WormBase Tree Display for Gene: WBGene00004729

WBGene00004729 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 2
    Name: CGC_name: sax-3 Person_evidence: WBPerson42
      Sequence_name: ZK377.2
      Molecular_name: ZK377.2a
        ZK377.2a.1
        CE25688
        ZK377.2b
        CE31267
        ZK377.2b.1
      Other_name: CELE_ZK377.2 Accession_evidence: NDB BX284606
      Public_name: sax-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 02 Mar 2018 11:09:16 WBPerson4025 Event: Split_into: WBGene00303098
      Split_into: WBGene00303098
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sax
    Allele: WBVar00088418 Inferred_automatically: From strain object: CX3171
      WBVar00088406 Inferred_automatically: From strain object: CX3198
          From strain object: IC361
          From strain object: IC459
          From strain object: IC464
          From strain object: IC476
          From strain object: IC699
      WBVar00499132
      WBVar01133888
      WBVar00499133
      WBVar01133889
      WBVar01133890
      WBVar00499134
      WBVar01133891
      WBVar00499135
      WBVar00499136
      WBVar01825047
      WBVar01133892
      WBVar00499137
      WBVar01133893
      WBVar00499138
      WBVar01133894
      WBVar00499139
      WBVar01133895
      WBVar01133896
      WBVar00499140
      WBVar01133897
      WBVar00499141
      WBVar00499142
      WBVar02056360
      WBVar01133898
      WBVar01133899
      WBVar00499143
      WBVar00077121
      WBVar00499144
      WBVar01133900
      WBVar00077122
      WBVar00499145
      WBVar01133901
      WBVar00077123
      WBVar00088416
      WBVar01133902
      WBVar00499146
      WBVar00499147
      WBVar01133903
      WBVar00088420
      WBVar01133904
      WBVar01133905
      WBVar01133906
      WBVar01133907
      WBVar01133908
      WBVar01133909
      WBVar01133910
      WBVar01133911
      WBVar01133912
      WBVar01133913
      WBVar01133914
      WBVar01133915
      WBVar01133916
      WBVar01133917
      WBVar01133918
      WBVar01133919
      WBVar01133920
      WBVar01133921
      WBVar01133922
      WBVar01133923
      WBVar01133924
      WBVar01133925
      WBVar01133926
      WBVar01819554
      WBVar01133927
      WBVar01133928
      WBVar01133929
      WBVar01133930
      WBVar01133931
      WBVar01133932
      WBVar01945140
      WBVar01133933
      WBVar01133934
      WBVar01133935
      WBVar01133936
      WBVar01133937
      WBVar01133938
      WBVar02026922
      WBVar02026923
      WBVar01133939
      WBVar02111081
      WBVar01133940
      WBVar01133941
      WBVar01133942
      WBVar02153697
      WBVar01133943
      WBVar01133944
      WBVar01133945
      WBVar01133946
      WBVar01133947
      WBVar01133948
      WBVar01486695
      WBVar02044495
      WBVar01133949
      WBVar02044496
      WBVar01133950
      WBVar01133951
      WBVar01133952
      WBVar01133953
      WBVar01133954
      WBVar01133955
      WBVar01133956
      WBVar01133957
      WBVar01133958
      WBVar01980154
      WBVar01133959
      WBVar01133960
      WBVar01133961
      WBVar01133962
      WBVar01133963
      WBVar01133964
      WBVar01133965
      WBVar01133966
      WBVar01133967
      WBVar01133968
      WBVar01133969
      WBVar01133970
      WBVar01133971
      WBVar01133972
      WBVar01133973
      WBVar01133974
      WBVar01133975
      WBVar01133976
      WBVar01133977
      WBVar01133978
      WBVar01133979
      WBVar01133980
      WBVar01133981
      WBVar01496664
      WBVar01133982
      WBVar01133983
      WBVar02152624
      WBVar01133984
      WBVar01133985
      WBVar01133986
      WBVar01601369
      WBVar01601370
      WBVar01601371
      WBVar01998626
      WBVar01499636
      WBVar01661389
      WBVar01468283
      WBVar01468284
      WBVar01468285
      WBVar01468286
      WBVar01468287
      WBVar02139019
      WBVar02139020
      WBVar00499117
      WBVar00499118
      WBVar00499119
      WBVar00499120
      WBVar00499121
      WBVar00499122
      WBVar00499123
      WBVar00499124
      WBVar00499125
      WBVar02148417
      WBVar00499126
      WBVar00499127
      WBVar02048722
      WBVar01133884
      WBVar00499128
      WBVar01133885
      WBVar00499129
      WBVar00499130
      WBVar01133886
      WBVar01500067
      WBVar01133887
      WBVar00499131
    Legacy_information: [Zallen JA] ky123 recessive, homozygotes exhibit aberrant anterior position of nerve ring, many ring axons misrouted, ventral nerve cord neurons often misrouted, cross midline. Encodes three isoforms, longest 1273 aa with 5 Ig repeats, 3 FNIII repeats, TM domain, large cytoplasmic domain. ky123 deletes signal sequence and first exon, probable null. Predicted gene ZK377.3 + ZK377.2
    Strain (11)
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (50)
    Paralog (22)
    Structured_description: Concise_description: sax-3 encodes, by alternative splicing, two isoforms of an ortholog of Drosophila ROUNDABOUT, ROBO3, and LEAK, and of human ROBO1, ROBO2 (OMIM:602431, mutated in vesicoureteral reflux), and ROBO3 (OMIM:608630, mutated in horizontal gaze palsy with progressive scoliosis); in larval hermaphrodites, SAX-3 is required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance. Paper_evidence: WBPaper00003665
            WBPaper00004362
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 24 Jan 2008 00:00:00
      Automated_description: Enables axon guidance receptor activity. Involved in generation of neurons and regulation of sensory neuron axon guidance. Located in plasma membrane. Expressed in several structures, including QR.a; QR.p; body wall musculature; neuroblasts; and neurons. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital nystagmus; hematologic cancer (multiple); and myositis (multiple). Is an ortholog of human ROBO1 (roundabout guidance receptor 1); ROBO2 (roundabout guidance receptor 2); and ROBO3 (roundabout guidance receptor 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (11)
  Molecular_info: Corresponding_CDS: ZK377.2a
      ZK377.2b
    Corresponding_CDS_history: ZK377.2c:wp264
    Corresponding_transcript: ZK377.2a.1
      ZK377.2b.1
    Other_sequence (32)
    Associated_feature (39)
  Experimental_info: RNAi_result: WBRNAi00086088 Inferred_automatically: RNAi_primary
      WBRNAi00086133 Inferred_automatically: RNAi_primary
      WBRNAi00009468 Inferred_automatically: RNAi_primary
      WBRNAi00009467 Inferred_automatically: RNAi_primary
      WBRNAi00067130 Inferred_automatically: RNAi_primary
      WBRNAi00059385 Inferred_automatically: RNAi_primary
    Expr_pattern (17)
    Drives_construct: WBCnstr00001914
      WBCnstr00003185
      WBCnstr00006455
      WBCnstr00009445
      WBCnstr00012503
      WBCnstr00016209
      WBCnstr00035424
      WBCnstr00039977
      WBCnstr00041184
    Construct_product (15)
    Microarray_results (28)
    Expression_cluster (134)
    Interaction: WBInteraction000001176
      WBInteraction000001444
      WBInteraction000001445
      WBInteraction000001854
      WBInteraction000001856
      WBInteraction000002382
      WBInteraction000002383
      WBInteraction000002430
      WBInteraction000003040
      WBInteraction000005252
      WBInteraction000005444
      WBInteraction000006584
      WBInteraction000008783
      WBInteraction000009325
      WBInteraction000009345
      WBInteraction000009360
      WBInteraction000009499
      WBInteraction000028579
      WBInteraction000029295
      WBInteraction000029405
      WBInteraction000029455
      WBInteraction000029621
      WBInteraction000030129
      WBInteraction000032535
      WBInteraction000032685
      WBInteraction000032686
      WBInteraction000033075
      WBInteraction000033156
      WBInteraction000033168
      WBInteraction000033329
      WBInteraction000033339
      WBInteraction000033343
      WBInteraction000033397
      WBInteraction000033450
      WBInteraction000033459
      WBInteraction000033463
      WBInteraction000033694
      WBInteraction000033770
      WBInteraction000033839
      WBInteraction000033914
      WBInteraction000034061
      WBInteraction000034062
      WBInteraction000034997
      WBInteraction000035150
      WBInteraction000035183
      WBInteraction000035185
      WBInteraction000035313
      WBInteraction000035741
      WBInteraction000035997
      WBInteraction000036453
      WBInteraction000036661
      WBInteraction000037260
      WBInteraction000037723
      WBInteraction000037724
      WBInteraction000038537
      WBInteraction000038659
      WBInteraction000038660
      WBInteraction000039029
      WBInteraction000039043
      WBInteraction000039069
      WBInteraction000042777
      WBInteraction000042778
      WBInteraction000042779
      WBInteraction000043442
      WBInteraction000043726
      WBInteraction000043743
      WBInteraction000043744
      WBInteraction000044410
      WBInteraction000045170
      WBInteraction000045312
      WBInteraction000046180
      WBInteraction000046843
      WBInteraction000048911
      WBInteraction000049610
      WBInteraction000049850
      WBInteraction000050197
      WBInteraction000052826
      WBInteraction000052838
      WBInteraction000113766
      WBInteraction000115676
      WBInteraction000119186
      WBInteraction000122038
      WBInteraction000126320
      WBInteraction000126718
      WBInteraction000126725
      WBInteraction000127116
      WBInteraction000133259
      WBInteraction000133307
      WBInteraction000135720
      WBInteraction000136319
      WBInteraction000137537
      WBInteraction000144307
      WBInteraction000144317
      WBInteraction000148735
      WBInteraction000153227
      WBInteraction000153229
      WBInteraction000165085
      WBInteraction000165466
      WBInteraction000165564
      WBInteraction000165748
      WBInteraction000165869
      WBInteraction000165875
      WBInteraction000166450
      WBInteraction000171197
      WBInteraction000171287
      WBInteraction000175067
      WBInteraction000178795
      WBInteraction000179852
      WBInteraction000180408
      WBInteraction000188267
      WBInteraction000192029
      WBInteraction000195349
      WBInteraction000197091
      WBInteraction000197129
      WBInteraction000198609
      WBInteraction000202364
      WBInteraction000202997
      WBInteraction000205104
      WBInteraction000209960
      WBInteraction000210549
      WBInteraction000214407
      WBInteraction000221363
      WBInteraction000222083
      WBInteraction000227006
      WBInteraction000227726
      WBInteraction000228203
      WBInteraction000231003
      WBInteraction000231471
      WBInteraction000232976
      WBInteraction000233355
      WBInteraction000251426
      WBInteraction000251443
      WBInteraction000256395
      WBInteraction000262292
      WBInteraction000269006
      WBInteraction000270676
      WBInteraction000270721
      WBInteraction000273892
      WBInteraction000274695
      WBInteraction000275210
      WBInteraction000281209
      WBInteraction000282292
      WBInteraction000283554
      WBInteraction000284733
      WBInteraction000286284
      WBInteraction000292183
      WBInteraction000292800
      WBInteraction000293826
      WBInteraction000294840
      WBInteraction000297652
      WBInteraction000299369
      WBInteraction000300191
      WBInteraction000301653
      WBInteraction000301750
      WBInteraction000303009
      WBInteraction000307500
      WBInteraction000310054
      WBInteraction000311830
      WBInteraction000319431
      WBInteraction000327933
      WBInteraction000331348
      WBInteraction000331869
      WBInteraction000333459
      WBInteraction000334224
      WBInteraction000341591
      WBInteraction000342163
      WBInteraction000345379
      WBInteraction000353079
      WBInteraction000355667
      WBInteraction000357345
      WBInteraction000364907
      WBInteraction000368756
      WBInteraction000371865
      WBInteraction000373288
      WBInteraction000373748
      WBInteraction000374212
      WBInteraction000386175
      WBInteraction000387218
      WBInteraction000390459
      WBInteraction000390805
      WBInteraction000395086
      WBInteraction000399465
      WBInteraction000400066
      WBInteraction000401280
      WBInteraction000403153
      WBInteraction000404335
      WBInteraction000407825
      WBInteraction000410990
      WBInteraction000413558
      WBInteraction000414750
      WBInteraction000414987
      WBInteraction000416042
      WBInteraction000423812
      WBInteraction000426553
      WBInteraction000428974
      WBInteraction000432111
      WBInteraction000436450
      WBInteraction000439642
      WBInteraction000441847
      WBInteraction000443269
      WBInteraction000445249
      WBInteraction000445364
      WBInteraction000446825
      WBInteraction000447885
      WBInteraction000449295
      WBInteraction000451001
      WBInteraction000451553
      WBInteraction000454167
      WBInteraction000457590
      WBInteraction000469594
      WBInteraction000470992
      WBInteraction000503563
      WBInteraction000503564
      WBInteraction000503919
      WBInteraction000503920
      WBInteraction000518369
      WBInteraction000518560
      WBInteraction000518896
      WBInteraction000518899
      WBInteraction000523853
      WBInteraction000540340
      WBInteraction000540355
      WBInteraction000540743
      WBInteraction000540744
      WBInteraction000540745
      WBInteraction000540746
      WBInteraction000551250
      WBInteraction000551251
      WBInteraction000551253
      WBInteraction000551296
      WBInteraction000551357
      WBInteraction000551358
      WBInteraction000555534
      WBInteraction000555700
      WBInteraction000556289
      WBInteraction000556752
      WBInteraction000559982
      WBInteraction000559983
      WBInteraction000559984
      WBInteraction000570692
      WBInteraction000570693
      WBInteraction000570694
      WBInteraction000570695
      WBInteraction000570696
      WBInteraction000570697
      WBInteraction000570698
      WBInteraction000570699
      WBInteraction000570700
      WBInteraction000570701
      WBInteraction000570702
      WBInteraction000570703
      WBInteraction000570704
      WBInteraction000570705
      WBInteraction000570706
      WBInteraction000570707
      WBInteraction000570708
      WBInteraction000570709
      WBInteraction000570710
      WBInteraction000570711
      WBInteraction000570712
      WBInteraction000570713
      WBInteraction000578721
    Anatomy_function: WBbtf0177
  Map_info: Map: X Position: -10.3398 Error: 0.007528
    Well_ordered
    Positive: Inside_rearr: mnDp57
      Positive_clone: R06A1
        ZK377 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3695
        3696
        4758
      Pos_neg_data: 9401
  Reference (143)
  Remark: Inferred from Zallen et al. (1998)
    2 predicted genes (see phenotype) have been merged. [sdm 05/00]
  Method: Gene