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WormBase Tree Display for Gene: WBGene00006843

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Name Class

WBGene00006843SMapS_parentSequenceCHROMOSOME_III
IdentityVersion1
NameCGC_nameunc-119Person_evidenceWBPerson261
Sequence_nameM142.1
Molecular_nameM142.1a
M142.1a.1
CE06203
M142.1b
CE43523
M142.1c
CE44343
M142.1b.1
M142.1c.1
Other_name3L997Inferred_automatically
CELE_M142.1Accession_evidenceNDBBX284603
Public_nameunc-119
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:43WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Allele (132)
Possibly_affected_byWBVar02152819
WBVar02153069
WBVar02153167
WBVar02153169
WBVar02153170
WBVar02153171
WBVar02153173
WBVar02154063
WBVar02158600
WBVar02158612
Legacy_informationSee also e2498
[Maduro & Pilgrim] e2498::Tc1: strong unc, almost paralyzed adults, dumpyish, tends to curl; daf-d (daf-7 suppressible), weak FITC uptake; partially Egl; similar phenotype to eDf2; eDp6. ES3 (all stages), ME0. NA4 (ed3op, ed4oc, ed9: all similar to e2498, all putative nulls). Ref. DP.
[C.elegansII] e2498::Tc1 : severe Unc, almost paralysed adults,dumpyish, tends to curl; Daf-d, partial Egl, partial Dyf. Normal muscle ultrastructure.ES3. ME0. OA3: ed3op, ed4oc, ed9 (all similar). Cloned: encodes predicted 219 aa novel protein. unc-119:GFP expressed extensively in axons. [Maduro & Pilgrim 1995]
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RNASeq_FPKM (74)
GO_annotation (22)
Ortholog (38)
ParalogWBGene00003966Caenorhabditis elegansFrom_analysisTreeFam
Structured_descriptionConcise_descriptionunc-119 encodes a novel protein that is highly conserved amongst metazoans; unc-119 activity is required for proper development of the nervous system, including axonal branching and fasciculation, and hence, for normal movement, chemosensation, and feeding; unc-119 is expressed pan-neuronally beginning in the early embryo (~60 cells) and continuing through adulthood; although the molecular function of UNC-119 is not yet known, human UNC119, which can rescue C. elegans unc-119 mutant animals, is reported to function as a receptor-associated activator of signal transduction; thus, UNC-119 may be part of a signal transduction pathway that mediates axonal patterning in response to external developmental cues.Paper_evidenceWBPaper00002306
WBPaper00003926
WBPaper00024591
Curator_confirmedWBPerson1843
Date_last_updated15 Dec 2004 00:00:00
Automated_descriptionPredicted to enable lipid binding activity. Involved in several processes, including body morphogenesis; dauer larval development; and regulation of multicellular organismal process. Located in axon. Expressed in several structures, including body wall musculature; ganglia; neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in cone-rod dystrophy and immunodeficiency 13. Is an ortholog of human UNC119 (unc-119 lipid binding chaperone) and UNC119B (unc-119 lipid binding chaperone B).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0111987Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12565)
DOID:0050572Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12565)
Molecular_infoCorresponding_CDSM142.1a
M142.1b
M142.1c
Corresponding_transcriptM142.1a.1
M142.1b.1
M142.1c.1
Other_sequence (63)
Associated_featureWBsf645591
WBsf645592
WBsf659551
WBsf659552
WBsf659553
WBsf994184
WBsf994185
WBsf994186
WBsf1015873
WBsf225774
WBsf225775
WBsf225776
Experimental_infoRNAi_result (13)
Expr_pattern (18)
Drives_construct (109)
Construct_product (41)
AntibodyWBAntibody00000421
WBAntibody00002511
WBAntibody00002695
Microarray_results (21)
Expression_cluster (150)
Interaction (303)
Map_infoMapIIIPosition5.58925Error0.00446
Well_ordered
PositivePositive_cloneC27F7
C44B9
M142Inferred_automaticallyFrom sequence, transcript, pseudogene data
Y39A1
Y60D9
NegativeNegative_cloneK02B6
K11D9
T27G1
Mapping_data2_point4972
4973
4974
Multi_point1715
1716
1717
Pos_neg_data4970
4971
Reference (258)
Remarka sequence search shows strong similarity to C27H5.1 (II): a 92 a.a. region shows 26% identity, 51% similarity to UNC-119.
MethodGene