WormBase Tree Display for Gene: WBGene00012936

WBGene00012936 SMap: S_parent: Sequence: Y47D3A
  Identity: Version: 2
    Name: CGC_name: pola-1 Person_evidence: WBPerson30546
      Sequence_name: Y47D3A.29
      Molecular_name: Y47D3A.29
        Y47D3A.29.1
        CE32262
      Other_name: CELE_Y47D3A.29 Accession_evidence: NDB BX284603
      Public_name: pola-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:54 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 05 Apr 2017 11:17:23 WBPerson2970 Name_change: CGC_name: pola-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pola
    Allele: WBVar00860793
      WBVar01771183
      WBVar00860794
      WBVar01409524
      WBVar00860795
      WBVar01409525
      WBVar01409526
      WBVar00860796
      WBVar01409527
      WBVar00860797
      WBVar00860798
      WBVar00860799
      WBVar01995755
      WBVar00860800
      WBVar01500260
      WBVar00860801
      WBVar00860802
      WBVar00860803
      WBVar00860804
      WBVar00860805
      WBVar00860806
      WBVar00860807
      WBVar00860808
      WBVar00860809
      WBVar00860810
      WBVar01448595
      WBVar00860811
      WBVar00860812
      WBVar00860813
      WBVar00860814
      WBVar00860815
      WBVar00253964
      WBVar00860816
      WBVar00860817
      WBVar00860818
      WBVar00860819
      WBVar00860820
      WBVar00860821
      WBVar00860822
      WBVar00860823
      WBVar00408818
      WBVar00408819
      WBVar00860824
      WBVar00408820
      WBVar00860825
      WBVar00408821
      WBVar00860826
      WBVar00408822
      WBVar00860827
      WBVar00860828
      WBVar00408823
      WBVar00860829
      WBVar00408824
      WBVar00860830
      WBVar00408825
      WBVar01919083
      WBVar00408826
      WBVar01334301
      WBVar01919084
      WBVar00860831
      WBVar00408827
      WBVar01334302
      WBVar01919086
      WBVar00860832
      WBVar00408828
      WBVar01919087
      WBVar01334307
      WBVar00860833
      WBVar01919088
      WBVar00860834
      WBVar00408829
      WBVar00408830
      WBVar00860835
      WBVar00860836
      WBVar00408831
      WBVar00860837
      WBVar00408832
      WBVar00408833
      WBVar00860838
      WBVar00408834
      WBVar00860839
      WBVar01507693
      WBVar00860840
      WBVar00408835
      WBVar00408836
      WBVar01507694
      WBVar00860841
      WBVar00408837
      WBVar00860842
      WBVar01507695
      WBVar00408838
      WBVar00860843
      WBVar01507696
      WBVar00860844
      WBVar00408839
      WBVar01416491
      WBVar00860845
      WBVar00408840
      WBVar00860846
      WBVar00408841
      WBVar00860847
      WBVar01607277
      WBVar01607278
      WBVar01480440
      WBVar01480441
      WBVar01480442
      WBVar01269238
      WBVar01269240
      WBVar01269241
      WBVar01269242
      WBVar01269243
      WBVar01269244
      WBVar01269245
      WBVar01269246
      WBVar01269247
      WBVar01269248
      WBVar01269249
      WBVar01499774
      WBVar01269252
      WBVar01269253
      WBVar01269254
      WBVar01269255
      WBVar01269256
      WBVar01269257
      WBVar02074236
      WBVar00257709
      WBVar01397518
      WBVar01397519
      WBVar01397520
      WBVar01397521
      WBVar01397522
      WBVar01397524
      WBVar00217483
      WBVar02053500
      WBVar02081703
      WBVar00270034
      WBVar02156423
      WBVar01984123
      WBVar02132734
      WBVar02132735
      WBVar01723650
      WBVar01723651
      WBVar00258143
      WBVar01963150
      WBVar01401865
      WBVar00860784
      WBVar00860785
      WBVar01401868
      WBVar00179449
      WBVar00860786
      WBVar01401869
      WBVar00860787
      WBVar00179450
      WBVar00860788
      WBVar01409518
      WBVar00860789
      WBVar01409519
      WBVar01409520
      WBVar00860790
      WBVar01409521
      WBVar02118940
      WBVar00860791
      WBVar00860792
      WBVar01409522
    Strain: WBStrain00051196
    RNASeq_FPKM (74)
    GO_annotation (27)
    Contained_in_operon: CEOP3720
    Ortholog (42)
    Paralog: WBGene00008645 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021344 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: Y47D3A.29 encodes the catalytic subunit of DNA polymerase alpha; large-scale RNAi screens indicate that Y47D3A.29 activity is essential for embryogenesis and required specifically for normal pronuclear migration, as well as normal nuclear position and cell division timing in early blastomeres. Paper_evidence: WBPaper00005654
            WBPaper00006395
            WBPaper00025054
          Curator_confirmed: WBPerson1843
          Date_last_updated: 06 Apr 2007 00:00:00
      Automated_description: Predicted to enable DNA binding activity; DNA-directed DNA polymerase activity; and chromatin binding activity. Predicted to be involved in lagging strand elongation; leading strand elongation; and mitotic DNA replication initiation. Predicted to be located in nucleus. Predicted to be part of alpha DNA polymerase:primase complex. Human ortholog(s) of this gene implicated in Van Esch-O'Driscoll syndrome and X-linked reticulate pigmentary disorder. Is an ortholog of human POLA1 (DNA polymerase alpha 1, catalytic subunit). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111840 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9173)
      DOID:0111834 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9173)
  Molecular_info: Corresponding_CDS: Y47D3A.29
    Corresponding_CDS_history: Y47D3A.29:wp89
      Y47D3A.29b:wp279
    Corresponding_transcript: Y47D3A.29.1
    Other_sequence (28)
    Associated_feature: WBsf645602
      WBsf645603
      WBsf659569
      WBsf659570
      WBsf1015933
      WBsf1015934
      WBsf225798
  Experimental_info: RNAi_result: WBRNAi00075442 Inferred_automatically: RNAi_primary
      WBRNAi00026719 Inferred_automatically: RNAi_primary
      WBRNAi00009341 Inferred_automatically: RNAi_primary
      WBRNAi00056755 Inferred_automatically: RNAi_primary
      WBRNAi00026720 Inferred_automatically: RNAi_primary
      WBRNAi00097143 Inferred_automatically: RNAi_primary
      WBRNAi00114561 Inferred_automatically: RNAi_primary
      WBRNAi00009342 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1012413
      Expr1035733
      Expr1160213
      Expr2014989
      Expr2033224
    Microarray_results (23)
    Expression_cluster (139)
    Interaction (123)
  Map_info: Map: III Position: 6.49087
    Positive: Positive_clone: Y47D3A Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00031307
    WBPaper00035228
    WBPaper00038491
    WBPaper00054520
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene