WormBase Tree Display for Gene: WBGene00002232
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WBGene00002232 | SMap | S_parent | Sequence | F11A6 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | kpc-1 | Person_evidence | WBPerson533 | |||||
Sequence_name | F11A6.1 | ||||||||
Molecular_name (5) | |||||||||
Other_name | CELE_F11A6.1 | Accession_evidence | NDB | BX284601 | |||||
Public_name | kpc-1 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | kpc | ||||||||
Allele | WBVar02147405 | ||||||||
WBVar02147404 | |||||||||
WBVar02158322 | |||||||||
WBVar01663665 | |||||||||
WBVar00145464 | |||||||||
WBVar01346290 | |||||||||
WBVar00317711 | |||||||||
WBVar01499739 | |||||||||
WBVar02152385 | |||||||||
WBVar02002018 | |||||||||
WBVar02095431 | |||||||||
WBVar00346465 | |||||||||
WBVar02128576 | |||||||||
WBVar00346466 | |||||||||
WBVar02128577 | |||||||||
WBVar00250121 | |||||||||
WBVar00346467 | |||||||||
WBVar00346468 | |||||||||
WBVar02128578 | |||||||||
WBVar02128579 | |||||||||
WBVar00346469 | |||||||||
WBVar02128580 | |||||||||
WBVar00346470 | |||||||||
WBVar00346471 | |||||||||
WBVar00346472 | |||||||||
WBVar00346473 | |||||||||
WBVar00346474 | |||||||||
WBVar00346475 | |||||||||
WBVar00346476 | |||||||||
WBVar00157578 | |||||||||
WBVar00346477 | |||||||||
WBVar00346478 | |||||||||
WBVar00157579 | |||||||||
WBVar00157580 | |||||||||
WBVar00346479 | |||||||||
WBVar00157581 | |||||||||
WBVar00321411 | |||||||||
WBVar00157582 | |||||||||
WBVar00157583 | |||||||||
WBVar00157584 | |||||||||
WBVar00157585 | |||||||||
WBVar01713358 | |||||||||
WBVar00157586 | |||||||||
WBVar00157587 | |||||||||
WBVar01713359 | |||||||||
WBVar01713360 | |||||||||
WBVar01713361 | |||||||||
WBVar02147403 | |||||||||
WBVar01392182 | |||||||||
WBVar01532283 | |||||||||
WBVar01499788 | |||||||||
WBVar01499054 | |||||||||
WBVar01988539 | |||||||||
WBVar02083890 | |||||||||
WBVar01801377 | |||||||||
WBVar00539708 | |||||||||
WBVar01957877 | |||||||||
WBVar00539711 | |||||||||
WBVar00673957 | |||||||||
WBVar00673958 | |||||||||
WBVar00673959 | |||||||||
WBVar00673960 | |||||||||
WBVar00673961 | |||||||||
WBVar00673962 | |||||||||
WBVar00673963 | |||||||||
WBVar00673964 | |||||||||
WBVar00673965 | |||||||||
WBVar00673966 | |||||||||
WBVar00673967 | |||||||||
WBVar00673968 | |||||||||
WBVar00673969 | |||||||||
WBVar00673970 | |||||||||
WBVar00673971 | |||||||||
WBVar00673972 | |||||||||
WBVar00673973 | |||||||||
WBVar00673974 | |||||||||
WBVar00673975 | |||||||||
WBVar00673976 | |||||||||
WBVar00673977 | |||||||||
WBVar00673978 | |||||||||
WBVar00673979 | |||||||||
WBVar00673980 | |||||||||
WBVar01932646 | |||||||||
WBVar00673981 | |||||||||
WBVar00673982 | |||||||||
WBVar00673983 | |||||||||
WBVar00673984 | |||||||||
WBVar00673985 | |||||||||
WBVar00673986 | |||||||||
WBVar00673987 | |||||||||
WBVar01433264 | |||||||||
WBVar00673988 | |||||||||
WBVar00673989 | |||||||||
WBVar00673990 | |||||||||
WBVar00673991 | |||||||||
WBVar01411862 | |||||||||
WBVar01890246 | |||||||||
WBVar00673992 | |||||||||
WBVar00673993 | |||||||||
WBVar01411863 | |||||||||
WBVar01285312 | |||||||||
WBVar01411864 | |||||||||
WBVar01285314 | |||||||||
WBVar01285315 | |||||||||
WBVar01285316 | |||||||||
WBVar01285319 | |||||||||
WBVar02145406 | |||||||||
WBVar02145407 | |||||||||
WBVar00319580 | |||||||||
WBVar02125009 | |||||||||
WBVar02145408 | |||||||||
WBVar02016480 | |||||||||
WBVar02016481 | |||||||||
WBVar02033030 | |||||||||
WBVar01498959 | |||||||||
Strain | WBStrain00035504 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (48) | |||||||||
Ortholog (49) | |||||||||
Paralog | WBGene00000088 | Caenorhabditis elegans | From_analysis (3) | ||||||
WBGene00000254 | Caenorhabditis elegans | From_analysis (2) | |||||||
WBGene00001172 | Caenorhabditis elegans | From_analysis (3) | |||||||
WBGene00017686 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
Structured_description | Concise_description | kpc-1 encodes two isoforms of a Kex2/subtilisin-like proprotein convertase that is a member of the subtilase family of calcium-dependent serine endoproteinases that includes mammalian furin (OMIM:136950) and Saccharomyces cerevisiae Kex2p; KPC-1 is required for normal growth and locomotion and is likely responsible for the processing of transforming growth factor (TGF) beta proproteins encoded by daf-7, dbl-1, and unc-129. | Paper_evidence | WBPaper00004142 | |||||
WBPaper00018607 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables serine-type endopeptidase activity and signaling receptor binding activity. Involved in several processes, including neuron development; positive regulation of developmental process; and protein processing. Located in neuronal cell body. Expressed in several structures, including PVD; epithelial cell; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in arteriosclerosis; colon adenocarcinoma; and colorectal adenocarcinoma. Is an ortholog of human FURIN (furin, paired basic amino acid cleaving enzyme). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:234 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8747) | ||||
DOID:2349 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8568) | ||||||
DOID:0050861 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8746) | ||||||
Molecular_info | Corresponding_CDS | F11A6.1a | |||||||
Corresponding_CDS_history | F11A6.1b:wp245 | ||||||||
Corresponding_transcript | F11A6.1b | ||||||||
F11A6.1a.1 | |||||||||
F11A6.1a.2 | |||||||||
Other_sequence (36) | |||||||||
Associated_feature (22) | |||||||||
Experimental_info | RNAi_result | WBRNAi00116836 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00003363 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00089035 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00106792 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00044358 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00027714 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (11) | |||||||||
Drives_construct | WBCnstr00018109 | ||||||||
WBCnstr00018110 | |||||||||
WBCnstr00020063 | |||||||||
Construct_product | WBCnstr00018110 | ||||||||
WBCnstr00018228 | |||||||||
WBCnstr00019277 | |||||||||
WBCnstr00043014 | |||||||||
Microarray_results (39) | |||||||||
Expression_cluster (198) | |||||||||
Interaction (29) | |||||||||
Map_info | Map | I | Position | 9.53611 | Error | 0.019245 | |||
Positive | Positive_clone | F11A6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4460 | |||||||
4467 | |||||||||
Pseudo_map_position | |||||||||
Reference (28) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |