WBGene00006756 | SMap | S_parent | Sequence | ZC416 |
| Identity | Version | 1 |
| | Name | CGC_name | unc-17 | Person_evidence | WBPerson261 |
| | | Sequence_name | ZC416.8 |
| | | Molecular_name | ZC416.8a |
| | | | ZC416.8a.1 |
| | | | CE17307 |
| | | Other_name | CELE_UNC-17 | Accession_evidence | NDB | BX284604 |
| | | Public_name | unc-17 |
| | DB_info | Database | AceView | gene | 4E380 |
| | | | WormFlux | gene | WBGene00006756 |
| | | | NDB | locus_tag | CELE_UNC-17 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006756|UniProtKB=P34711 |
| | | | | family | PTHR23506 |
| | | | NCBI | gene | 24105312 |
| | | | RefSeq | protein | NM_001392284.1 |
| | | | SwissProt | UniProtAcc | P34711 |
| | | | UniProt_GCRP | UniProtAcc | P34711 |
| | | | OMIM | gene | 600336 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143061 |
| | Allele (128) |
| | Possibly_affected_by | WBVar02153018 |
| | Legacy_information | e245 : severe coiler at all stages rather small and thin; resistant to 0.1 mM lannate; suppressed by sup-1 sup-2 and sup-8; normal ChAT (choline acetyltransferase) levels. ES3 ME0. NA > 10 (most alleles resemble e245 or have slightly weaker phenotype; also anomalous alleles e113 (less uncoordinated phenotype drug sensitive loopy movement reduced ChAT levels Egl-c) and e876 (similar)). See also cha-1 : cha-1/unc-17 is probably a complex locus. |
| | | See also e245, e283, e284, e327, e334, e335, e359 |
| | | [C.elegansII] e245 : severe coiler at all stages, rather small and thin; slow irregular pumping;Ric, resistant to 0.1 mM lannate; suppressed by sup-1, sup-2 and sup-8; normal ChAT (choline acetyltransferase) levels. ES3 ME0. OA>10: ut64 (embryonic lethal, coiler, probable null), e335, e464 etc.(most viable alleles resemble e245 or slightly weaker). Also anomalous alleles: e113 (less uncoordinated phenotype, drug sensitive, loopy movement, reduced ChAT levels, Egl-c), e876 (similar), p1156 (Smg suppressible, fails to complement unc-17 and cha-1). cha-1-unc-17 is a complex locus. Cloned: 2 kb transcript, 5' UTR exon shared with cha-1; encodes predicted 532 aa vesicular acetylcholine transporter; 12 TM domains.Antibody staining punctate, most motor synapses. [Alfonso et al. 1993, 1994; AL; RM] |
| | Strain (45) |
| | RNASeq_FPKM (74) |
| | GO_annotation (35) |
| | Ortholog | WBGene00030124 | Caenorhabditis briggsae | From_analysis | Hillier-set |
| | | | | | OrthoMCL |
| | | | | | OMA |
| | | WBGene00156191 | Caenorhabditis brenneri | From_analysis | OMA |
| | | WBGene00161361 | Caenorhabditis brenneri | From_analysis | OMA |
| | | WBGene00059160 | Caenorhabditis remanei | From_analysis | OMA |
| | | FB:FBgn0270928 | Drosophila melanogaster | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | ZFIN:ZDB-GENE-040426-1410 | Danio rerio | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | ZFIN:ZDB-GENE-060929-990 | Danio rerio | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | HGNC:10936 | Homo sapiens | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | MGI:1101061 | Mus musculus | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | RGD:62072 | Rattus norvegicus | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | Paralog | WBGene00000295 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00018860 | Caenorhabditis elegans | From_analysis | Panther |
| | Structured_description | Concise_description | unc-17 encodes a synaptic vesicle acetylcholine transporter (VAChT) highly conserved amongst metazoans including Drosophila and humans (OMIM:600336); UNC-17 is essential for embryonic development, and is required in cholinergic neurons for loading acetylcholine into synaptic vesicles to which UNC-17 is localized; UNC-17 expression may be regulated indirectly by the UNC-4/UNC-37 transcriptional repressor complex, as UNC-17 expression is greatly reduced in unc-4 and unc-37 mutant backgrounds. | Paper_evidence | WBPaper00001770 |
| | | | | | WBPaper00004594 |
| | | | | | WBPaper00004985 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Enables acetylcholine transmembrane transporter activity. Involved in several processes, including cholinergic synaptic transmission; nematode larval development; and regulation of pharyngeal pumping. Located in neuron projection; organelle membrane; and synapse. Expressed in neurons; pm2; somatic nervous system; and in male. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and congenital myasthenic syndrome 21. Is an ortholog of human SLC18A3 (solute carrier family 18 member A3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10936) |
| | | DOID:0110672 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10936) |
| | | DOID:12858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10936) |
| Molecular_info | Corresponding_CDS | ZC416.8a |
| | Corresponding_transcript | ZC416.8a.1 |
| | Other_sequence (32) |
| | Associated_feature | WBsf995999 |
| | | WBsf996000 |
| | | WBsf996001 |
| | | WBsf996002 |
| | | WBsf1017092 |
| | | WBsf1017093 |
| | | WBsf1017094 |
| | | WBsf1017095 |
| | | WBsf229908 |
| | | WBsf229909 |
| Experimental_info | RNAi_result (21) |
| | Expr_pattern (16) |
| | Drives_construct (93) |
| | Construct_product (15) |
| | Antibody | WBAntibody00000071 |
| | | WBAntibody00000365 |
| | | WBAntibody00001234 |
| | | WBAntibody00001338 |
| | | WBAntibody00001339 |
| | | WBAntibody00001340 |
| | | WBAntibody00001723 |
| | | WBAntibody00001870 |
| | Microarray_results (17) |
| | Expression_cluster | WBPaper00024970:GABAergic_neuron_specific |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032425:down_in_alg-1 |
| | | WBPaper00032425:up_in_lin-35 |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044656:tatn-1(qd182)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045486:starvation_downregulated |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055648:male-tail_expressed |
| | | WBPaper00055648:nerve-ring_expressed |
| | | WBPaper00055827:pfd-6(gk493446)_downregulated |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00056073:NHR-86_interacting_promoter |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059334:sacy-1(depletion)_regulated |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00061340:AIA |
| | | WBPaper00061340:AIY |
| | | WBPaper00061340:AVA |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVD |
| | | WBPaper00061340:AVE |
| | | WBPaper00061340:AVG |
| | | WBPaper00061340:AVJ |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:PVP |
| | | WBPaper00061340:PVT |
| | | WBPaper00061340:RIA |
| | | WBPaper00061340:RIH |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:SIA |
| | | WBPaper00061340:SMD |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061651:AS_enriched |
| | | WBPaper00061651:DA9_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB01_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:IL2_LR_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061651:VB_enriched |
| | | WBPaper00061651:VC_4_5_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065841:6_0 |
| | | WBPaper00065841:6_1 |
| | | WBPaper00065841:6_2 |
| | | WBPaper00065841:6_3 |
| | | WBPaper00065841:14_0 |
| | | WBPaper00065841:14_1 |
| | | WBPaper00065841:14_2 |
| | | WBPaper00065841:19_0 |
| | | WBPaper00065841:22_0 |
| | | WBPaper00065841:29_0 |
| | | WBPaper00065841:32_0 |
| | | WBPaper00065841:46_0 |
| | | WBPaper00065841:51_1 |
| | | WBPaper00065841:52_0 |
| | | WBPaper00065841:55_0 |
| | | WBPaper00065841:56_0 |
| | | WBPaper00065841:76_0 |
| | | WBPaper00065841:86_0 |
| | | WBPaper00065841:95_0 |
| | | WBPaper00065841:103_0 |
| | | WBPaper00065841:104_0 |
| | | WBPaper00065841:111_0 |
| | | WBPaper00065841:126_0 |
| | | WBPaper00065841:128_0 |
| | | WBPaper00065841:133_0 |
| | | WBPaper00065841:134_0 |
| | | WBPaper00065841:136_0 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4489_group_14 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00040821:Au-NP_regulated |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_3h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00048989:N2_allantoin_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | [cgc6390]:Cluster_B |
| | | [cgc6390]:male_soma-enriched |
| | Interaction (43) |
| | Anatomy_function | WBbtf0233 |
| Map_info | Map | IV | Position | -3.10543 | Error | 0.009454 |
| | Well_ordered |
| | Positive | Positive_clone | RM#5L |
| | | | ZC416 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point (16) |
| | | Multi_point (76) |
| | | Pos_neg_data | 3688 |
| | Landmark_gene |
| Reference (235) |
| Remark | unc-17 only corresponds to ZC416.8a and not ZC416.8b which instead corresponds to the cha-1 gene. |
| Method | Gene |