WormBase Tree Display for Gene: WBGene00002232

WBGene00002232 SMap: S_parent: Sequence: F11A6
  Identity: Version: 1
    Name: CGC_name: kpc-1 Person_evidence: WBPerson533
      Sequence_name: F11A6.1
      Molecular_name: F11A6.1a
        F11A6.1a.1
        CE17653
        F11A6.1a.2
        F11A6.1b
      Other_name: CELE_F11A6.1 Accession_evidence: NDB BX284601
      Public_name: kpc-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:27 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: kpc
    Allele (115)
    Strain: WBStrain00035504
    RNASeq_FPKM (74)
    GO_annotation (48)
    Ortholog: WBGene00071303 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00035938 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00154502 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00098806 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00121280 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00155888 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00123364 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00060890 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00223554 Brugia malayi From_analysis: WormBase-Compara
      CSP21.g3740 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g16107 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g3949 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g4134 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g12261 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g10900 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g21076 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g23426 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g7756 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g1818 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00204.g6942 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-kpc-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g19702 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01990.g24253 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_23292 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_003239 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12116 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g2163 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10045800 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g2322 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00237591 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00261375 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00286114 Trichuris muris From_analysis: WormBase-Compara
      WBGene00291051 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000005182 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0004509 Drosophila melanogaster From_analysis: OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040901-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-040901-2 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:8568 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:8569 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      HGNC:8747 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      HGNC:8746 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      MGI:97513 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:97514 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      MGI:97515 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      MGI:102897 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      RGD:3246 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      RGD:3274 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:620326 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      RGD:620325 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
            SonicParanoid
    Paralog: WBGene00000088 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000254 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001172 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00017686 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: kpc-1 encodes two isoforms of a Kex2/subtilisin-like proprotein convertase that is a member of the subtilase family of calcium-dependent serine endoproteinases that includes mammalian furin (OMIM:136950) and Saccharomyces cerevisiae Kex2p; KPC-1 is required for normal growth and locomotion and is likely responsible for the processing of transforming growth factor (TGF) beta proproteins encoded by daf-7, dbl-1, and unc-129. Paper_evidence: WBPaper00004142
            WBPaper00018607
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables serine-type endopeptidase activity and signaling receptor binding activity. Involved in several processes, including neuron development; positive regulation of developmental process; and protein processing. Located in neuronal cell body. Expressed in several structures, including PVD; epithelial cell; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in arteriosclerosis; colon adenocarcinoma; and colorectal adenocarcinoma. Is an ortholog of human FURIN (furin, paired basic amino acid cleaving enzyme). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:234 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8747)
      DOID:2349 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8568)
      DOID:0050861 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8746)
  Molecular_info: Corresponding_CDS: F11A6.1a
    Corresponding_CDS_history: F11A6.1b:wp245
    Corresponding_transcript: F11A6.1b
      F11A6.1a.1
      F11A6.1a.2
    Other_sequence (36)
    Associated_feature (22)
  Experimental_info: RNAi_result: WBRNAi00116836 Inferred_automatically: RNAi_primary
      WBRNAi00003363 Inferred_automatically: RNAi_primary
      WBRNAi00089035 Inferred_automatically: RNAi_primary
      WBRNAi00106792 Inferred_automatically: RNAi_primary
      WBRNAi00044358 Inferred_automatically: RNAi_primary
      WBRNAi00027714 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00018109
      WBCnstr00018110
      WBCnstr00020063
    Construct_product: WBCnstr00018110
      WBCnstr00018228
      WBCnstr00019277
      WBCnstr00043014
    Microarray_results (39)
    Expression_cluster (198)
    Interaction (29)
  Map_info: Map: I Position: 9.53611 Error: 0.019245
    Positive: Positive_clone: F11A6 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4460
        4467
    Pseudo_map_position
  Reference (28)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene