WormBase Tree Display for Gene: WBGene00006809

WBGene00006809 SMap: S_parent: Sequence: C11D2
  Identity: Version: 2
    Name: CGC_name: unc-77 Person_evidence: WBPerson261
      Sequence_name: C11D2.6
      Molecular_name (48)
      Other_name: nca-1 Paper_evidence: WBPaper00031592
          Person_evidence: WBPerson604
        CELE_C11D2.6 Accession_evidence: NDB BX284604
      Public_name: unc-77
    DB_info: Database: WormQTL gene WBGene00006809
        WormFlux gene WBGene00006809
        NDB locus_tag CELE_C11D2.6
        Panther gene CAEEL|WormBase=WBGene00006809|UniProtKB=V6CKM5
          family PTHR46141
        NCBI gene 177379
        RefSeq protein (16)
        TREEFAM TREEFAM_ID TF312843
        TrEMBL UniProtAcc (16)
        UniProt_GCRP UniProtAcc V6CKM5
        OMIM gene 611549
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 03 Dec 2009 11:55:50 WBPerson2970 Event: Acquires_merge: WBGene00003557
      Acquires_merge: WBGene00003557
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143348
    Allele: WBVar00426452
      WBVar01966344
      WBVar00914563
      WBVar00426453
      WBVar00914564
      WBVar01966345
      WBVar01966346
      WBVar00426454
      WBVar00914565
      WBVar01966347
      WBVar00914566
      WBVar00426455
      WBVar01966348
      WBVar00914567
      WBVar00426456
      WBVar01966349
      WBVar00914568
      WBVar00426457
      WBVar00914569
      WBVar00426458
      WBVar00426459
      WBVar00914570
      WBVar00914571
      WBVar00426460
      WBVar00426461
      WBVar00914572
      WBVar00426462
      WBVar00914573
      WBVar00426463
      WBVar00914574
      WBVar00250815
      WBVar02013512
      WBVar00426464
      WBVar00914575
      WBVar00914576
      WBVar00426465
      WBVar00914577
      WBVar00426466
      WBVar00426467
      WBVar00914578
      WBVar00426468
      WBVar00914579
      WBVar00426469
      WBVar00914580
      WBVar00426470
      WBVar00914581
      WBVar00914582
      WBVar00426471
      WBVar00914583
      WBVar00426472
      WBVar00914584
      WBVar01650010
      WBVar00426473
      WBVar00426474
      WBVar00914585
      WBVar00426475
      WBVar00914586
      WBVar00426476
      WBVar00914587
      WBVar00914588
      WBVar00145465
      WBVar00426477
      WBVar00914589
      WBVar00426478
      WBVar00914590
      WBVar00426479
      WBVar00914591
      WBVar00426480
      WBVar00914592
      WBVar00426481
      WBVar00426482
      WBVar00914593
      WBVar00426483
      WBVar00914594
      WBVar00426484
      WBVar00914595
      WBVar01499365
      WBVar00426485
      WBVar00914596
      WBVar00914597
      WBVar00426486
      WBVar02152194
      WBVar00426487
      WBVar00914598
      WBVar00914599
      WBVar00426488
      WBVar00426489
      WBVar00914600
      WBVar00426490
      WBVar00914601
      WBVar00914602
      WBVar00426491
      WBVar00914603
      WBVar00426492
      WBVar00914604
      WBVar00426493
      WBVar00914605
      WBVar00426494
      WBVar00914606
      WBVar00426495
      WBVar01818822
      WBVar00426496
      WBVar00914607
      WBVar00426497
      WBVar00914608
      WBVar00426498
      WBVar00914609
      WBVar00914610
      WBVar00426499
      WBVar00914611
      WBVar00426500
      WBVar00426501
      WBVar00914612
      WBVar00426502
      WBVar00914613
      WBVar00914614
      WBVar00914615
      WBVar01727815
      WBVar02020666
      WBVar00914616
      WBVar02020667
      WBVar01727816
      WBVar00914617
      WBVar00914618
      WBVar02020668
      WBVar01727817
      WBVar00914619
      WBVar01727818
      WBVar02020669
      WBVar01786385
      WBVar01727819
      WBVar00914620
      WBVar02020670
      WBVar00914621
      WBVar01727820
      WBVar01786386
      WBVar01727821
      WBVar00914622
      WBVar01786387
      WBVar00914623
      WBVar01727822
      WBVar00914624
      WBVar01727823
      WBVar01727824
      WBVar01990908
      WBVar02071773
      WBVar01727825
      WBVar01499395
      WBVar01727826
      WBVar01499396
      WBVar01727827
      WBVar01727828
      WBVar01727829
      WBVar01727830
      WBVar01727831
      WBVar01727832
      WBVar01727833
      WBVar01727834
      WBVar00275821
      WBVar02048251
      WBVar00189323
      WBVar00189324
      WBVar00189325
      WBVar00189326
      WBVar00189327
      WBVar00189328
      WBVar00189329
      WBVar00189330
      WBVar01481941
      WBVar01481942
      WBVar01481943
      WBVar01481944
      WBVar01481945
      WBVar00914477
      WBVar00914478
      WBVar00914479
      WBVar00914480
      WBVar00914481
      WBVar00914482
      WBVar00914483
      WBVar00914484
      WBVar01497964
      WBVar00914485
      WBVar00914486
      WBVar00914487
      WBVar00914488
      WBVar00914489
      WBVar00914490
      WBVar00914491
      WBVar01898954
      WBVar00914492
      WBVar00087918
      WBVar00914493
      WBVar00914494
      WBVar00914495
      WBVar01499633
      WBVar00914496
      WBVar02134002
      WBVar00914497
      WBVar00914498
      WBVar02134003
      WBVar00914499
      WBVar00914500
      WBVar00914501
      WBVar00914502
      WBVar00914503
      WBVar00914504
      WBVar01452692
      WBVar00914505
      WBVar01452693
      WBVar01668773
      WBVar00914506
      WBVar00914507
      WBVar01452694
      WBVar00914508
      WBVar01452695
      WBVar00914509
      WBVar01452696
      WBVar00914510
      WBVar01452697
      WBVar01452698
      WBVar00914511
      WBVar00914512
      WBVar01452699
      WBVar00914513
      WBVar01452701
      WBVar00572661
      WBVar01452702
      WBVar00914514
      WBVar00914515
      WBVar01452703
      WBVar00914516
      WBVar01452704
      WBVar00914517
      WBVar01452705
      WBVar01452706
      WBVar00914518
      WBVar00914519
      WBVar00914520
      WBVar00914521
      WBVar00914522
      WBVar00914523
      WBVar00914524
      WBVar01516101
      WBVar00914525
      WBVar01516102
      WBVar00914526
      WBVar00914527
      WBVar01516103
      WBVar00914528
      WBVar00914529
      WBVar00914530
      WBVar00914531
      WBVar01923529
      WBVar01923530
      WBVar00914532
      WBVar01923531
      WBVar00914533
      WBVar00914534
      WBVar01923532
      WBVar00914535
      WBVar00914536
      WBVar00914537
      WBVar00914538
      WBVar00914539
      WBVar00914540
      WBVar00914541
      WBVar00914542
      WBVar00914543
      WBVar00914544
      WBVar02146622
      WBVar00914545
      WBVar00914546
      WBVar00914547
      WBVar00914548
      WBVar00914549
      WBVar00143348
      WBVar01581173
      WBVar00914550
      WBVar00598746
      WBVar00914551
      WBVar00914552
      WBVar00914553
      WBVar00914554
      WBVar00914555
      WBVar00914556
      WBVar01500245
      WBVar00914557
      WBVar00426447
      WBVar00914558
      WBVar00914559
      WBVar00426448
      WBVar00426449
      WBVar00914560
      WBVar00914561
      WBVar00426450
      WBVar00914562
      WBVar00426451
    Legacy_information: e625 : irregular loopy movement both forward and reverse; active; thin; sometimes protrusive vulva. Slight movement abnormality in e625/+. ES2 ME2 NA1.
      [C.elegansII] e625 : irregular loopy movement both forward and reverse; active; thin; sometimes protrusive vulva. Slight movement abnormality in e625/+. ES2 ME2 NA1. [Brenner 1974]
    Strain: WBStrain00035028
      WBStrain00035029
      WBStrain00035482
      WBStrain00040855
      WBStrain00040862
      WBStrain00040863
      WBStrain00040864
      WBStrain00040865
      WBStrain00006352
    Component_of_genotype: WBGenotype00000089
      WBGenotype00000090
      WBGenotype00000091
    RNASeq_FPKM (74)
    GO_annotation (18)
    Ortholog (51)
    Paralog: WBGene00003558 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00000367 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00001187 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006742 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00008911 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: unc-77 encodes, along with nca-2, one of two C. elegans alpha-1-like subunits of a voltage-insensitive cation leak channel related to Drosophila narrow abdomen and the vertebrate Vgcnl1/NALCN proteins; unc-77 functions redundantly with nca-2 to transmit depolarization signals from neuronal cell bodies to axons, thus regulating presynaptic activation; unc-77 and nca-2 are also required for normal locomotion and the response to specific volatile anesthetics; in regulating synaptic activity, unc-77 appears to function in the same pathway as unc-79 and unc-80, which encode novel conserved proteins that reciprocally regulate UNC-77 expression; co-expression of UNC-77 and UNC-80 in HEK293T cells results in increased UNC-77 channel activity, in a manner consistent with UNC-77 and UNC-80 functioning as an ion leak channel; an unc-77::gfp reporter fusion is expressed in many sensory and all motoneurons; in the dorsal and ventral nerve cords, UNC-77 localizes to specific axonal regions, but not to synapses. Paper_evidence: WBPaper00030757
            WBPaper00031000
            WBPaper00031592
          Curator_confirmed: WBPerson1843
          Date_last_updated: 22 Jun 2010 00:00:00
      Automated_description: Enables monoatomic cation channel activity. Involved in positive regulation of GABAergic synaptic transmission; positive regulation of cholinergic synaptic transmission; and positive regulation of locomotion. Located in axon. Expressed in cholinergic neurons; nerve ring; pharyngeal neurons; and tail ganglion. Used to study congenital limbs-face contractures-hypotonia-developmental delay syndrome. Human ortholog(s) of this gene implicated in congenital limbs-face contractures-hypotonia-developmental delay syndrome. Is an ortholog of human NALCN (sodium leak channel, non-selective). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:0081048 Homo sapiens Paper_evidence: WBPaper00046648
          Curator_confirmed: WBPerson324
          Date_last_updated: 09 Feb 2022 00:00:00
    Potential_model: EFO:MONDO:0014176 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:19082)
      DOID:0081048 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:19082)
  Models_disease_asserted: WBDOannot00001101
    WBDOannot00001105
  Molecular_info: Corresponding_CDS (16)
    Corresponding_CDS_history: C11D2.6a:wp239
      C11D2.6b:wp239
      C11D2.6c:wp239
    Corresponding_transcript (16)
    Other_sequence (15)
    Associated_feature: WBsf651837
      WBsf996705
      WBsf996706
      WBsf996707
      WBsf996708
      WBsf996709
      WBsf1017492
      WBsf1017493
      WBsf230141
      WBsf230142
  Experimental_info: RNAi_result (15)
    Expr_pattern: Chronogram197
      Expr4860
      Expr5240
      Expr8058
      Expr8060
      Expr8194
      Expr8324
      Expr1144413
      Expr2017906
      Expr2036042
    Drives_construct (12)
    Construct_product: WBCnstr00017151
      WBCnstr00021676
      WBCnstr00021677
      WBCnstr00021678
      WBCnstr00021679
      WBCnstr00021680
      WBCnstr00021681
      WBCnstr00037886
    Antibody: WBAntibody00001260
      WBAntibody00001384
    Microarray_results (48)
    Expression_cluster (190)
    Interaction (21)
  Map_info (3)
  Reference (42)
  Method: Gene