WormBase Tree Display for Gene: WBGene00006756
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| WBGene00006756 | SMap | S_parent | Sequence | ZC416 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-17 | Person_evidence | WBPerson261 | |||||
| Sequence_name | ZC416.8 | ||||||||
| Molecular_name | ZC416.8a | ||||||||
| ZC416.8a.1 | |||||||||
| CE17307 | |||||||||
| Other_name | CELE_UNC-17 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | unc-17 | ||||||||
| DB_info | Database | AceView | gene | 4E380 | |||||
| WormFlux | gene | WBGene00006756 | |||||||
| NDB | locus_tag | CELE_UNC-17 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006756|UniProtKB=P34711 | |||||||
| family | PTHR23506 | ||||||||
| NCBI | gene | 24105312 | |||||||
| RefSeq | protein | NM_001392284.1 | |||||||
| SwissProt | UniProtAcc | P34711 | |||||||
| UniProt_GCRP | UniProtAcc | P34711 | |||||||
| OMIM | gene | 600336 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143061 | ||||||||
| Allele (128) | |||||||||
| Possibly_affected_by | WBVar02153018 | ||||||||
| Legacy_information | e245 : severe coiler at all stages rather small and thin; resistant to 0.1 mM lannate; suppressed by sup-1 sup-2 and sup-8; normal ChAT (choline acetyltransferase) levels. ES3 ME0. NA > 10 (most alleles resemble e245 or have slightly weaker phenotype; also anomalous alleles e113 (less uncoordinated phenotype drug sensitive loopy movement reduced ChAT levels Egl-c) and e876 (similar)). See also cha-1 : cha-1/unc-17 is probably a complex locus. | ||||||||
| See also e245, e283, e284, e327, e334, e335, e359 | |||||||||
| [C.elegansII] e245 : severe coiler at all stages, rather small and thin; slow irregular pumping;Ric, resistant to 0.1 mM lannate; suppressed by sup-1, sup-2 and sup-8; normal ChAT (choline acetyltransferase) levels. ES3 ME0. OA>10: ut64 (embryonic lethal, coiler, probable null), e335, e464 etc.(most viable alleles resemble e245 or slightly weaker). Also anomalous alleles: e113 (less uncoordinated phenotype, drug sensitive, loopy movement, reduced ChAT levels, Egl-c), e876 (similar), p1156 (Smg suppressible, fails to complement unc-17 and cha-1). cha-1-unc-17 is a complex locus. Cloned: 2 kb transcript, 5' UTR exon shared with cha-1; encodes predicted 532 aa vesicular acetylcholine transporter; 12 TM domains.Antibody staining punctate, most motor synapses. [Alfonso et al. 1993, 1994; AL; RM] | |||||||||
| Strain (45) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (35) | |||||||||
| Ortholog | WBGene00030124 | Caenorhabditis briggsae | From_analysis | Hillier-set | |||||
| OrthoMCL | |||||||||
| OMA | |||||||||
| WBGene00156191 | Caenorhabditis brenneri | From_analysis | OMA | ||||||
| WBGene00161361 | Caenorhabditis brenneri | From_analysis | OMA | ||||||
| WBGene00059160 | Caenorhabditis remanei | From_analysis | OMA | ||||||
| FB:FBgn0270928 | Drosophila melanogaster | From_analysis | EnsEMBL-Compara | ||||||
| Hieranoid | |||||||||
| Inparanoid | |||||||||
| OMA | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| Panther | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| ZFIN:ZDB-GENE-040426-1410 | Danio rerio | From_analysis | EnsEMBL-Compara | ||||||
| Hieranoid | |||||||||
| Inparanoid | |||||||||
| OMA | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| Panther | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| ZFIN:ZDB-GENE-060929-990 | Danio rerio | From_analysis | EnsEMBL-Compara | ||||||
| Hieranoid | |||||||||
| Inparanoid | |||||||||
| OMA | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| Panther | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| HGNC:10936 | Homo sapiens | From_analysis | EnsEMBL-Compara | ||||||
| Hieranoid | |||||||||
| Inparanoid | |||||||||
| OMA | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| Panther | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| MGI:1101061 | Mus musculus | From_analysis | EnsEMBL-Compara | ||||||
| Hieranoid | |||||||||
| Inparanoid | |||||||||
| OMA | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| Panther | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| RGD:62072 | Rattus norvegicus | From_analysis | EnsEMBL-Compara | ||||||
| Hieranoid | |||||||||
| Inparanoid | |||||||||
| OMA | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| Panther | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| Paralog | WBGene00000295 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00018860 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Concise_description | unc-17 encodes a synaptic vesicle acetylcholine transporter (VAChT) highly conserved amongst metazoans including Drosophila and humans (OMIM:600336); UNC-17 is essential for embryonic development, and is required in cholinergic neurons for loading acetylcholine into synaptic vesicles to which UNC-17 is localized; UNC-17 expression may be regulated indirectly by the UNC-4/UNC-37 transcriptional repressor complex, as UNC-17 expression is greatly reduced in unc-4 and unc-37 mutant backgrounds. | Paper_evidence | WBPaper00001770 | |||||
| WBPaper00004594 | |||||||||
| WBPaper00004985 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables acetylcholine transmembrane transporter activity. Involved in several processes, including cholinergic synaptic transmission; nematode larval development; and regulation of pharyngeal pumping. Located in neuron projection; organelle membrane; and synapse. Expressed in neurons; pm2; somatic nervous system; and in male. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and congenital myasthenic syndrome 21. Is an ortholog of human SLC18A3 (solute carrier family 18 member A3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10936) | ||||
| DOID:0110672 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10936) | ||||||
| DOID:12858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10936) | ||||||
| Molecular_info | Corresponding_CDS | ZC416.8a | |||||||
| Corresponding_transcript | ZC416.8a.1 | ||||||||
| Other_sequence (32) | |||||||||
| Associated_feature | WBsf995999 | ||||||||
| WBsf996000 | |||||||||
| WBsf996001 | |||||||||
| WBsf996002 | |||||||||
| WBsf1017092 | |||||||||
| WBsf1017093 | |||||||||
| WBsf1017094 | |||||||||
| WBsf1017095 | |||||||||
| WBsf229908 | |||||||||
| WBsf229909 | |||||||||
| Experimental_info | RNAi_result (21) | ||||||||
| Expr_pattern (16) | |||||||||
| Drives_construct (93) | |||||||||
| Construct_product (15) | |||||||||
| Antibody | WBAntibody00000071 | ||||||||
| WBAntibody00000365 | |||||||||
| WBAntibody00001234 | |||||||||
| WBAntibody00001338 | |||||||||
| WBAntibody00001339 | |||||||||
| WBAntibody00001340 | |||||||||
| WBAntibody00001723 | |||||||||
| WBAntibody00001870 | |||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (148) | |||||||||
| Interaction | WBInteraction000000163 | ||||||||
| WBInteraction000003416 | |||||||||
| WBInteraction000003768 | |||||||||
| WBInteraction000004557 | |||||||||
| WBInteraction000008674 | |||||||||
| WBInteraction000008675 | |||||||||
| WBInteraction000009761 | |||||||||
| WBInteraction000028426 | |||||||||
| WBInteraction000028850 | |||||||||
| WBInteraction000052676 | |||||||||
| WBInteraction000503408 | |||||||||
| WBInteraction000503809 | |||||||||
| WBInteraction000518365 | |||||||||
| WBInteraction000518556 | |||||||||
| WBInteraction000518559 | |||||||||
| WBInteraction000518561 | |||||||||
| WBInteraction000518851 | |||||||||
| WBInteraction000518855 | |||||||||
| WBInteraction000518856 | |||||||||
| WBInteraction000518857 | |||||||||
| WBInteraction000519040 | |||||||||
| WBInteraction000519045 | |||||||||
| WBInteraction000519046 | |||||||||
| WBInteraction000524587 | |||||||||
| WBInteraction000525275 | |||||||||
| WBInteraction000536778 | |||||||||
| WBInteraction000555223 | |||||||||
| WBInteraction000556104 | |||||||||
| WBInteraction000556938 | |||||||||
| WBInteraction000556939 | |||||||||
| WBInteraction000556940 | |||||||||
| WBInteraction000556941 | |||||||||
| WBInteraction000556942 | |||||||||
| WBInteraction000556943 | |||||||||
| WBInteraction000556944 | |||||||||
| WBInteraction000556945 | |||||||||
| WBInteraction000556956 | |||||||||
| WBInteraction000556957 | |||||||||
| WBInteraction000556958 | |||||||||
| WBInteraction000556962 | |||||||||
| WBInteraction000556963 | |||||||||
| WBInteraction000556966 | |||||||||
| WBInteraction000561580 | |||||||||
| Anatomy_function | WBbtf0233 | ||||||||
| Map_info | Map | IV | Position | -3.10543 | Error | 0.009454 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | RM#5L | |||||||
| ZC416 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point (16) | ||||||||
| Multi_point (76) | |||||||||
| Pos_neg_data | 3688 | ||||||||
| Landmark_gene | |||||||||
| Reference (235) | |||||||||
| Remark | unc-17 only corresponds to ZC416.8a and not ZC416.8b which instead corresponds to the cha-1 gene. | ||||||||
| Method | Gene |
