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WormBase Tree Display for Gene: WBGene00006781

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Name Class

WBGene00006781SMapS_parentSequenceF30H5
IdentityVersion1
NameCGC_nameunc-45Person_evidenceWBPerson261
Sequence_nameF30H5.1
Molecular_nameF30H5.1
F30H5.1.1
CE01925
Other_nameCELE_F30H5.1Accession_evidenceNDBBX284603
Public_nameunc-45
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:42WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Reference_alleleWBVar00143087
Allele (249)
Legacy_informatione286ts : at 25x limp paralysed Egl : muscle ultrastructure defective few thick filaments; males move better; at 20x slow at 15x wildtype. ES3 (adult 25x) ME0. NA > 5 (m94ts r450ts : all alleles are temperature sensitive but some have stronger 20x phenotype than e286). Null phenotype probably lethal.
[C.elegansII] e286ts : at 25C limp paralysed Egl; muscle ultrastructure defective, few thick filaments; males move better; at 20C slow, at 15C wildtype. ES3 (adult 25C) ME0. OA>5: m94ts, r450ts, su2002 (some ts alleles have stronger 20C phenotype than e286). Also lethal Pat alleles: st601, st603,(limited development beyond two-fold,no pharyngeal pumping, failure to assemble thick filaments), st604 (weaker allele, some maternal rescue), wc2, wc4, wc5. [Venolia and Waterston 1990; LV]
Strain (19)
RNASeq_FPKM (74)
GO_annotation (25)
OrthologWBGene00064906Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00035594Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00153346Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00114420Pristionchus pacificusFrom_analysisOMA
Inparanoid_8
WormBase-Compara
WBGene00138144Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00223974Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g5876Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g2483Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g99Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g12969Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g10604Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP29.g22485Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g21091Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g12086Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g3758Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g7014Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g6814Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00691.g13480Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-unc-45Caenorhabditis nigoniFrom_analysisWormBase-Compara
Cnig_chr_III.g8541Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold630.g16717Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00890.g16508Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_18598Caenorhabditis latensFrom_analysisWormBase-Compara
FL83_21811Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_011838Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g14343Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g8350Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_30336220Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrIII_pilon.g6765Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00240035Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00276807Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00255836Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00289133Trichuris murisFrom_analysisWormBase-Compara
SGD:S000005561Saccharomyces cerevisiaeFrom_analysisHieranoid
OrthoFinder
Panther
FB:FBgn0010812Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-020919-3Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-050417-158Danio rerioFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:30594Homo sapiensFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:14304Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:2142246Mus musculusFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:2443377Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1305666Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1305357Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ParalogWBGene00000500Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00015916Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00016375Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00019893Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00019983Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionunc-45 encodes a conserved, muscle-specific protein that contains an N-terminal TRP (tetratricopeptide repeat) and a C-terminal UCS (UNC-45-CRO1-She4p) domain; during body wall muscle development, UNC-45 activity is essential for proper thick filament formation and sarcomere organization; in addition, maternally provided UNC-45 is required for embryonic polarity, cytokinesis, and germline cellularization; in regulating muscle development, UNC-45 acts, as both a chaperone and an HSP-90 cochaperone, to control type II myosin folding and assembly into thick filaments; in regulating polarity, cytokinesis and germline cellularization, maternal UNC-45 is essential for normal functioning of the NMY-2 non-muscle myosin II; UNC-45 can physically interact with myosin, Hsp90, and NMY-2; UNC-45 levels, and hence activity, are controlled by a novel E3/E4-multiubiquitylation complex containing CDC-48, UFD-2, and CHN-1; in muscle cells, UNC-45 colocalizes with myosin heavy chain B to thick filaments; in the embryo, UNC-45 colocalizes with NMY-2 at the cell cortex and the cleavage furrow; UNC-45 localization at the cell cortex and cleavage furrow is dependent upon NMY-2.Paper_evidenceWBPaper00000128
WBPaper00003423
WBPaper00003891
WBPaper00005090
WBPaper00024873
WBPaper00029296
WBPaper00031424
Curator_confirmedWBPerson1843
Date_last_updated26 Jun 2008 00:00:00
Automated_descriptionEnables identical protein binding activity; protein folding chaperone; and ubiquitin protein ligase binding activity. Involved in several processes, including chaperone-mediated protein folding; egg-laying behavior; and sarcomere organization. Located in cell cortex and cleavage furrow. Expressed in body wall musculature and non-striated muscle. Human ortholog(s) of this gene implicated in cataract 43 and myofibrillar myopathy 11. Is an ortholog of human UNC45B (unc-45 myosin chaperone B).Paper_evidenceWBPaper00065943
Curator_confirmed (2)
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0110259Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:14304)
DOID:0081338Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:14304)
Molecular_infoCorresponding_CDSF30H5.1
Corresponding_transcriptF30H5.1.1
Other_sequence (58)
Associated_featureWBsf644916
WBsf717851
WBsf991073
WBsf991074
WBsf1014077
WBsf1014078
WBsf1014079
WBsf1014080
WBsf224370
WBsf224371
Experimental_infoRNAi_result (34)
Expr_patternExpr1270
Expr2733
Expr2734
Expr3114
Expr1013782
Expr1032853
Expr1149872
Expr2017878
Expr2036014
Drives_constructWBCnstr00004615
WBCnstr00004616
WBCnstr00006321
WBCnstr00010185
WBCnstr00010924
WBCnstr00034156
Construct_product (27)
AntibodyWBAntibody00002802
WBAntibody00002810
Microarray_results (23)
Expression_cluster (115)
Interaction (64)
Map_infoMapIIIPosition-26.8249Error0.015687
Well_ordered
PositivePositive_cloneF30H5Inferred_automaticallyFrom sequence, transcript, pseudogene data
W10B10
Mapping_data2_point (12)
Multi_point (41)
Pos_neg_data5743
Landmark_gene
Reference (117)
MethodGene