WormBase Tree Display for Gene: WBGene00006819
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| WBGene00006819 | Evidence | Paper_evidence | WBPaper00002036 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| WBPaper00004578 | |||||||||
| SMap | S_parent | Sequence | F08B6 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-87 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F08B6.4 | ||||||||
| Molecular_name | F08B6.4a | ||||||||
| F08B6.4a.1 | |||||||||
| CE20658 | |||||||||
| F08B6.4b | |||||||||
| CE27922 | |||||||||
| F08B6.4b.1 | |||||||||
| Other_name | CELE_F08B6.4 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | unc-87 | ||||||||
| DB_info | Database | AceView | gene | 1H338 | |||||
| WormQTL | gene | WBGene00006819 | |||||||
| WormFlux | gene | WBGene00006819 | |||||||
| NDB | locus_tag | CELE_F08B6.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006819|UniProtKB=P37806 | |||||||
| family | PTHR18959 | ||||||||
| NCBI | gene | 172397 | |||||||
| RefSeq | protein | NM_001025922.6 | |||||||
| NM_001025921.5 | |||||||||
| SwissProt | UniProtAcc | P37806 | |||||||
| TREEFAM | TREEFAM_ID | TF318550 | |||||||
| UniProt_GCRP | UniProtAcc | P37806 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143839 | ||||||||
| Allele (67) | |||||||||
| Legacy_information | e1216 : limp paralysed or very sluggish; somewhat Egl; larvae more paralysed; abnormal body muscle birefringence and ultrastructure thin filaments in small bundles. ES3 ME0. NA > 10 (e1459amber (phenotype more severe than e1216) st39 r320 etc.). | ||||||||
| See also e1216 | |||||||||
| [C.elegansII] e1216 : limp paralysed or very sluggish; somewhat Egl; larvae more paralysed; abnormal body muscle birefringence and ultrastructure, thin filaments in small bundles. ES3 ME0. OA>10: e1459amb (phenotype more severe than e1216), st39 r320 etc. Cloned: encodes predicted 40 kD protein with similarities to vertebrate smooth muscle proteins calponin, Drosophila mp20; localized to I bands. Alternative splicing. [Waterston et al. 1980; Goetinck and Waterston 1994;RW] | |||||||||
| Strain | WBStrain00027141 | ||||||||
| WBStrain00033504 | |||||||||
| WBStrain00033505 | |||||||||
| WBStrain00004273 | |||||||||
| WBStrain00004336 | |||||||||
| WBStrain00006225 | |||||||||
| WBStrain00006264 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Ortholog (31) | |||||||||
| Paralog | WBGene00000777 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000778 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00019361 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00020808 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00016898 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000779 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00000780 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | unc-87 encodes, through alternative splicing, two proteins that are required to maintain the structure of myofilaments in body wall muscle cells; UNC-87 proteins resemble the C-terminal repeat region of calponin but have no obvious orthologs outside of nematodes; in vitro, UNC-87 proteins exist as monomers in solution, associate with thin (F-actin) filaments but not with monomeric G-actin, and bundle F-actin filaments; in vivo, UNC-87 proteins reside in the I-band of bodywall muscle, and GFP-tagged UNC-87 associates with actin stress fibers; unc-87 mutants show degeneration of myofilaments, are profoundly immobile, and have noticeable defects in egg-laying; the unc-87 mutant phenotype is partially suppressed by the unc-54(s95) mutation, which lowers myosin activity but leaves myofilaments intact, indicating that UNC-87 prevents damage by mechanical stress on myofilaments. | Paper_evidence | WBPaper00002035 | |||||
| WBPaper00002036 | |||||||||
| WBPaper00004578 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables actin filament binding activity; cytoskeletal motor inhibitor activity; and myosin binding activity. Involved in actin cytoskeleton organization and negative regulation of muscle filament sliding. Located in I band; stress fiber; and striated muscle thin filament. Part of actomyosin, myosin complex part. Expressed in several structures, including non-striated muscle; pharynx; spermatheca; ventral ganglion; and vulva. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F08B6.4a | |||||||
| F08B6.4b | |||||||||
| Corresponding_CDS_history | F08B6.4c:wp248 | ||||||||
| Corresponding_transcript | F08B6.4a.1 | ||||||||
| F08B6.4b.1 | |||||||||
| Other_sequence (447) | |||||||||
| Associated_feature | WBsf983993 | ||||||||
| WBsf983994 | |||||||||
| WBsf983995 | |||||||||
| WBsf219635 | |||||||||
| WBsf219636 | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern | Expr2746 | ||||||||
| Expr4808 | |||||||||
| Expr4809 | |||||||||
| Expr12512 | |||||||||
| Expr12513 | |||||||||
| Expr1015918 | |||||||||
| Expr1032884 | |||||||||
| Expr1147950 | |||||||||
| Expr2017916 | |||||||||
| Expr2036052 | |||||||||
| Drives_construct | WBCnstr00021434 | ||||||||
| WBCnstr00021435 | |||||||||
| WBCnstr00034137 | |||||||||
| Construct_product | WBCnstr00034137 | ||||||||
| Antibody | WBAntibody00000969 | ||||||||
| WBAntibody00001283 | |||||||||
| WBAntibody00001540 | |||||||||
| Microarray_results (39) | |||||||||
| Expression_cluster (223) | |||||||||
| Interaction (49) | |||||||||
| Map_info | Map | I | Position | 1.31315 | Error | 0.000496 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | qDf16 | |||||||
| Positive_clone | F08B6 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| K01B11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 12 | |||||||
| Multi_point | 18 | ||||||||
| 19 | |||||||||
| 250 | |||||||||
| 251 | |||||||||
| 310 | |||||||||
| 346 | |||||||||
| 1447 | |||||||||
| 1891 | |||||||||
| 1892 | |||||||||
| 4602 | |||||||||
| Pos_neg_data | 5351 | ||||||||
| 6549 | |||||||||
| 6580 | |||||||||
| 8508 | |||||||||
| Reference (46) | |||||||||
| Method | Gene |
