WormBase Tree Display for Gene: WBGene00004729

WBGene00004729 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 2
    Name: CGC_name: sax-3 Person_evidence: WBPerson42
      Sequence_name: ZK377.2
      Molecular_name: ZK377.2a
        ZK377.2a.1
        CE25688
        ZK377.2b
        CE31267
        ZK377.2b.1
      Other_name: CELE_ZK377.2 Accession_evidence: NDB BX284606
      Public_name: sax-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 02 Mar 2018 11:09:16 WBPerson4025 Event: Split_into: WBGene00303098
      Split_into: WBGene00303098
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sax
    Allele: WBVar00088418 Inferred_automatically: From strain object: CX3171
      WBVar00088406 Inferred_automatically: From strain object: CX3198
          From strain object: IC361
          From strain object: IC459
          From strain object: IC464
          From strain object: IC476
          From strain object: IC699
      WBVar00499132
      WBVar01133888
      WBVar00499133
      WBVar01133889
      WBVar01133890
      WBVar00499134
      WBVar01133891
      WBVar00499135
      WBVar00499136
      WBVar01825047
      WBVar01133892
      WBVar00499137
      WBVar01133893
      WBVar00499138
      WBVar01133894
      WBVar00499139
      WBVar01133895
      WBVar01133896
      WBVar00499140
      WBVar01133897
      WBVar00499141
      WBVar00499142
      WBVar02056360
      WBVar01133898
      WBVar01133899
      WBVar00499143
      WBVar00077121
      WBVar00499144
      WBVar01133900
      WBVar00077122
      WBVar00499145
      WBVar01133901
      WBVar00077123
      WBVar00088416
      WBVar01133902
      WBVar00499146
      WBVar00499147
      WBVar01133903
      WBVar00088420
      WBVar01133904
      WBVar01133905
      WBVar01133906
      WBVar01133907
      WBVar01133908
      WBVar01133909
      WBVar01133910
      WBVar01133911
      WBVar01133912
      WBVar01133913
      WBVar01133914
      WBVar01133915
      WBVar01133916
      WBVar01133917
      WBVar01133918
      WBVar01133919
      WBVar01133920
      WBVar01133921
      WBVar01133922
      WBVar01133923
      WBVar01133924
      WBVar01133925
      WBVar01133926
      WBVar01819554
      WBVar01133927
      WBVar01133928
      WBVar01133929
      WBVar01133930
      WBVar01133931
      WBVar01133932
      WBVar01945140
      WBVar01133933
      WBVar01133934
      WBVar01133935
      WBVar01133936
      WBVar01133937
      WBVar01133938
      WBVar02026922
      WBVar02026923
      WBVar01133939
      WBVar02111081
      WBVar01133940
      WBVar01133941
      WBVar01133942
      WBVar02153697
      WBVar01133943
      WBVar01133944
      WBVar01133945
      WBVar01133946
      WBVar01133947
      WBVar01133948
      WBVar01486695
      WBVar02044495
      WBVar01133949
      WBVar02044496
      WBVar01133950
      WBVar01133951
      WBVar01133952
      WBVar01133953
      WBVar01133954
      WBVar01133955
      WBVar01133956
      WBVar01133957
      WBVar01133958
      WBVar01980154
      WBVar01133959
      WBVar01133960
      WBVar01133961
      WBVar01133962
      WBVar01133963
      WBVar01133964
      WBVar01133965
      WBVar01133966
      WBVar01133967
      WBVar01133968
      WBVar01133969
      WBVar01133970
      WBVar01133971
      WBVar01133972
      WBVar01133973
      WBVar01133974
      WBVar01133975
      WBVar01133976
      WBVar01133977
      WBVar01133978
      WBVar01133979
      WBVar01133980
      WBVar01133981
      WBVar01496664
      WBVar01133982
      WBVar01133983
      WBVar02152624
      WBVar01133984
      WBVar01133985
      WBVar01133986
      WBVar01601369
      WBVar01601370
      WBVar01601371
      WBVar01998626
      WBVar01499636
      WBVar01661389
      WBVar01468283
      WBVar01468284
      WBVar01468285
      WBVar01468286
      WBVar01468287
      WBVar02139019
      WBVar02139020
      WBVar00499117
      WBVar00499118
      WBVar00499119
      WBVar00499120
      WBVar00499121
      WBVar00499122
      WBVar00499123
      WBVar00499124
      WBVar00499125
      WBVar02148417
      WBVar00499126
      WBVar00499127
      WBVar02048722
      WBVar01133884
      WBVar00499128
      WBVar01133885
      WBVar00499129
      WBVar00499130
      WBVar01133886
      WBVar01500067
      WBVar01133887
      WBVar00499131
    Legacy_information: [Zallen JA] ky123 recessive, homozygotes exhibit aberrant anterior position of nerve ring, many ring axons misrouted, ventral nerve cord neurons often misrouted, cross midline. Encodes three isoforms, longest 1273 aa with 5 Ig repeats, 3 FNIII repeats, TM domain, large cytoplasmic domain. ky123 deletes signal sequence and first exon, probable null. Predicted gene ZK377.3 + ZK377.2
    Strain (11)
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (50)
    Paralog (22)
    Structured_description: Concise_description: sax-3 encodes, by alternative splicing, two isoforms of an ortholog of Drosophila ROUNDABOUT, ROBO3, and LEAK, and of human ROBO1, ROBO2 (OMIM:602431, mutated in vesicoureteral reflux), and ROBO3 (OMIM:608630, mutated in horizontal gaze palsy with progressive scoliosis); in larval hermaphrodites, SAX-3 is required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance. Paper_evidence: WBPaper00003665
            WBPaper00004362
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 24 Jan 2008 00:00:00
      Automated_description: Enables axon guidance receptor activity. Involved in generation of neurons and regulation of sensory neuron axon guidance. Located in plasma membrane. Expressed in several structures, including QR.a; QR.p; body wall musculature; neuroblasts; and neurons. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital nystagmus; hematologic cancer (multiple); and myositis (multiple). Is an ortholog of human ROBO1 (roundabout guidance receptor 1); ROBO2 (roundabout guidance receptor 2); and ROBO3 (roundabout guidance receptor 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (11)
  Molecular_info: Corresponding_CDS: ZK377.2a
      ZK377.2b
    Corresponding_CDS_history: ZK377.2c:wp264
    Corresponding_transcript: ZK377.2a.1
      ZK377.2b.1
    Other_sequence (32)
    Associated_feature (39)
  Experimental_info: RNAi_result: WBRNAi00086088 Inferred_automatically: RNAi_primary
      WBRNAi00086133 Inferred_automatically: RNAi_primary
      WBRNAi00009468 Inferred_automatically: RNAi_primary
      WBRNAi00009467 Inferred_automatically: RNAi_primary
      WBRNAi00067130 Inferred_automatically: RNAi_primary
      WBRNAi00059385 Inferred_automatically: RNAi_primary
    Expr_pattern (17)
    Drives_construct: WBCnstr00001914
      WBCnstr00003185
      WBCnstr00006455
      WBCnstr00009445
      WBCnstr00012503
      WBCnstr00016209
      WBCnstr00035424
      WBCnstr00039977
      WBCnstr00041184
    Construct_product (15)
    Microarray_results (28)
    Expression_cluster (134)
    Interaction (262)
    Anatomy_function: WBbtf0177
  Map_info: Map: X Position: -10.3398 Error: 0.007528
    Well_ordered
    Positive: Inside_rearr: mnDp57
      Positive_clone: R06A1
        ZK377 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3695
        3696
        4758
      Pos_neg_data: 9401
  Reference: WBPaper00002991
    WBPaper00002997
    WBPaper00003665
    WBPaper00003674
    WBPaper00003760
    WBPaper00003949
    WBPaper00004362
    WBPaper00004695
    WBPaper00004900
    WBPaper00005236
    WBPaper00005237
    WBPaper00005251
    WBPaper00005544
    WBPaper00005719
    WBPaper00005760
    WBPaper00006025
    WBPaper00006052
    WBPaper00006185
    WBPaper00006288
    WBPaper00006471
    WBPaper00010168
    WBPaper00011128
    WBPaper00012380
    WBPaper00013450
    WBPaper00015626
    WBPaper00015717
    WBPaper00016704
    WBPaper00017099
    WBPaper00017383
    WBPaper00017429
    WBPaper00017433
    WBPaper00017704
    WBPaper00017711
    WBPaper00017712
    WBPaper00018333
    WBPaper00018335
    WBPaper00018572
    WBPaper00018582
    WBPaper00018588
    WBPaper00018942
    WBPaper00019306
    WBPaper00019311
    WBPaper00022845
    WBPaper00022847
    WBPaper00023013
    WBPaper00023085
    WBPaper00023161
    WBPaper00023199
    WBPaper00023310
    WBPaper00023315
    WBPaper00023401
    WBPaper00023980
    WBPaper00024140
    WBPaper00024195
    WBPaper00024484
    WBPaper00024524
    WBPaper00024525
    WBPaper00024722
    WBPaper00024939
    WBPaper00026115
    WBPaper00026148
    WBPaper00026343
    WBPaper00026416
    WBPaper00026439
    WBPaper00026680
    WBPaper00026825
    WBPaper00026845
    WBPaper00026866
    WBPaper00027119
    WBPaper00027206
    WBPaper00027335
    WBPaper00027618
    WBPaper00027646
    WBPaper00028085
    WBPaper00028566
    WBPaper00029024
    WBPaper00029052
    WBPaper00029053
    WBPaper00030317
    WBPaper00031043
    WBPaper00031067
    WBPaper00031543
    WBPaper00031651
    WBPaper00031671
    WBPaper00031828
    WBPaper00032413
    WBPaper00032446
    WBPaper00032941
    WBPaper00033533
    WBPaper00034526
    WBPaper00035405
    WBPaper00036313
    WBPaper00037014
    WBPaper00037766
    WBPaper00038491
    WBPaper00038504
    WBPaper00038663
    WBPaper00038670
    WBPaper00039166
    WBPaper00039177
    WBPaper00039204
    WBPaper00040041
    WBPaper00040048
    WBPaper00040235
    WBPaper00042082
    WBPaper00042510
    WBPaper00042766
    WBPaper00042977
    WBPaper00043290
    WBPaper00043374
    WBPaper00043453
    WBPaper00044158
    WBPaper00045899
    WBPaper00045955
    WBPaper00046690
    WBPaper00047484
    WBPaper00047772
    WBPaper00047944
    WBPaper00047958
    WBPaper00048281
    WBPaper00050480
    WBPaper00051142
    WBPaper00051935
    WBPaper00053739
    WBPaper00054187
    WBPaper00055090
    WBPaper00055566
    WBPaper00055911
    WBPaper00056066
    WBPaper00056135
    WBPaper00056294
    WBPaper00056384
    WBPaper00056692
    WBPaper00056744
    WBPaper00060014
    WBPaper00060641
    WBPaper00061219
    WBPaper00063298
    WBPaper00063743
    WBPaper00064099
    WBPaper00064636
    WBPaper00064805
    WBPaper00065184
  Remark: Inferred from Zallen et al. (1998)
    2 predicted genes (see phenotype) have been merged. [sdm 05/00]
  Method: Gene