WormBase Tree Display for Gene: WBGene00002232

WBGene00002232 SMap: S_parent: Sequence: F11A6
  Identity: Version: 1
    Name: CGC_name: kpc-1 Person_evidence: WBPerson533
      Sequence_name: F11A6.1
      Molecular_name: F11A6.1a
        F11A6.1a.1
        CE17653
        F11A6.1a.2
        F11A6.1b
      Other_name: CELE_F11A6.1 Accession_evidence: NDB BX284601
      Public_name: kpc-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:27 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: kpc
    Allele (115)
    Strain: WBStrain00035504
    RNASeq_FPKM (74)
    GO_annotation: 00030703
      00030704
      00030705
      00030706
      00030707
      00030708
      00030709
      00030710
      00030711
      00030712
      00030713
      00030714
      00030715
      00030716
      00030717
      00030718
      00030719
      00030720
      00030721
      00030722
      00030723
      00030724
      00030725
      00030726
      00030727
      00030728
      00030729
      00030730
      00030731
      00030732
      00030733
      00030734
      00030735
      00030736
      00030737
      00030738
      00030739
      00030740
      00030741
      00030742
      00030743
      00030744
      00030745
      00030746
      00030747
      00110242
      00110243
      00110244
    Ortholog: WBGene00071303 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00035938 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00154502 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00098806 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00121280 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00155888 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00123364 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00060890 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00223554 Brugia malayi From_analysis: WormBase-Compara
      CSP21.g3740 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g16107 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g3949 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g4134 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g12261 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g10900 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g21076 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g23426 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g7756 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g1818 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00204.g6942 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-kpc-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g19702 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01990.g24253 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_23292 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_003239 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12116 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g2163 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10045800 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g2322 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00237591 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00261375 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00286114 Trichuris muris From_analysis: WormBase-Compara
      WBGene00291051 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000005182 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0004509 Drosophila melanogaster From_analysis: OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040901-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-040901-2 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:8568 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:8569 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      HGNC:8747 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      HGNC:8746 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      MGI:97513 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:97514 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      MGI:97515 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      MGI:102897 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      RGD:3246 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      RGD:3274 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:620326 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      RGD:620325 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
            SonicParanoid
    Paralog: WBGene00000088 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000254 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001172 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00017686 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: kpc-1 encodes two isoforms of a Kex2/subtilisin-like proprotein convertase that is a member of the subtilase family of calcium-dependent serine endoproteinases that includes mammalian furin (OMIM:136950) and Saccharomyces cerevisiae Kex2p; KPC-1 is required for normal growth and locomotion and is likely responsible for the processing of transforming growth factor (TGF) beta proproteins encoded by daf-7, dbl-1, and unc-129. Paper_evidence: WBPaper00004142
            WBPaper00018607
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables serine-type endopeptidase activity and signaling receptor binding activity. Involved in several processes, including neuron development; positive regulation of developmental process; and protein processing. Located in neuronal cell body. Expressed in several structures, including PVD; epithelial cell; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in arteriosclerosis; colon adenocarcinoma; and colorectal adenocarcinoma. Is an ortholog of human FURIN (furin, paired basic amino acid cleaving enzyme). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:234 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8747)
      DOID:2349 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8568)
      DOID:0050861 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8746)
  Molecular_info: Corresponding_CDS: F11A6.1a
    Corresponding_CDS_history: F11A6.1b:wp245
    Corresponding_transcript: F11A6.1b
      F11A6.1a.1
      F11A6.1a.2
    Other_sequence (36)
    Associated_feature (22)
  Experimental_info: RNAi_result: WBRNAi00116836 Inferred_automatically: RNAi_primary
      WBRNAi00003363 Inferred_automatically: RNAi_primary
      WBRNAi00089035 Inferred_automatically: RNAi_primary
      WBRNAi00106792 Inferred_automatically: RNAi_primary
      WBRNAi00044358 Inferred_automatically: RNAi_primary
      WBRNAi00027714 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00018109
      WBCnstr00018110
      WBCnstr00020063
    Construct_product: WBCnstr00018110
      WBCnstr00018228
      WBCnstr00019277
      WBCnstr00043014
    Microarray_results (39)
    Expression_cluster (198)
    Interaction (29)
  Map_info: Map: I Position: 9.53611 Error: 0.019245
    Positive: Positive_clone: F11A6 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4460
        4467
    Pseudo_map_position
  Reference (28)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene