WormBase Tree Display for Gene: WBGene00006781
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WBGene00006781 | SMap | S_parent | Sequence | F30H5 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | unc-45 | Person_evidence | WBPerson261 | |||||
Sequence_name | F30H5.1 | ||||||||
Molecular_name | F30H5.1 | ||||||||
F30H5.1.1 | |||||||||
CE01925 | |||||||||
Other_name | CELE_F30H5.1 | Accession_evidence | NDB | BX284603 | |||||
Public_name | unc-45 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | unc | ||||||||
Reference_allele | WBVar00143087 | ||||||||
Allele (249) | |||||||||
Legacy_information | e286ts : at 25x limp paralysed Egl : muscle ultrastructure defective few thick filaments; males move better; at 20x slow at 15x wildtype. ES3 (adult 25x) ME0. NA > 5 (m94ts r450ts : all alleles are temperature sensitive but some have stronger 20x phenotype than e286). Null phenotype probably lethal. | ||||||||
[C.elegansII] e286ts : at 25C limp paralysed Egl; muscle ultrastructure defective, few thick filaments; males move better; at 20C slow, at 15C wildtype. ES3 (adult 25C) ME0. OA>5: m94ts, r450ts, su2002 (some ts alleles have stronger 20C phenotype than e286). Also lethal Pat alleles: st601, st603,(limited development beyond two-fold,no pharyngeal pumping, failure to assemble thick filaments), st604 (weaker allele, some maternal rescue), wc2, wc4, wc5. [Venolia and Waterston 1990; LV] | |||||||||
Strain (19) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (25) | |||||||||
Ortholog (43) | |||||||||
Paralog (5) | |||||||||
Structured_description | Concise_description | unc-45 encodes a conserved, muscle-specific protein that contains an N-terminal TRP (tetratricopeptide repeat) and a C-terminal UCS (UNC-45-CRO1-She4p) domain; during body wall muscle development, UNC-45 activity is essential for proper thick filament formation and sarcomere organization; in addition, maternally provided UNC-45 is required for embryonic polarity, cytokinesis, and germline cellularization; in regulating muscle development, UNC-45 acts, as both a chaperone and an HSP-90 cochaperone, to control type II myosin folding and assembly into thick filaments; in regulating polarity, cytokinesis and germline cellularization, maternal UNC-45 is essential for normal functioning of the NMY-2 non-muscle myosin II; UNC-45 can physically interact with myosin, Hsp90, and NMY-2; UNC-45 levels, and hence activity, are controlled by a novel E3/E4-multiubiquitylation complex containing CDC-48, UFD-2, and CHN-1; in muscle cells, UNC-45 colocalizes with myosin heavy chain B to thick filaments; in the embryo, UNC-45 colocalizes with NMY-2 at the cell cortex and the cleavage furrow; UNC-45 localization at the cell cortex and cleavage furrow is dependent upon NMY-2. | Paper_evidence | WBPaper00000128 | |||||
WBPaper00003423 | |||||||||
WBPaper00003891 | |||||||||
WBPaper00005090 | |||||||||
WBPaper00024873 | |||||||||
WBPaper00029296 | |||||||||
WBPaper00031424 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 26 Jun 2008 00:00:00 | ||||||||
Automated_description | Enables identical protein binding activity; protein folding chaperone; and ubiquitin protein ligase binding activity. Involved in several processes, including chaperone-mediated protein folding; egg-laying behavior; and sarcomere organization. Located in cell cortex and cleavage furrow. Expressed in body wall musculature and non-striated muscle. Human ortholog(s) of this gene implicated in cataract 43 and myofibrillar myopathy 11. Is an ortholog of human UNC45B (unc-45 myosin chaperone B). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0110259 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14304) | ||||
DOID:0081338 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14304) | ||||||
Molecular_info | Corresponding_CDS | F30H5.1 | |||||||
Corresponding_transcript | F30H5.1.1 | ||||||||
Other_sequence (58) | |||||||||
Associated_feature | WBsf644916 | ||||||||
WBsf717851 | |||||||||
WBsf991073 | |||||||||
WBsf991074 | |||||||||
WBsf1014077 | |||||||||
WBsf1014078 | |||||||||
WBsf1014079 | |||||||||
WBsf1014080 | |||||||||
WBsf224370 | |||||||||
WBsf224371 | |||||||||
Experimental_info | RNAi_result (34) | ||||||||
Expr_pattern | Expr1270 | ||||||||
Expr2733 | |||||||||
Expr2734 | |||||||||
Expr3114 | |||||||||
Expr1013782 | |||||||||
Expr1032853 | |||||||||
Expr1149872 | |||||||||
Expr2017878 | |||||||||
Expr2036014 | |||||||||
Drives_construct | WBCnstr00004615 | ||||||||
WBCnstr00004616 | |||||||||
WBCnstr00006321 | |||||||||
WBCnstr00010185 | |||||||||
WBCnstr00010924 | |||||||||
WBCnstr00034156 | |||||||||
Construct_product (27) | |||||||||
Antibody | WBAntibody00002802 | ||||||||
WBAntibody00002810 | |||||||||
Microarray_results (23) | |||||||||
Expression_cluster (115) | |||||||||
Interaction | WBInteraction000000062 | ||||||||
WBInteraction000001284 | |||||||||
WBInteraction000001285 | |||||||||
WBInteraction000004637 | |||||||||
WBInteraction000004638 | |||||||||
WBInteraction000005414 | |||||||||
WBInteraction000005415 | |||||||||
WBInteraction000009608 | |||||||||
WBInteraction000029654 | |||||||||
WBInteraction000050761 | |||||||||
WBInteraction000050762 | |||||||||
WBInteraction000126307 | |||||||||
WBInteraction000146280 | |||||||||
WBInteraction000146281 | |||||||||
WBInteraction000166403 | |||||||||
WBInteraction000166410 | |||||||||
WBInteraction000502846 | |||||||||
WBInteraction000502847 | |||||||||
WBInteraction000502848 | |||||||||
WBInteraction000502849 | |||||||||
WBInteraction000503440 | |||||||||
WBInteraction000503441 | |||||||||
WBInteraction000503766 | |||||||||
WBInteraction000534891 | |||||||||
WBInteraction000534892 | |||||||||
WBInteraction000534893 | |||||||||
WBInteraction000534894 | |||||||||
WBInteraction000534895 | |||||||||
WBInteraction000534896 | |||||||||
WBInteraction000534897 | |||||||||
WBInteraction000536825 | |||||||||
WBInteraction000540498 | |||||||||
WBInteraction000540636 | |||||||||
WBInteraction000540640 | |||||||||
WBInteraction000540957 | |||||||||
WBInteraction000541042 | |||||||||
WBInteraction000541085 | |||||||||
WBInteraction000542079 | |||||||||
WBInteraction000542137 | |||||||||
WBInteraction000542141 | |||||||||
WBInteraction000542351 | |||||||||
WBInteraction000542538 | |||||||||
WBInteraction000542721 | |||||||||
WBInteraction000551332 | |||||||||
WBInteraction000555304 | |||||||||
WBInteraction000555983 | |||||||||
WBInteraction000556349 | |||||||||
WBInteraction000556367 | |||||||||
WBInteraction000560388 | |||||||||
WBInteraction000560445 | |||||||||
WBInteraction000562950 | |||||||||
WBInteraction000563585 | |||||||||
WBInteraction000565221 | |||||||||
WBInteraction000565222 | |||||||||
WBInteraction000565223 | |||||||||
WBInteraction000565224 | |||||||||
WBInteraction000565225 | |||||||||
WBInteraction000565245 | |||||||||
WBInteraction000569806 | |||||||||
WBInteraction000574774 | |||||||||
WBInteraction000579642 | |||||||||
WBInteraction000583920 | |||||||||
WBInteraction000584208 | |||||||||
WBInteraction000586692 | |||||||||
Map_info | Map | III | Position | -26.8249 | Error | 0.015687 | |||
Well_ordered | |||||||||
Positive | Positive_clone | F30H5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
W10B10 | |||||||||
Mapping_data | 2_point (12) | ||||||||
Multi_point (41) | |||||||||
Pos_neg_data | 5743 | ||||||||
Landmark_gene | |||||||||
Reference (117) | |||||||||
Method | Gene |