WormBase Tree Display for Gene: WBGene00006845

WBGene00006845 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F11C3
  Identity: Version: 1
    Name: CGC_name: unc-122 Person_evidence: WBPerson261
      Sequence_name: F11C3.2
      Molecular_name: F11C3.2
        F11C3.2.1
        CE51321
      Other_name: ofm-1
        cof-1 CGC_data_submission
        CELE_F11C3.2 Accession_evidence: NDB BX284601
      Public_name: unc-122
    DB_info: Database: AceView gene 1P467
        WormQTL gene WBGene00006845
        WormFlux gene WBGene00006845
        NDB locus_tag CELE_F11C3.2
        Panther gene CAEEL|WormBase=WBGene00006845|UniProtKB=G5EGP1
          family PTHR23192
        NCBI gene 173359
        RefSeq protein NM_001322696.3
        TrEMBL UniProtAcc G5EGP1
        UniProt_GCRP UniProtAcc G5EGP1
        OMIM gene 608603
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Allele (81)
    Possibly_affected_by: WBVar02158832
    Legacy_information: [C.elegansII] e2520 : medium coiler at all stages. Moves forward well when stimulated, tends to coil up when moving backwards or at rest. Coiling usually ventral, occasionally dorsal. ES2 ME1/ME2. NA1. [CB]
    Complementation_data: [Hodgkin JA] complements aex-5(sa23), unc-100(su149)
    Strain (13)
    RNASeq_FPKM (74)
    GO_annotation: 00020596
      00020597
      00020598
      00020599
      00020600
      00020601
      00020602
      00020603
      00020604
      00020605
    Ortholog: WBGene00060887 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00038898 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00152160 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00132561 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00104188 Pristionchus pacificus From_analysis: Inparanoid_8
      WBGene00223567 Brugia malayi From_analysis: WormBase-Compara
      CSP21.g5711 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g19748 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g8262 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g13382 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g22982 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g9263 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g22104 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g9216 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g12499 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00265.g8134 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-unc-122 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g18982 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_02318.g25949 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_09139 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_001458 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12064 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g16539 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10010510 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g2984 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00237993 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00260092 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00287578 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0030887 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-2882 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-040426-2402 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-040718-194 Danio rerio From_analysis: OrthoFinder
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-050425-2 Danio rerio From_analysis: OrthoFinder
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-041014-329 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-070912-606 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-080219-11 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070912-266 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-050119-4 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
      ZFIN:ZDB-GENE-081105-107 Danio rerio From_analysis: OrthoFinder
            OrthoInspector
            Panther
      HGNC:17187 Homo sapiens From_analysis: OrthoFinder
            OrthoInspector
            Panther
      HGNC:24558 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:17189 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
      HGNC:17990 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      HGNC:27270 Homo sapiens From_analysis: OrthoFinder
            Panther
            SonicParanoid
      HGNC:29514 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
      MGI:2387329 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      MGI:2388361 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:3045350 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
      MGI:2443310 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      RGD:620430 Rattus norvegicus From_analysis: OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:620320 Rattus norvegicus From_analysis: OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:628672 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            SonicParanoid
      RGD:1311651 Rattus norvegicus From_analysis: OrthoFinder
            Panther
            SonicParanoid
      RGD:1309257 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            SonicParanoid
      RGD:1309741 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:727879 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
    Paralog: WBGene00000583 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00008543 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: unc-122 encodes a type II transmembrane protein with extracellular collagen-like repeats and a highly conserved olfactomedin (OLF) domain that is found in a family of secreted proteins involved in formation and function of nervous systems; UNC-122 negatively regulates cholinergic neuromuscular synaptic transmission, and is required for normal locomotion and morphology of the DVB motorneuron; mosaic analysis indicates that UNC-122 acts in muscle cells to regulate synaptic transmission and locomotory behavior; UNC-122 expression is observed in body wall muscle cells and the coelomocytes; in body wall muscles, UNC-122 localizes to the postsynaptic neuromuscular junction. Paper_evidence: WBPaper00002665
            WBPaper00012807
            WBPaper00006427
          Curator_confirmed: WBPerson1843
          Date_last_updated: 13 Jul 2015 00:00:00
      Automated_description: Involved in negative regulation of cholinergic synaptic transmission. Located in postsynaptic membrane. Expressed in body wall musculature and coelomocyte. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Is an ortholog of human GLDN (gliomedin) and OLFML2B (olfactomedin like 2B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060558 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:29514)
  Molecular_info (5)
  Experimental_info: RNAi_result: WBRNAi00030818 Inferred_automatically: RNAi_primary
      WBRNAi00089931 Inferred_automatically: RNAi_primary
      WBRNAi00090091 Inferred_automatically: RNAi_primary
      WBRNAi00044367 Inferred_automatically: RNAi_primary
      WBRNAi00089796 Inferred_automatically: RNAi_primary
      WBRNAi00090249 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram626
      Chronogram1379
      Expr2859
      Expr2860
      Expr5736
      Expr1029064
      Expr1032902
      Expr1148310
      Expr2017844
      Expr2035980
    Drives_construct (68)
    Construct_product: WBCnstr00010990
      WBCnstr00034124
    Microarray_results (19)
    Expression_cluster (90)
    Interaction: WBInteraction000002346
      WBInteraction000002347
      WBInteraction000002348
      WBInteraction000031893
      WBInteraction000031895
      WBInteraction000031896
      WBInteraction000166446
      WBInteraction000166447
      WBInteraction000166448
      WBInteraction000364445
    Anatomy_function: WBbtf0275
      WBbtf0276
      WBbtf0277
      WBbtf0278
      WBbtf1052
      WBbtf1053
  Map_info: Map: I Position: 27.9705 Error: 0.034616
    Well_ordered
    Positive: Positive_clone: F11C3 Person_evidence: WBPerson385
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 6015
      Multi_point: 4455
      Pos_neg_data: 5950
        5951
        5952
        5953
        5954
  Reference (20)
  Remark: [Hodgkin JA] extracted from complex strain CB3337, isolated by Hedgecock EM
    Sequence connection from [Loria P, Hobert O]
  Method: Gene