WormBase Tree Display for Variation: WBVar00088923

WBVar00088923 Evidence: Paper_evidence: WBPaper00003903
  Name: Public_name: mg280
    Other_name: ZK1290.2a.1:c.86+68_854del
      ZK1290.2b.1:c.-264+68_545del
    HGVSg: CHROMOSOME_II:g.7549511_7550816del
  Sequence_details: SMap: S_parent: Sequence: ZK1290
    Flanking_sequences: ccgttcaattttgaactgtaggagtgaact atactcggaaaataatattccgcaactaga
    Mapping_target: ZK1290
    Type_of_mutation: Deletion
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00006655
      WBStrain00007901
      WBStrain00027519
      WBStrain00049490
      WBStrain00055118
      WBStrain00055121
    Laboratory: GR
      MT
    Status: Live
  Affects: Gene: WBGene00197293
      WBGene00006600
    Transcript: ZK1290.2b.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: ZK1290.2b.1:c.-264+68_545del
        cDNA_position: ?-875
        CDS_position: ?-545
        Protein_position: ?-182
        Intron_number: 1-6/11
        Exon_number: 2-7/12
      ZK1290.2a.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: ZK1290.2a.1:c.86+68_854del
        cDNA_position: ?-877
        CDS_position: ?-854
        Protein_position: ?-285
        Intron_number: 2-7/12
        Exon_number: 3-8/13
      ZK1290.18 VEP_consequence: non_coding_transcript_exon_variant
        VEP_impact: MODIFIER
        cDNA_position: ?-74
        Exon_number: 1/1
    Interactor: WBInteraction000500144
      WBInteraction000502728
      WBInteraction000525337
      WBInteraction000537565
      WBInteraction000537566
      WBInteraction000541577
  Genetics: Interpolated_map_position: II 0.504577
    Mapping_data: In_multi_point: 4733
  Description: Phenotype (45)
    Phenotype_not_observed: WBPhenotype:0000306 Paper_evidence: WBPaper00050142
        Curator_confirmed: WBPerson2987
        Remark: "As a control for the specificity of serotonergic signaling to neuronal and cell-non-autonomous induction of the response, we exposed tph-1 mutant animals to cell-autonomous stressors, namely paraquat and cco-1 RNAi. These strains showed the same level of induction of hsp-6::GFP as controls, indicating that serotonin is required specifically for neuronal initiation of this response (Figure S4D)." Paper_evidence: WBPaper00050142
            Curator_confirmed: WBPerson2987
        Affected_by: Molecule: WBMol:00002747 Paper_evidence: WBPaper00050142
              Curator_confirmed: WBPerson2987
        EQ_annotations: GO_term: GO:0034514 PATO:0000460 Paper_evidence: WBPaper00050142
                Curator_confirmed: WBPerson2987
        Phenotype_assay: Genotype: zcIs13 [hsp-6p::GFP] Paper_evidence: WBPaper00050142
              Curator_confirmed: WBPerson2987
            zcIs13 [hsp-6p::GFP]; cco-1(RNAi) Paper_evidence: WBPaper00050142
              Curator_confirmed: WBPerson2987
      WBPhenotype:0000631 Paper_evidence: WBPaper00035198
        Curator_confirmed: WBPerson712
        Remark: Animals do not exhibit anterior convulsions when treated with pentylenetetrazole(PTZ). Paper_evidence: WBPaper00035198
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00004251 Paper_evidence: WBPaper00035198
              Curator_confirmed: WBPerson712
      WBPhenotype:0001068 Paper_evidence: WBPaper00031241
        Curator_confirmed: WBPerson712
        Remark: Pre-exposure to mianserin blocked serotonin-induced egg laying as it does for N2 animals. Paper_evidence: WBPaper00031241
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00031241
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Animals were pre-exposed to 50uM mianserin. Paper_evidence: WBPaper00031241
              Curator_confirmed: WBPerson712
      WBPhenotype:0001072 Paper_evidence: WBPaper00035327
        Curator_confirmed: WBPerson2021
        Remark: tph-1 mutants displayed a wild type phenotype on non-eatable food Paper_evidence: WBPaper00035327
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001101 Paper_evidence: WBPaper00038382
        Curator_confirmed: WBPerson712
        Remark: Clozapine-induced increases in egg laying was present. Paper_evidence: WBPaper00038382
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003634 Paper_evidence: WBPaper00038382
              Curator_confirmed: WBPerson712
      WBPhenotype:0001765 Paper_evidence: WBPaper00031936
        Curator_confirmed: WBPerson2021
        Remark: Mutants defective in the synthesis and reception of nonessential excitatory neurotransmitters respond normally to CO2 Paper_evidence: WBPaper00031936
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00031936
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 10% CO2 Paper_evidence: WBPaper00031936
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001780 Paper_evidence: WBPaper00029060
        Curator_confirmed: WBPerson2021
        Remark: Mutants show normal butanone enhancement Paper_evidence: WBPaper00029060
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00029060
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: Preexposure to 1:10 dilution of butanone and food. Animals were then subjected to odorant chemotaxis assays and/or selection assays Paper_evidence: WBPaper00029060
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001817 Paper_evidence: WBPaper00032335
        Curator_confirmed: WBPerson712
        Remark: Animals exhibited enhanced-gustatory plasticity, i.e. strong avoidance to NaCl after starvation, similar to that observed for wild type. Paper_evidence: WBPaper00032335
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003571 Paper_evidence: WBPaper00032335
              Curator_confirmed: WBPerson712
  Disease_info: Models_disease: DOID:809
      DOID:1574
    Models_disease_in_annotation: WBDOannot00000681
      WBDOannot00000714
  Reference (41)
  Remark: Variation stub generated from the April 2021 NN VFP dataset.
    Variation stub/paper connection generated from the May 2021 NN VFP dataset.
    Created by WBPerson1983 from the NN_VFP_triage_pipeline
  Method: Deletion_allele