WormBase Tree Display for Gene: WBGene00006756
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WBGene00006756 | SMap | S_parent | Sequence | ZC416 | |||
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Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00143061 | ||||||
Allele (128) | |||||||
Possibly_affected_by | WBVar02153018 | ||||||
Legacy_information | e245 : severe coiler at all stages rather small and thin; resistant to 0.1 mM lannate; suppressed by sup-1 sup-2 and sup-8; normal ChAT (choline acetyltransferase) levels. ES3 ME0. NA > 10 (most alleles resemble e245 or have slightly weaker phenotype; also anomalous alleles e113 (less uncoordinated phenotype drug sensitive loopy movement reduced ChAT levels Egl-c) and e876 (similar)). See also cha-1 : cha-1/unc-17 is probably a complex locus. | ||||||
See also e245, e283, e284, e327, e334, e335, e359 | |||||||
[C.elegansII] e245 : severe coiler at all stages, rather small and thin; slow irregular pumping;Ric, resistant to 0.1 mM lannate; suppressed by sup-1, sup-2 and sup-8; normal ChAT (choline acetyltransferase) levels. ES3 ME0. OA>10: ut64 (embryonic lethal, coiler, probable null), e335, e464 etc.(most viable alleles resemble e245 or slightly weaker). Also anomalous alleles: e113 (less uncoordinated phenotype, drug sensitive, loopy movement, reduced ChAT levels, Egl-c), e876 (similar), p1156 (Smg suppressible, fails to complement unc-17 and cha-1). cha-1-unc-17 is a complex locus. Cloned: 2 kb transcript, 5' UTR exon shared with cha-1; encodes predicted 532 aa vesicular acetylcholine transporter; 12 TM domains.Antibody staining punctate, most motor synapses. [Alfonso et al. 1993, 1994; AL; RM] | |||||||
Strain (45) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (35) | |||||||
Ortholog | WBGene00030124 | Caenorhabditis briggsae | From_analysis | Hillier-set | |||
OrthoMCL | |||||||
OMA | |||||||
WBGene00156191 | Caenorhabditis brenneri | From_analysis | OMA | ||||
WBGene00161361 | Caenorhabditis brenneri | From_analysis | OMA | ||||
WBGene00059160 | Caenorhabditis remanei | From_analysis | OMA | ||||
FB:FBgn0270928 | Drosophila melanogaster | From_analysis | EnsEMBL-Compara | ||||
Hieranoid | |||||||
Inparanoid | |||||||
OMA | |||||||
OrthoFinder | |||||||
OrthoInspector | |||||||
Panther | |||||||
PhylomeDB | |||||||
SonicParanoid | |||||||
ZFIN:ZDB-GENE-040426-1410 | Danio rerio | From_analysis | EnsEMBL-Compara | ||||
Hieranoid | |||||||
Inparanoid | |||||||
OMA | |||||||
OrthoFinder | |||||||
OrthoInspector | |||||||
Panther | |||||||
PhylomeDB | |||||||
SonicParanoid | |||||||
ZFIN:ZDB-GENE-060929-990 | Danio rerio | From_analysis | EnsEMBL-Compara | ||||
Hieranoid | |||||||
Inparanoid | |||||||
OMA | |||||||
OrthoFinder | |||||||
OrthoInspector | |||||||
Panther | |||||||
PhylomeDB | |||||||
SonicParanoid | |||||||
HGNC:10936 | Homo sapiens | From_analysis | EnsEMBL-Compara | ||||
Hieranoid | |||||||
Inparanoid | |||||||
OMA | |||||||
OrthoFinder | |||||||
OrthoInspector | |||||||
Panther | |||||||
PhylomeDB | |||||||
SonicParanoid | |||||||
MGI:1101061 | Mus musculus | From_analysis | EnsEMBL-Compara | ||||
Hieranoid | |||||||
Inparanoid | |||||||
OMA | |||||||
OrthoFinder | |||||||
OrthoInspector | |||||||
Panther | |||||||
PhylomeDB | |||||||
SonicParanoid | |||||||
RGD:62072 | Rattus norvegicus | From_analysis | EnsEMBL-Compara | ||||
Hieranoid | |||||||
Inparanoid | |||||||
OMA | |||||||
OrthoFinder | |||||||
OrthoInspector | |||||||
Panther | |||||||
PhylomeDB | |||||||
SonicParanoid | |||||||
Paralog | WBGene00000295 | Caenorhabditis elegans | From_analysis | Panther | |||
WBGene00018860 | Caenorhabditis elegans | From_analysis | Panther | ||||
Structured_description | Concise_description | unc-17 encodes a synaptic vesicle acetylcholine transporter (VAChT) highly conserved amongst metazoans including Drosophila and humans (OMIM:600336); UNC-17 is essential for embryonic development, and is required in cholinergic neurons for loading acetylcholine into synaptic vesicles to which UNC-17 is localized; UNC-17 expression may be regulated indirectly by the UNC-4/UNC-37 transcriptional repressor complex, as UNC-17 expression is greatly reduced in unc-4 and unc-37 mutant backgrounds. | Paper_evidence | WBPaper00001770 | |||
WBPaper00004594 | |||||||
WBPaper00004985 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables acetylcholine transmembrane transporter activity. Involved in several processes, including cholinergic synaptic transmission; nematode larval development; and regulation of pharyngeal pumping. Located in neuron projection; organelle membrane; and synapse. Expressed in neurons; pm2; somatic nervous system; and in male. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and congenital myasthenic syndrome 21. Is an ortholog of human SLC18A3 (solute carrier family 18 member A3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10936) | ||
DOID:0110672 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10936) | ||||
DOID:12858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10936) | ||||
Molecular_info | Corresponding_CDS | ZC416.8a | |||||
Corresponding_transcript | ZC416.8a.1 | ||||||
Other_sequence (32) | |||||||
Associated_feature | WBsf995999 | ||||||
WBsf996000 | |||||||
WBsf996001 | |||||||
WBsf996002 | |||||||
WBsf1017092 | |||||||
WBsf1017093 | |||||||
WBsf1017094 | |||||||
WBsf1017095 | |||||||
WBsf229908 | |||||||
WBsf229909 | |||||||
Experimental_info | RNAi_result (21) | ||||||
Expr_pattern (16) | |||||||
Drives_construct (93) | |||||||
Construct_product (15) | |||||||
Antibody | WBAntibody00000071 | ||||||
WBAntibody00000365 | |||||||
WBAntibody00001234 | |||||||
WBAntibody00001338 | |||||||
WBAntibody00001339 | |||||||
WBAntibody00001340 | |||||||
WBAntibody00001723 | |||||||
WBAntibody00001870 | |||||||
Microarray_results (17) | |||||||
Expression_cluster (148) | |||||||
Interaction (43) | |||||||
Anatomy_function | WBbtf0233 | ||||||
Map_info | Map | IV | Position | -3.10543 | Error | 0.009454 | |
Well_ordered | |||||||
Positive | Positive_clone | RM#5L | |||||
ZC416 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point (16) | ||||||
Multi_point (76) | |||||||
Pos_neg_data | 3688 | ||||||
Landmark_gene | |||||||
Reference (235) | |||||||
Remark | unc-17 only corresponds to ZC416.8a and not ZC416.8b which instead corresponds to the cha-1 gene. | ||||||
Method | Gene |