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WormBase Tree Display for WBProcess: WBbiopr:00000073

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Name Class

WBbiopr:00000073Public_nameWnt signaling pathway
SummaryWnt glycoproteins are signaling molecules that control a wide range of developmental processes and is a conserved feature of metazoan development. In C. elegans Wnt signaling has been shown to play a role in cell fate specification and determination of cell polarity, cell migration, and axis determination during axon outgrowth. A 'canonical' Wnt signaling pathway has been elucidated in vertebrate and invertebrate model systems where Wnt binding leads to the stabilization of the transcription factor beta-catenin, which then enters the nucleus to regulate Wnt pathway target genes. Like other species, the C. elegans genome encodes multiple genes for Wnt ligands, EGL-20, LIN-44, MOM-2, CWN-1, CWN-2) and Wnt receptors (LIN-17, MOM-5, MIG-1, CFZ-2, LIN-18). Canonical Wnt signaling in C. elegans, utilizes the beta-catenin BAR-1 to convert POP-1 into an activator and controls the expression of several homeobox genes. However, unlike vertebrates or Drosophila, the C. elegans genome encodes multiple beta-catenin genes (HMP-2, BAR-1, SYS-1, WRM-1), which give rise to noncanonical Wnt signalling pathways: for example, the endoderm induction pathway requires the beta-catenin WRM-1 and parallel input from a mitogen-activated kinase (MAPK) pathway to downregulate POP-1.
Other_nameWnt signalling pathway
Related_topicSpecialisation_ofWBbiopr:00000020
WBbiopr:00000024
WBbiopr:00000094
WBbiopr:00000112
WBbiopr:00000107
WBbiopr:00000110
WBbiopr:00000114
Involved_entityGeneWBGene00000939Paper_evidenceWBPaper00036466
WBGene00006933Paper_evidenceWBPaper00027192
WBPaper00027355
WBGene00001980Paper_evidenceWBPaper00036330
WBGene00007029Paper_evidenceWBPaper00027756
WBGene00003479Paper_evidenceWBPaper00037794
WBGene00004732Paper_evidenceWBPaper00036330
WBGene00012230Paper_evidenceWBPaper00045459
WBGene00006943Paper_evidenceWBPaper00037107
WBGene00003029Paper_evidenceWBPaper00041245
WBPaper00027140
WBPaper00027141
WBPaper00027192
WBGene00000858Paper_evidenceWBPaper00041245
WBPaper00027140
WBPaper00035405
WBPaper00037046
WBGene00006379Paper_evidenceWBPaper00027082
WBGene00006554Paper_evidenceWBPaper00027745
WBGene00006770Paper_evidenceWBPaper00036239
WBGene00003006Paper_evidenceWBPaper00041245
WBPaper00027141
WBGene00003478Paper_evidenceWBPaper00037794
WBGene00003007Paper_evidenceWBPaper00041245
WBGene00008549Paper_evidenceWBPaper00027756
WBGene00007028Paper_evidenceWBPaper00027756
WBGene00000289Paper_evidenceWBPaper00035405
WBPaper00037046
WBGene00003397Paper_evidenceWBPaper00041245
WBPaper00027142
WBGene00006931Paper_evidenceWBPaper00027192
WBGene00001487Paper_evidenceWBPaper00037107
WBGene00000478Paper_evidenceWBPaper00041245
WBPaper00035405
WBPaper00037046
WBGene00003246Paper_evidenceWBPaper00027609
WBGene00000156Paper_evidenceWBPaper00037107
WBGene00001188Paper_evidenceWBPaper00041245
WBPaper00027140
WBPaper00027192
WBPaper00027355
WBGene00003395Paper_evidenceWBPaper00041245
WBPaper00027140
WBGene00000857Paper_evidenceWBPaper00041245
WBPaper00027140
WBPaper00027141
WBGene00003238Paper_evidenceWBPaper00041245
WBPaper00035405
WBPaper00037046
WBGene00004393Paper_evidenceWBPaper00026860
WBGene00003864Paper_evidenceWBPaper00026975
WBGene00001746Paper_evidenceWBPaper00026975
WBGene00002202Paper_evidenceWBPaper00026975
WBPaper00037838
WBGene00003024Paper_evidenceWBPaper00027035
WBGene00000445Paper_evidenceWBPaper00027082
WBGene00004077Paper_evidenceWBPaper00027082
WBPaper00044833
WBPaper00045459
WBGene00003219Paper_evidenceWBPaper00027142
WBGene00003102Paper_evidenceWBPaper00027355
WBGene00009560Paper_evidenceWBPaper00027741
WBGene00003777Paper_evidenceWBPaper00035593
WBGene00000868Paper_evidenceWBPaper00036019
WBGene00000405Paper_evidenceWBPaper00036019
WBGene00006974Paper_evidenceWBPaper00036019
WBGene00001174Paper_evidenceWBPaper00036386
WBGene00003048Paper_evidenceWBPaper00036466
WBGene00001979Paper_evidenceWBPaper00037107
Interaction (66)
Anatomy_term (15)
Associated_withPhenotypeWBPhenotype:0000104Paper_evidenceWBPaper00027192
GO_termGO:0016055
GO:0060070
Picture (17)
Reference (302)