WormBase Tree Display for Gene: WBGene00006756
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WBGene00006756 | SMap | S_parent | Sequence | ZC416 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | unc-17 | Person_evidence | WBPerson261 | |||||
Sequence_name | ZC416.8 | ||||||||
Molecular_name | ZC416.8a | ||||||||
ZC416.8a.1 | |||||||||
CE17307 | |||||||||
Other_name | CELE_UNC-17 | Accession_evidence | NDB | BX284604 | |||||
Public_name | unc-17 | ||||||||
DB_info | Database | AceView | gene | 4E380 | |||||
WormFlux | gene | WBGene00006756 | |||||||
NDB | locus_tag | CELE_UNC-17 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00006756|UniProtKB=P34711 | |||||||
family | PTHR23506 | ||||||||
NCBI | gene | 24105312 | |||||||
RefSeq | protein | NM_001392284.1 | |||||||
SwissProt | UniProtAcc | P34711 | |||||||
UniProt_GCRP | UniProtAcc | P34711 | |||||||
OMIM | gene | 600336 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | unc | ||||||||
Reference_allele | WBVar00143061 | ||||||||
Allele (128) | |||||||||
Possibly_affected_by | WBVar02153018 | ||||||||
Legacy_information | e245 : severe coiler at all stages rather small and thin; resistant to 0.1 mM lannate; suppressed by sup-1 sup-2 and sup-8; normal ChAT (choline acetyltransferase) levels. ES3 ME0. NA > 10 (most alleles resemble e245 or have slightly weaker phenotype; also anomalous alleles e113 (less uncoordinated phenotype drug sensitive loopy movement reduced ChAT levels Egl-c) and e876 (similar)). See also cha-1 : cha-1/unc-17 is probably a complex locus. | ||||||||
See also e245, e283, e284, e327, e334, e335, e359 | |||||||||
[C.elegansII] e245 : severe coiler at all stages, rather small and thin; slow irregular pumping;Ric, resistant to 0.1 mM lannate; suppressed by sup-1, sup-2 and sup-8; normal ChAT (choline acetyltransferase) levels. ES3 ME0. OA>10: ut64 (embryonic lethal, coiler, probable null), e335, e464 etc.(most viable alleles resemble e245 or slightly weaker). Also anomalous alleles: e113 (less uncoordinated phenotype, drug sensitive, loopy movement, reduced ChAT levels, Egl-c), e876 (similar), p1156 (Smg suppressible, fails to complement unc-17 and cha-1). cha-1-unc-17 is a complex locus. Cloned: 2 kb transcript, 5' UTR exon shared with cha-1; encodes predicted 532 aa vesicular acetylcholine transporter; 12 TM domains.Antibody staining punctate, most motor synapses. [Alfonso et al. 1993, 1994; AL; RM] | |||||||||
Strain (45) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (35) | |||||||||
Ortholog | WBGene00030124 | Caenorhabditis briggsae | From_analysis | Hillier-set | |||||
OrthoMCL | |||||||||
OMA | |||||||||
WBGene00156191 | Caenorhabditis brenneri | From_analysis | OMA | ||||||
WBGene00161361 | Caenorhabditis brenneri | From_analysis | OMA | ||||||
WBGene00059160 | Caenorhabditis remanei | From_analysis | OMA | ||||||
FB:FBgn0270928 | Drosophila melanogaster | From_analysis | EnsEMBL-Compara | ||||||
Hieranoid | |||||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
PhylomeDB | |||||||||
SonicParanoid | |||||||||
ZFIN:ZDB-GENE-040426-1410 | Danio rerio | From_analysis | EnsEMBL-Compara | ||||||
Hieranoid | |||||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
PhylomeDB | |||||||||
SonicParanoid | |||||||||
ZFIN:ZDB-GENE-060929-990 | Danio rerio | From_analysis | EnsEMBL-Compara | ||||||
Hieranoid | |||||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
PhylomeDB | |||||||||
SonicParanoid | |||||||||
HGNC:10936 | Homo sapiens | From_analysis | EnsEMBL-Compara | ||||||
Hieranoid | |||||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
PhylomeDB | |||||||||
SonicParanoid | |||||||||
MGI:1101061 | Mus musculus | From_analysis | EnsEMBL-Compara | ||||||
Hieranoid | |||||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
PhylomeDB | |||||||||
SonicParanoid | |||||||||
RGD:62072 | Rattus norvegicus | From_analysis | EnsEMBL-Compara | ||||||
Hieranoid | |||||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
PhylomeDB | |||||||||
SonicParanoid | |||||||||
Paralog | WBGene00000295 | Caenorhabditis elegans | From_analysis | Panther | |||||
WBGene00018860 | Caenorhabditis elegans | From_analysis | Panther | ||||||
Structured_description | Concise_description | unc-17 encodes a synaptic vesicle acetylcholine transporter (VAChT) highly conserved amongst metazoans including Drosophila and humans (OMIM:600336); UNC-17 is essential for embryonic development, and is required in cholinergic neurons for loading acetylcholine into synaptic vesicles to which UNC-17 is localized; UNC-17 expression may be regulated indirectly by the UNC-4/UNC-37 transcriptional repressor complex, as UNC-17 expression is greatly reduced in unc-4 and unc-37 mutant backgrounds. | Paper_evidence | WBPaper00001770 | |||||
WBPaper00004594 | |||||||||
WBPaper00004985 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables acetylcholine transmembrane transporter activity. Involved in several processes, including cholinergic synaptic transmission; nematode larval development; and regulation of pharyngeal pumping. Located in neuron projection; organelle membrane; and synapse. Expressed in neurons; pm2; somatic nervous system; and in male. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and congenital myasthenic syndrome 21. Is an ortholog of human SLC18A3 (solute carrier family 18 member A3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10936) | ||||
DOID:0110672 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10936) | ||||||
DOID:12858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10936) | ||||||
Molecular_info | Corresponding_CDS | ZC416.8a | |||||||
Corresponding_transcript | ZC416.8a.1 | ||||||||
Other_sequence (32) | |||||||||
Associated_feature | WBsf995999 | ||||||||
WBsf996000 | |||||||||
WBsf996001 | |||||||||
WBsf996002 | |||||||||
WBsf1017092 | |||||||||
WBsf1017093 | |||||||||
WBsf1017094 | |||||||||
WBsf1017095 | |||||||||
WBsf229908 | |||||||||
WBsf229909 | |||||||||
Experimental_info | RNAi_result (21) | ||||||||
Expr_pattern (16) | |||||||||
Drives_construct (93) | |||||||||
Construct_product (15) | |||||||||
Antibody | WBAntibody00000071 | ||||||||
WBAntibody00000365 | |||||||||
WBAntibody00001234 | |||||||||
WBAntibody00001338 | |||||||||
WBAntibody00001339 | |||||||||
WBAntibody00001340 | |||||||||
WBAntibody00001723 | |||||||||
WBAntibody00001870 | |||||||||
Microarray_results | SMD_ZC416.8 | ||||||||
172038_x_at | |||||||||
192428_s_at | |||||||||
194229_x_at | |||||||||
A_12_P100326 | |||||||||
Aff_ZC416.8A | |||||||||
GPL19516_CGZ0013375 | |||||||||
GPL19516_CGZ0055863 | |||||||||
GPL21109_Cat_ZC416.8a | |||||||||
GPL21109_ZC416.8a | |||||||||
GPL3518_CE17307 | |||||||||
GPL8673_ZC416_8aP00214 | |||||||||
GPL8673_ZC416_8aP00884 | |||||||||
GPL8673_ZC416_8aP01194 | |||||||||
GPL9450_ZC416.8a | |||||||||
cea2.d.47760 | |||||||||
cea2.d.47770 | |||||||||
Expression_cluster (148) | |||||||||
Interaction (43) | |||||||||
Anatomy_function | WBbtf0233 | ||||||||
Map_info | Map | IV | Position | -3.10543 | Error | 0.009454 | |||
Well_ordered | |||||||||
Positive | Positive_clone | RM#5L | |||||||
ZC416 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Mapping_data | 2_point (16) | ||||||||
Multi_point (76) | |||||||||
Pos_neg_data | 3688 | ||||||||
Landmark_gene | |||||||||
Reference (235) | |||||||||
Remark | unc-17 only corresponds to ZC416.8a and not ZC416.8b which instead corresponds to the cha-1 gene. | ||||||||
Method | Gene |