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WormBase Tree Display for Gene: WBGene00002991

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Name Class

WBGene00002991SMapS_parentSequenceF17E5
IdentityVersion1
NameCGC_namelin-2Person_evidenceWBPerson261
Sequence_nameF17E5.1
Molecular_nameF17E5.1a
F17E5.1a.1
CE27131
F17E5.1b
CE27132
F17E5.1b.1
Other_nameCELE_F17E5.1Accession_evidenceNDBBX284606
Public_namelin-2
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:30WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlin
Reference_alleleWBVar00143908
AlleleWBVar00143908Inferred_automaticallyFrom strain object: CB1309
From strain object: EU149
From strain object: EU1513
From strain object: EU1514
From strain object: EU407
From strain object: EU822
From strain object: EU924
From strain object: EU931
From strain object: MT491
From strain object: SP1377
WBVar00089278Inferred_automaticallyFrom strain object: MT105
WBVar00090221Inferred_automaticallyFrom strain object: MT3881
WBVar00089485Inferred_automaticallyFrom strain object: MT397
WBVar00089739
WBVar00090153
WBVar00089658
WBVar00144005
WBVar00089662
WBVar00090105
WBVar00144012
WBVar00143905
WBVar00000026
WBVar00089295
WBVar00143998
WBVar00089406
WBVar00089925
WBVar00089469
WBVar00090104
WBVar02159330
WBVar00519556
WBVar01571411
WBVar01194519
WBVar01571412
WBVar01194520
WBVar00519557
WBVar01835075
WBVar00519558
WBVar01194521
WBVar01571413
WBVar01499887
WBVar01194522
WBVar00519559
WBVar01835076
WBVar01571414
WBVar00519560
WBVar01835077
WBVar01194523
WBVar01571415
WBVar01499888
WBVar01194524
WBVar01571416
WBVar00519561
WBVar01571417
WBVar00519562
WBVar01194525
WBVar00519563
WBVar01571418
WBVar01194526
WBVar00519564
WBVar01194527
WBVar01194528
WBVar00519565
WBVar01499710
WBVar00259480
WBVar01825985
WBVar01471615
WBVar01490337
WBVar01471616
WBVar01471617
WBVar01889196
WBVar01897949
WBVar01954684
WBVar01954685
WBVar01954686
WBVar02078283
WBVar00274559
WBVar00274560
WBVar02027477
WBVar01981433
WBVar01981434
WBVar01981435
WBVar00599192
WBVar00599193
WBVar01621642
WBVar01621643
WBVar00083540
WBVar01787141
WBVar00603616
WBVar00083541
WBVar01787142
WBVar02045250
WBVar00083542
WBVar01787143
WBVar00083543
WBVar01787144
WBVar00083544
WBVar00083545
WBVar01787145
WBVar00083546
WBVar01787146
WBVar01787147
WBVar01914265
WBVar01194419
WBVar01787148
WBVar01194420
WBVar01787149
WBVar01787150
WBVar01194421
WBVar01787151
WBVar01194422
WBVar01194423
WBVar01787152
WBVar01194424
WBVar01787153
WBVar01194425
WBVar01787154
WBVar01194426
WBVar01787155
WBVar01194427
WBVar01787156
WBVar01194428
WBVar01787157
WBVar01194429
WBVar01787158
WBVar01194430
WBVar01787159
WBVar01194431
WBVar01787160
WBVar01194432
WBVar01194433
WBVar01194434
WBVar01194435
WBVar01194436
WBVar01194437
WBVar01194438
WBVar01194439
WBVar01194440
WBVar01194441
WBVar01194442
WBVar01194443
WBVar01194444
WBVar02140264
WBVar01194445
WBVar01987977
WBVar01194446
WBVar01194447
WBVar01194448
WBVar01194449
WBVar01194450
WBVar01194451
WBVar01194452
WBVar01194453
WBVar01194454
WBVar01194455
WBVar01194456
WBVar01194457
WBVar01194458
WBVar01194459
WBVar01194460
WBVar01194461
WBVar01194462
WBVar00244279
WBVar00244280
WBVar01194463
WBVar00244282
WBVar01194464
WBVar01194465
WBVar01194466
WBVar02119809
WBVar01194467
WBVar01194468
WBVar01194469
WBVar01194470
WBVar01194471
WBVar01194472
WBVar01194473
WBVar01194474
WBVar01194475
WBVar01194476
WBVar01194477
WBVar01194478
WBVar01194479
WBVar01816886
WBVar01194480
WBVar01816887
WBVar01194481
WBVar01194482
WBVar01194483
WBVar01194484
WBVar01194485
WBVar01194486
WBVar01194487
WBVar01194488
WBVar01194489
WBVar02034758
WBVar01194490
WBVar02034759
WBVar01194491
WBVar02034760
WBVar02034761
WBVar01194492
WBVar01194493
WBVar01194494
WBVar01194495
WBVar01194496
WBVar01194497
WBVar01194498
WBVar00519536
WBVar01194499
WBVar01194500
WBVar02148023
WBVar00519537
WBVar01194501
WBVar00519538
WBVar01194502
WBVar00519539
WBVar01194503
WBVar00519540
WBVar00519541
WBVar01194504
WBVar00519542
WBVar01194505
WBVar00519543
WBVar01194506
WBVar01194507
WBVar00519544
WBVar01194508
WBVar00519545
WBVar01194509
WBVar00519546
WBVar00519547
WBVar01194510
WBVar00519548
WBVar01194511
WBVar01194512
WBVar00519549
WBVar01194513
WBVar00519550
WBVar01571405
WBVar01571406
WBVar01194514
WBVar00519551
WBVar02009252
WBVar01194515
WBVar01498960
WBVar01571407
WBVar00519552
WBVar00519553
WBVar01194516
WBVar01571408
WBVar01194517
WBVar00519554
WBVar01571409
WBVar01500067
WBVar01571410
WBVar00519555
WBVar01194518
Possibly_affected_byWBVar02157232
Legacy_informatione1309 : adult hermaphrodite vulvaless (penetrance 93%); ES2 (adult)/ ES1 (larvae); HME2; adult male wildtype ME3. NA13 (e1453amber (non-null lower penetrance than e1309 50% vulvaless) n105ts (penetrance 24% at 15x 90% at 25x) n768 (weak allele multiple vulval protrusions penetrance 21%) etc.).
See also e1309, e1424, e1437, e1453, n105, n167, n305, n380, n670, n674, n768, n1052, n1297, n1298
[C.elegansII] e1309 : adult hermaphrodite vulvaless (penetrance 93%); ES2 (adult)/ ES1 (larvae); HME2; adult male wildtype ME3. NA13: e1453amb (non-null, lower penetrance than e1309, 50% vulvaless), n105ts (penetrance 24% at 15C, 90% at 25C) n768 (weak allele multiple vulval protrusions penetrance 21%), n397 (deletes most of gene), etc. Cloned: encodes predicted protein with PDZ domain,similarity to guanylate kinase, Drosophila discs large. Mutants delocalize LET-23. [Ferguson et al. 1985; SD; MT]
Strain (14)
RNASeq_FPKM (74)
GO_annotation (26)
Ortholog (43)
ParalogWBGene00006467Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00016841Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00021914Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
Structured_descriptionConcise_descriptionlin-2 encodes a protein belonging to the membrane associated guanylate kinase (MAGUK) family, with several domains (L27, PDZ, SH3, and guanylate kinase) thought to assemble specific multiprotein complexes in particular regions of the cell; in vivo, LIN-2 is required for the correct localization of LET-23 (and, presumably, other membrane proteins) to specific regions of the plasma membrane.Paper_evidenceWBPaper00000496
WBPaper00003215
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated31 Jan 2006 00:00:00
Automated_descriptionEnables insulin-like growth factor receptor binding activity. Involved in several processes, including egg-laying behavior; positive regulation of vulval development; and protein localization to membrane. Located in cell junction. Expressed in several structures, including CAN; HSN; isthmus; somatic nervous system; and vulval precursor cell. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Is an ortholog of human CASK (calcium/calmodulin dependent serine protein kinase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:0060041Homo sapiensPaper_evidenceWBPaper00048837
Curator_confirmedWBPerson324
Date_last_updated09 Feb 2018 00:00:00
Potential_modelDOID:0060807Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1497)
DOID:14711Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1497)
Models_disease_assertedWBDOannot00000474
Molecular_infoCorresponding_CDSF17E5.1a
F17E5.1b
Corresponding_CDS_historyF17E5.1a:wp47
F17E5.1b:wp47
Corresponding_transcriptF17E5.1a.1
F17E5.1b.1
Other_sequence (49)
Associated_feature (16)
Experimental_infoRNAi_resultWBRNAi00013468Inferred_automaticallyRNAi_primary
WBRNAi00030265Inferred_automaticallyRNAi_primary
WBRNAi00044888Inferred_automaticallyRNAi_primary
WBRNAi00000540Inferred_automaticallyRNAi_primary
WBRNAi00076312Inferred_automaticallyRNAi_primary
Expr_pattern (11)
Drives_constructWBCnstr00022290
WBCnstr00036300
Construct_productWBCnstr00012382
WBCnstr00021427
WBCnstr00036300
WBCnstr00038376
WBCnstr00038378
WBCnstr00041675
AntibodyWBAntibody00000973
WBAntibody00001507
Microarray_results (28)
Expression_cluster (169)
Interaction (292)
Map_infoMapXPosition7.04058Error0.007077
Well_ordered
PositiveInside_rearryDp11
Positive_cloneC43C10Inferred_automaticallyFrom sequence, transcript, pseudogene data
F17E5Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point168
280
281
Multi_point (25)
Pos_neg_data320
686
687
871
8424
8431
8443
8451
8457
Landmark_gene
ReferenceWBPaper00000444
WBPaper00000496
WBPaper00000500
WBPaper00000608
WBPaper00000762
WBPaper00000957
WBPaper00001185
WBPaper00001242
WBPaper00001292
WBPaper00001293
WBPaper00001404
WBPaper00001490
WBPaper00001719
WBPaper00001724
WBPaper00001736
WBPaper00001756
WBPaper00001794
WBPaper00001860
WBPaper00001868
WBPaper00002148
WBPaper00002211
WBPaper00002219
WBPaper00002366
WBPaper00002375
WBPaper00002382
WBPaper00002436
WBPaper00002477
WBPaper00002498
WBPaper00002617
WBPaper00002629
WBPaper00002656
WBPaper00002811
WBPaper00002916
WBPaper00002963
WBPaper00003085
WBPaper00003202
WBPaper00003203
WBPaper00003214
WBPaper00003215
WBPaper00003300
WBPaper00003329
WBPaper00003524
WBPaper00003632
WBPaper00003822
WBPaper00003839
WBPaper00003878
WBPaper00004293
WBPaper00004368
WBPaper00004408
WBPaper00004449
WBPaper00004634
WBPaper00004964
WBPaper00005343
WBPaper00005472
WBPaper00005571
WBPaper00005792
WBPaper00006103
WBPaper00006390
WBPaper00006462
WBPaper00006521
WBPaper00010463
WBPaper00010826
WBPaper00010911
WBPaper00011145
WBPaper00011626
WBPaper00013069
WBPaper00013902
WBPaper00013908
WBPaper00013920
WBPaper00014073
WBPaper00014191
WBPaper00014218
WBPaper00014324
WBPaper00014470
WBPaper00014517
WBPaper00014554
WBPaper00014556
WBPaper00014791
WBPaper00014795
WBPaper00014796
WBPaper00014830
WBPaper00014894
WBPaper00015211
WBPaper00015250
WBPaper00015291
WBPaper00015349
WBPaper00015440
WBPaper00015978
WBPaper00016251
WBPaper00016271
WBPaper00016279
WBPaper00016384
WBPaper00016880
WBPaper00016966
WBPaper00017091
WBPaper00017228
WBPaper00017285
WBPaper00017306
WBPaper00017313
WBPaper00017447
WBPaper00017463
WBPaper00017525
WBPaper00017743
WBPaper00018116
WBPaper00018126
WBPaper00018220
WBPaper00019646
WBPaper00020840
WBPaper00020852
WBPaper00020900
WBPaper00020919
WBPaper00020921
WBPaper00021791
WBPaper00021807
WBPaper00021860
WBPaper00022017
WBPaper00022293
WBPaper00022332
WBPaper00022414
WBPaper00022807
WBPaper00023121
WBPaper00023607
WBPaper00023785
WBPaper00024876
WBPaper00024993
WBPaper00025197
WBPaper00027009
WBPaper00027225
WBPaper00027245
WBPaper00027258
WBPaper00027265
WBPaper00027469
WBPaper00027555
WBPaper00027626
WBPaper00027681
WBPaper00028561
WBPaper00028808
WBPaper00029020
WBPaper00031095
WBPaper00032233
WBPaper00033189
WBPaper00033250
WBPaper00033282
WBPaper00033635
WBPaper00034261
WBPaper00034980
WBPaper00035163
WBPaper00036615
WBPaper00036826
WBPaper00036963
WBPaper00038491
WBPaper00038572
WBPaper00039125
WBPaper00041169
WBPaper00042706
WBPaper00042725
WBPaper00043613
WBPaper00045219
WBPaper00045882
WBPaper00048305
WBPaper00048837
WBPaper00049582
WBPaper00052225
WBPaper00055090
WBPaper00056292
WBPaper00057982
WBPaper00058219
WBPaper00059737
WBPaper00060988
WBPaper00061029
WBPaper00064615
WBPaper00064934
MethodGene