WormBase Tree Display for Variation: WBVar00142903

WBVar00142903 Evidence: Paper_evidence: WBPaper00033138
  Name: Public_name: e5
    Other_name (21)
    HGVSg: CHROMOSOME_X:g.15124688G>A
  Sequence_details: SMap: S_parent: Sequence: R07D5
    Flanking_sequences: tccacgtgaaatttattcgcgtagaaatcga aaattggctattaccaatgggtgccgtttat
    Mapping_target: R07D5
    Type_of_mutation: Substitution: c t Paper_evidence: WBPaper00033138
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00004076
      WBStrain00040856
      WBStrain00054742
      WBStrain00056070
    Laboratory: CB
      OJ
    Status: Live
  Affects: Gene: WBGene00006747
    Transcript (11)
    Interactor: WBInteraction000518923
      WBInteraction000518930
  Isolation: Mutagen: EMS
  Genetics: Interpolated_map_position: X 22.0113
    Mapping_data: In_2_point: 494
        3170
        3636
        6060
        6165
      In_multi_point: 419
        582
        583
        2417
        2783
        5472
  Description: Phenotype: WBPhenotype:0000002 Paper_evidence: WBPaper00033075
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: unc-7 mutant animals move in a rigid and twisted manner referred as "kinkers" Paper_evidence: WBPaper00033075
            Curator_confirmed: WBPerson2021
          kinker in forward movement, e5/Df similar, null phenotype. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00033075
            Person_evidence: WBPerson261
            Curator_confirmed: WBPerson2021
              WBPerson712
      WBPhenotype:0000017 Paper_evidence: WBPaper00033075
        Curator_confirmed: WBPerson2021
        Remark: unc-7 mutants were aldicarb resistant Paper_evidence: WBPaper00033075
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00033075
            Curator_confirmed: WBPerson2021
        Affected_by: Molecule: WBMol:00003650 Paper_evidence: WBPaper00033075
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000164 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: slightly thin, e5/Df similar, null phenotype. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000247 Paper_evidence: WBPaper00000214
        Curator_confirmed: WBPerson712
        Remark: Mutants behave like WT in a Na+ gradient assay; however, mutants are 40% responsive to Na+ in a behavior orientation assay. WT worms are 95% responsive (based on sustained distance from attractant). Paper_evidence: WBPaper00000214
            Curator_confirmed: WBPerson712
      WBPhenotype:0000254 Paper_evidence: WBPaper00000214
        Curator_confirmed: WBPerson712
        Remark: Mutants are 50% responsive to Cl- in behavior orientation assay (based on sustained distance from attractant), WT are 70% responsive. Paper_evidence: WBPaper00000214
            Curator_confirmed: WBPerson712
      WBPhenotype:0000324 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0000353 Paper_evidence: WBPaper00000214
        Curator_confirmed: WBPerson712
        Remark: Mutants mostly move backwards, even in the presence of an attractant. Forward motion is possible, all mutants can be prodded to go forward. Paper_evidence: WBPaper00000214
            Curator_confirmed: WBPerson712
      WBPhenotype:0000425 Paper_evidence: WBPaper00033075
        Curator_confirmed: WBPerson2021
        Remark: UNC-7 antibody staining is absent in mutants Paper_evidence: WBPaper00033075
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00033075
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000643 Paper_evidence: WBPaper00000031
          WBPaper00033138
        Curator_confirmed: WBPerson48
          WBPerson621
      WBPhenotype:0000847 Paper_evidence: WBPaper00033075
        Curator_confirmed: WBPerson2021
        Remark: unc-7 is required for the even distribution of GFP::SYD-2 and UNC-10 active zone markers Paper_evidence: WBPaper00033075
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00033075
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001005 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0001639 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0001716 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0001727 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002284 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002288 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002292 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002294 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002298 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002301 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002308 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002312 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002323 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002335 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002347 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002348 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002548 Paper_evidence: WBPaper00040432
        Curator_confirmed: WBPerson720
        Remark: uncoordinated forward and reversal body bend propagation Paper_evidence: WBPaper00040432
            Curator_confirmed: WBPerson720
      WBPhenotype:0002549 Paper_evidence: WBPaper00040432
        Curator_confirmed: WBPerson720
        Remark: frequent spontaneous short reversals that interrupt forward movement. Overtime the animal exhibits slow reversals Paper_evidence: WBPaper00040432
            Curator_confirmed: WBPerson720
      WBPhenotype:0002550 Paper_evidence: WBPaper00040432
        Curator_confirmed: WBPerson720
        Remark: over half of the time, animals exhibit a 'pause'-like state - a pulled mid-body posture when head and tail actively pull the anterior and posterior bodies into opposite directions. Overtime the animal exhibits slow reversals Paper_evidence: WBPaper00040432
            Curator_confirmed: WBPerson720
      WBPhenotype:0004017 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: moves backward better than forward, e5/Df similar, null phenotype. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Ease_of_scoring: ES3_Easy_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0004022 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
    Phenotype_not_observed: WBPhenotype:0000637 Paper_evidence: WBPaper00000214
        Curator_confirmed: WBPerson712
      WBPhenotype:0000641 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: active, healthy, e5/Df similar, null phenotype. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000672 Paper_evidence: WBPaper00033075
        Curator_confirmed: WBPerson2021
        Remark: The synaptic vesicle markers (SNB-1::GFP and SNG-1::GFP) showed normal morphology, as well as normal number and distribution of dorsal or lateral cord puncta in unc-7 animals Paper_evidence: WBPaper00033075
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00033075
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001323 Paper_evidence: WBPaper00033075
        Curator_confirmed: WBPerson2021
        Remark: The synaptic vesicle markers (SNB-1::GFP and SNG-1::GFP) showed normal morphology, as well as normal number and distribution of dorsal or lateral cord puncta in unc-7 animals Paper_evidence: WBPaper00033075
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00033075
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001669 Paper_evidence: WBPaper00033075
        Curator_confirmed: WBPerson2021
        Remark: The synaptic vesicle markers (SNB-1::GFP and SNG-1::GFP) showed normal morphology, as well as normal number and distribution of dorsal or lateral cord puncta in unc-7 animals Paper_evidence: WBPaper00033075
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00033075
            Curator_confirmed: WBPerson2021
      WBPhenotype:0002014 Paper_evidence: WBPaper00027055
        Curator_confirmed: WBPerson557
        Remark: unc-7(e5) did not inhibit the electrical coupling of body wall muscle cells. Paper_evidence: WBPaper00027055
            Curator_confirmed: WBPerson557
  Reference (11)
  Method: Substitution_allele