WormBase Tree Display for Gene: WBGene00002232
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| WBGene00002232 | SMap | S_parent | Sequence | F11A6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | kpc-1 | Person_evidence | WBPerson533 | |||||
| Sequence_name | F11A6.1 | ||||||||
| Molecular_name | F11A6.1a | ||||||||
| F11A6.1a.1 | |||||||||
| CE17653 | |||||||||
| F11A6.1a.2 | |||||||||
| F11A6.1b | |||||||||
| Other_name | CELE_F11A6.1 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | kpc-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | kpc | ||||||||
| Allele | WBVar02147405 | ||||||||
| WBVar02147404 | |||||||||
| WBVar02158322 | |||||||||
| WBVar01663665 | |||||||||
| WBVar00145464 | |||||||||
| WBVar01346290 | |||||||||
| WBVar00317711 | |||||||||
| WBVar01499739 | |||||||||
| WBVar02152385 | |||||||||
| WBVar02002018 | |||||||||
| WBVar02095431 | |||||||||
| WBVar00346465 | |||||||||
| WBVar02128576 | |||||||||
| WBVar00346466 | |||||||||
| WBVar02128577 | |||||||||
| WBVar00250121 | |||||||||
| WBVar00346467 | |||||||||
| WBVar00346468 | |||||||||
| WBVar02128578 | |||||||||
| WBVar02128579 | |||||||||
| WBVar00346469 | |||||||||
| WBVar02128580 | |||||||||
| WBVar00346470 | |||||||||
| WBVar00346471 | |||||||||
| WBVar00346472 | |||||||||
| WBVar00346473 | |||||||||
| WBVar00346474 | |||||||||
| WBVar00346475 | |||||||||
| WBVar00346476 | |||||||||
| WBVar00157578 | |||||||||
| WBVar00346477 | |||||||||
| WBVar00346478 | |||||||||
| WBVar00157579 | |||||||||
| WBVar00157580 | |||||||||
| WBVar00346479 | |||||||||
| WBVar00157581 | |||||||||
| WBVar00321411 | |||||||||
| WBVar00157582 | |||||||||
| WBVar00157583 | |||||||||
| WBVar00157584 | |||||||||
| WBVar00157585 | |||||||||
| WBVar01713358 | |||||||||
| WBVar00157586 | |||||||||
| WBVar00157587 | |||||||||
| WBVar01713359 | |||||||||
| WBVar01713360 | |||||||||
| WBVar01713361 | |||||||||
| WBVar02147403 | |||||||||
| WBVar01392182 | |||||||||
| WBVar01532283 | |||||||||
| WBVar01499788 | |||||||||
| WBVar01499054 | |||||||||
| WBVar01988539 | |||||||||
| WBVar02083890 | |||||||||
| WBVar01801377 | |||||||||
| WBVar00539708 | |||||||||
| WBVar01957877 | |||||||||
| WBVar00539711 | |||||||||
| WBVar00673957 | |||||||||
| WBVar00673958 | |||||||||
| WBVar00673959 | |||||||||
| WBVar00673960 | |||||||||
| WBVar00673961 | |||||||||
| WBVar00673962 | |||||||||
| WBVar00673963 | |||||||||
| WBVar00673964 | |||||||||
| WBVar00673965 | |||||||||
| WBVar00673966 | |||||||||
| WBVar00673967 | |||||||||
| WBVar00673968 | |||||||||
| WBVar00673969 | |||||||||
| WBVar00673970 | |||||||||
| WBVar00673971 | |||||||||
| WBVar00673972 | |||||||||
| WBVar00673973 | |||||||||
| WBVar00673974 | |||||||||
| WBVar00673975 | |||||||||
| WBVar00673976 | |||||||||
| WBVar00673977 | |||||||||
| WBVar00673978 | |||||||||
| WBVar00673979 | |||||||||
| WBVar00673980 | |||||||||
| WBVar01932646 | |||||||||
| WBVar00673981 | |||||||||
| WBVar00673982 | |||||||||
| WBVar00673983 | |||||||||
| WBVar00673984 | |||||||||
| WBVar00673985 | |||||||||
| WBVar00673986 | |||||||||
| WBVar00673987 | |||||||||
| WBVar01433264 | |||||||||
| WBVar00673988 | |||||||||
| WBVar00673989 | |||||||||
| WBVar00673990 | |||||||||
| WBVar00673991 | |||||||||
| WBVar01411862 | |||||||||
| WBVar01890246 | |||||||||
| WBVar00673992 | |||||||||
| WBVar00673993 | |||||||||
| WBVar01411863 | |||||||||
| WBVar01285312 | |||||||||
| WBVar01411864 | |||||||||
| WBVar01285314 | |||||||||
| WBVar01285315 | |||||||||
| WBVar01285316 | |||||||||
| WBVar01285319 | |||||||||
| WBVar02145406 | |||||||||
| WBVar02145407 | |||||||||
| WBVar00319580 | |||||||||
| WBVar02125009 | |||||||||
| WBVar02145408 | |||||||||
| WBVar02016480 | |||||||||
| WBVar02016481 | |||||||||
| WBVar02033030 | |||||||||
| WBVar01498959 | |||||||||
| Strain | WBStrain00035504 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (48) | |||||||||
| Ortholog (49) | |||||||||
| Paralog | WBGene00000088 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000254 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001172 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00017686 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | kpc-1 encodes two isoforms of a Kex2/subtilisin-like proprotein convertase that is a member of the subtilase family of calcium-dependent serine endoproteinases that includes mammalian furin (OMIM:136950) and Saccharomyces cerevisiae Kex2p; KPC-1 is required for normal growth and locomotion and is likely responsible for the processing of transforming growth factor (TGF) beta proproteins encoded by daf-7, dbl-1, and unc-129. | Paper_evidence | WBPaper00004142 | |||||
| WBPaper00018607 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables serine-type endopeptidase activity and signaling receptor binding activity. Involved in several processes, including neuron development; positive regulation of developmental process; and protein processing. Located in neuronal cell body. Expressed in several structures, including PVD; epithelial cell; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in arteriosclerosis; colon adenocarcinoma; and colorectal adenocarcinoma. Is an ortholog of human FURIN (furin, paired basic amino acid cleaving enzyme). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:234 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8747) | ||||
| DOID:2349 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8568) | ||||||
| DOID:0050861 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8746) | ||||||
| Molecular_info | Corresponding_CDS | F11A6.1a | |||||||
| Corresponding_CDS_history | F11A6.1b:wp245 | ||||||||
| Corresponding_transcript | F11A6.1b | ||||||||
| F11A6.1a.1 | |||||||||
| F11A6.1a.2 | |||||||||
| Other_sequence (36) | |||||||||
| Associated_feature (22) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00116836 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00003363 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089035 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00106792 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00044358 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027714 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00018109 | ||||||||
| WBCnstr00018110 | |||||||||
| WBCnstr00020063 | |||||||||
| Construct_product | WBCnstr00018110 | ||||||||
| WBCnstr00018228 | |||||||||
| WBCnstr00019277 | |||||||||
| WBCnstr00043014 | |||||||||
| Microarray_results (39) | |||||||||
| Expression_cluster (198) | |||||||||
| Interaction (29) | |||||||||
| Map_info | Map | I | Position | 9.53611 | Error | 0.019245 | |||
| Positive | Positive_clone | F11A6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4460 | |||||||
| 4467 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (28) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
