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WormBase Tree Display for WBProcess: WBbiopr:00000025

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Name Class

WBbiopr:00000025Public_nameDauer development
SummaryNematodes like C. elegans can survive the harshest of environmental conditions by adopting an alternative developmental program and entering into the dauer state. Dauer stage worms are reproductively immature. Entry into or exit from dauer in C. elegans is a carefully weighted decision taking into account factors such as food availability and population density, which is measured by pheromone levels in the population. Dauer development entails metabolic changes, such as increasing fat storage, and remodeling of tissues leading to the arrest of normal developmental programs, and a significant increase in lifespan. These metabolic and physiological changes are choreographed by changes in gene expression. One gene in particular, daf-16, a homolog of the human FKHR and AFX genes, appears to play a major transcriptional regulatory role in this process. A second key gene, a receptor tyrosine kinase and insulin/IGF receptor ortholog, daf-2, negatively regulates daf-16. Mutations in daf-2 result in a Dauer consititute phenotype and an extended lifespan. The C. elegans dauer stage larvae are often equated with the IJ infective juvenile stage larvae of parasitic nematodes.
Other_namediapause, hypobiosis
Related_topicSpecialisation_ofWBbiopr:00000026
Involved_entityGeneWBGene00000908Paper_evidenceWBPaper00027307
WBPaper00002149
WBGene00000936Paper_evidenceWBPaper00027307
WBGene00016673Paper_evidenceWBPaper00049337
WBGene00004265Paper_evidenceWBPaper00049337
WBGene00000907
WBGene00000897Paper_evidenceWBPaper00027307
WBGene00005193Paper_evidenceWBPaper00049337
WBGene00012169Paper_evidenceWBPaper00049337
WBGene00000491Paper_evidenceWBPaper00049337
WBGene00000102Paper_evidenceWBPaper00031180
WBPaper00003568
WBGene00001165Paper_evidenceWBPaper00027307
WBGene00000905Paper_evidenceWBPaper00027606
WBGene00003017Paper_evidenceWBPaper00027307
WBGene00000913Paper_evidenceWBPaper00031180
WBPaper00002149
WBGene00021594Paper_evidenceWBPaper00027307
WBGene00000090Paper_evidenceWBPaper00031180
WBPaper00002149
WBPaper00003568
WBGene00000903Paper_evidenceWBPaper00027307
WBGene00000900Paper_evidenceWBPaper00027307
WBGene00006445Paper_evidenceWBPaper00027307
WBGene00005194Paper_evidenceWBPaper00049337
WBGene00000910Paper_evidenceWBPaper00027307
WBGene00000920Paper_evidenceWBPaper00031180
WBGene00009324Paper_evidenceWBPaper00049337
WBGene00004048Paper_evidenceWBPaper00027307
WBGene00011111Paper_evidenceWBPaper00027307
WBGene00011283Paper_evidenceWBPaper00049337
WBGene00007305Paper_evidenceWBPaper00049337
WBGene00017066Paper_evidenceWBPaper00049337
WBGene00003111Paper_evidenceWBPaper00027307
WBGene00006776Paper_evidenceWBPaper00027307
WBGene00000901Paper_evidenceWBPaper00027307
WBGene00001437Paper_evidenceWBPaper00027307
WBGene00001198Paper_evidenceWBPaper00027307
WBGene00000898Paper_evidenceWBPaper00031180
WBPaper00002149
WBPaper00003568
WBGene00003965Paper_evidenceWBPaper00031180
WBPaper00003568
WBGene00000103Paper_evidenceWBPaper00031180
WBPaper00003568
WBGene00010923Paper_evidenceWBPaper00031180
WBGene00001502Paper_evidenceWBPaper00031180
WBGene00000912Paper_evidenceWBPaper00031180
WBPaper00002914
WBPaper00002149
WBPaper00003568
WBGene00000262Paper_evidenceWBPaper00027307
WBGene00000437Paper_evidenceWBPaper00027307
WBGene00000899Paper_evidenceWBPaper00027307
WBGene00000904Paper_evidenceWBPaper00027307
WBGene00000915Paper_evidenceWBPaper00027307
WBGene00001173Paper_evidenceWBPaper00027307
WBGene00003055Paper_evidenceWBPaper00027307
WBGene00003057Paper_evidenceWBPaper00027307
WBGene00004393Paper_evidenceWBPaper00027307
WBGene00004855Paper_evidenceWBPaper00027307
WBGene00004856Paper_evidenceWBPaper00027307
WBGene00004857Paper_evidenceWBPaper00027307
WBGene00004858Paper_evidenceWBPaper00027307
WBGene00004860Paper_evidenceWBPaper00027307
WBGene00004862Paper_evidenceWBPaper00027307
WBGene00006570Paper_evidenceWBPaper00027307
WBGene00006652Paper_evidenceWBPaper00027307
WBGene00006745Paper_evidenceWBPaper00027307
WBGene00006746Paper_evidenceWBPaper00027307
WBGene00006852Paper_evidenceWBPaper00027307
WBGene00006525
WBGene00006526
Expression_clusterWBPaper00024393:strongly_regulated_dauer_genesPaper_evidenceWBPaper00024393
WBPaper00034739:N2lessDR1350Paper_evidenceWBPaper00034739
WBPaper00034739:N2moreDR1350Paper_evidenceWBPaper00034739
WBPaper00034739:RIL17lessRIL14Paper_evidenceWBPaper00034739
WBPaper00034739:RIL17moreRIL14Paper_evidenceWBPaper00034739
WBPaper00034739:TreatmentAffectedGenesPaper_evidenceWBPaper00034739
Interaction (558)
Anatomy_termWBbt:0005666Paper_evidenceWBPaper00049337
WBbt:0005668Paper_evidenceWBPaper00049337
Life_stageWBls:0000032Paper_evidenceWBPaper00031180
WBPaper00027606
WBPaper00027307
WBls:0000041Paper_evidenceWBPaper00002149
MoleculeWBMol:00005103Paper_evidenceWBPaper00049337
WBMol:00005104Paper_evidenceWBPaper00049337
WBMol:00005106Paper_evidenceWBPaper00049337
WBMol:00005110Paper_evidenceWBPaper00049337
WBMol:00005127Paper_evidenceWBPaper00049337
Associated_with (2)
PathwayDB_infoDatabaseWikiPathwaysPathwayWP580
Remark"WikiPathways" "Pathway" "WP580"
Reference (11)