WormBase Tree Display for Gene: WBGene00004729

WBGene00004729 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 2
    Name: CGC_name: sax-3 Person_evidence: WBPerson42
      Sequence_name: ZK377.2
      Molecular_name: ZK377.2a
        ZK377.2a.1
        CE25688
        ZK377.2b
        CE31267
        ZK377.2b.1
      Other_name: CELE_ZK377.2 Accession_evidence: NDB BX284606
      Public_name: sax-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 02 Mar 2018 11:09:16 WBPerson4025 Event: Split_into: WBGene00303098
      Split_into: WBGene00303098
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sax
    Allele (171)
    Legacy_information: [Zallen JA] ky123 recessive, homozygotes exhibit aberrant anterior position of nerve ring, many ring axons misrouted, ventral nerve cord neurons often misrouted, cross midline. Encodes three isoforms, longest 1273 aa with 5 Ig repeats, 3 FNIII repeats, TM domain, large cytoplasmic domain. ky123 deletes signal sequence and first exon, probable null. Predicted gene ZK377.3 + ZK377.2
    Strain (11)
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog: WBGene00034790 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00051982 Caenorhabditis remanei From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00148619 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00128991 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00104171 Pristionchus pacificus From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00227726 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g2329 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g12021 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g3884 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g10471 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g5898 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g8996 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g5061 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g9460 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g25465 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g16259 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00024.g1476 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_09429.g22059 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-sax-3 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_X.g23886 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g18177 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00313.g9231 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_00818.g15761 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_00829 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_00830 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_024104 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12222 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12223 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g8691 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0269800 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g18763 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00242200 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00267281 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00302741 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0041097 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
      FB:FBgn0005631 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      FB:FBgn0002543 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            PhylomeDB
      ZFIN:ZDB-GENE-000209-3 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-000209-4 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-001019-1 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-1874 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:10249 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:10250 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:13433 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      MGI:1343102 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:1274781 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:1890110 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      RGD:61941 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      RGD:620167 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      RGD:1311018 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
    Paralog (22)
    Structured_description: Concise_description: sax-3 encodes, by alternative splicing, two isoforms of an ortholog of Drosophila ROUNDABOUT, ROBO3, and LEAK, and of human ROBO1, ROBO2 (OMIM:602431, mutated in vesicoureteral reflux), and ROBO3 (OMIM:608630, mutated in horizontal gaze palsy with progressive scoliosis); in larval hermaphrodites, SAX-3 is required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance. Paper_evidence: WBPaper00003665
            WBPaper00004362
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 24 Jan 2008 00:00:00
      Automated_description: Enables axon guidance receptor activity. Involved in generation of neurons and regulation of sensory neuron axon guidance. Located in plasma membrane. Expressed in several structures, including QR.a; QR.p; body wall musculature; neuroblasts; and neurons. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital nystagmus; hematologic cancer (multiple); and myositis (multiple). Is an ortholog of human ROBO1 (roundabout guidance receptor 1); ROBO2 (roundabout guidance receptor 2); and ROBO3 (roundabout guidance receptor 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (11)
  Molecular_info: Corresponding_CDS: ZK377.2a
      ZK377.2b
    Corresponding_CDS_history: ZK377.2c:wp264
    Corresponding_transcript: ZK377.2a.1
      ZK377.2b.1
    Other_sequence (32)
    Associated_feature (39)
  Experimental_info: RNAi_result: WBRNAi00086088 Inferred_automatically: RNAi_primary
      WBRNAi00086133 Inferred_automatically: RNAi_primary
      WBRNAi00009468 Inferred_automatically: RNAi_primary
      WBRNAi00009467 Inferred_automatically: RNAi_primary
      WBRNAi00067130 Inferred_automatically: RNAi_primary
      WBRNAi00059385 Inferred_automatically: RNAi_primary
    Expr_pattern (17)
    Drives_construct: WBCnstr00001914
      WBCnstr00003185
      WBCnstr00006455
      WBCnstr00009445
      WBCnstr00012503
      WBCnstr00016209
      WBCnstr00035424
      WBCnstr00039977
      WBCnstr00041184
    Construct_product (15)
    Microarray_results (28)
    Expression_cluster (134)
    Interaction (262)
    Anatomy_function: WBbtf0177
  Map_info: Map: X Position: -10.3398 Error: 0.007528
    Well_ordered
    Positive: Inside_rearr: mnDp57
      Positive_clone: R06A1
        ZK377 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3695
        3696
        4758
      Pos_neg_data: 9401
  Reference (143)
  Remark: Inferred from Zallen et al. (1998)
    2 predicted genes (see phenotype) have been merged. [sdm 05/00]
  Method: Gene