swan-1_2192 |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062590:Aging_downregulated_body-wall-muscle |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064130:Beta-Amyloid_upregulated_protein |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064315:mes-3(bn199)_downregulated_EGCs |
| | | WBPaper00064315:mes-3(bn199)_downregulated_PGCs |
| | | WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | cgc4386_cluster_5_1 |
| | | cgc4489_group_7 |
| | | cgc4489_group_14 |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00031003:0hr_muscle_enriched |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_3h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-exposed_3h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00047070:N2_starvation_downregulated |
| | | WBPaper00047070:xpa-1_UV_downregulated |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | Interaction (64) |
| Map_info | Map | III | Position | -26.8249 | Error | 0.015687 |
| | Well_ordered |
| | Positive | Positive_clone | F30H5 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | W10B10 |
| | Mapping_data | 2_point (12) |
| | | Multi_point (41) |
| | | Pos_neg_data | 5743 |
| | Landmark_gene |
| Reference (117) |
| Method | Gene |
