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WormBase Tree Display for Gene: WBGene00006812

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Name Class

WBGene00006812SMapS_parentSequenceF25C8
IdentityVersion2
NameCGC_nameunc-80Person_evidenceWBPerson261
Sequence_nameF25C8.3
Molecular_name (15)
Other_nameCELE_F25C8.3Accession_evidenceNDBBX284605
Public_nameunc-80
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:43WBPerson1971EventImportedInitial conversion from geneace
213 Nov 2007 10:02:04WBPerson2970EventAcquires_mergeWBGene00009105
Acquires_mergeWBGene00009105
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Reference_alleleWBVar00143879
AlleleWBVar00143720Inferred_automaticallyFrom strain object: CB1069
WBVar00239133Inferred_automaticallyFrom strain object: XA3702
WBVar00145324
WBVar00145325
WBVar00145321
WBVar02147657
WBVar02147655
WBVar02147654
WBVar02147656
WBVar02150637
WBVar01110289
WBVar01756952
WBVar00095024
WBVar01110290
WBVar00095025
WBVar01756953
WBVar01110291
WBVar01756954
WBVar01110292
WBVar01110293
WBVar00601023
WBVar01110294
WBVar01110295
WBVar01110296
WBVar01110297
WBVar01110298
WBVar01110299
WBVar01110300
WBVar01110301
WBVar01110302
WBVar01110303
WBVar01110304
WBVar01110305
WBVar01110306
WBVar01110307
WBVar01110308
WBVar00491423
WBVar00491424
WBVar01110309
WBVar00491425
WBVar01110310
WBVar01110311
WBVar00491426
WBVar00491427
WBVar01110312
WBVar00229356
WBVar00491428
WBVar01110313
WBVar01110314
WBVar01498436
WBVar00229360
WBVar00491429
WBVar01110315
WBVar00491430
WBVar01110316
WBVar00491431
WBVar01110317
WBVar00491432
WBVar00491433
WBVar01110318
WBVar00491434
WBVar00093867
WBVar01110319
WBVar02026534
WBVar01110320
WBVar02026535
WBVar00491435
WBVar02026536
WBVar00491436
WBVar01110321
WBVar02026537
WBVar00491437
WBVar01110322
WBVar01110323
WBVar02026538
WBVar00491438
WBVar02026539
WBVar01110324
WBVar00491439
WBVar01499184
WBVar02138525
WBVar02026540
WBVar01110325
WBVar00491440
WBVar01110326
WBVar00491441
WBVar02026541
WBVar00491442
WBVar01110327
WBVar00491443
WBVar01110328
WBVar01110329
WBVar00491444
WBVar01110330
WBVar00491445
WBVar01110331
WBVar00491446
WBVar01829929
WBVar00491447
WBVar01110332
WBVar01829930
WBVar01110333
WBVar01829931
WBVar00491448
WBVar01110334
WBVar00491449
WBVar00491450
WBVar01110335
WBVar01978836
WBVar01110336
WBVar00491451
WBVar02044299
WBVar01941362
WBVar01110337
WBVar00491452
WBVar00491453
WBVar01110338
WBVar01941363
WBVar00491454
WBVar01110339
WBVar00491455
WBVar01110340
WBVar01678825
WBVar00491456
WBVar01678826
WBVar01110341
WBVar00491457
WBVar01678827
WBVar01110342
WBVar00491458
WBVar01678828
WBVar00491459
WBVar01878003
WBVar00491460
WBVar00491461
WBVar01878004
WBVar00491462
WBVar01878005
WBVar01878006
WBVar00491463
WBVar00491464
WBVar00491465
WBVar00603331
WBVar00603332
WBVar00603333
WBVar00603334
WBVar00074017
WBVar00074018
WBVar00074019
WBVar00143879
WBVar00074020
WBVar00074021
WBVar00074022
WBVar01110190
WBVar00313463
WBVar00074023
WBVar01110191
WBVar00074024
WBVar01110192
WBVar00074025
WBVar00074026
WBVar01110193
WBVar01600071
WBVar00074027
WBVar01600072
WBVar01110194
WBVar00074028
WBVar01110195
WBVar01600073
WBVar00074029
WBVar01600074
WBVar01110196
WBVar01600075
WBVar00074030
WBVar01110197
WBVar01110198
WBVar01600076
WBVar01110199
WBVar01110200
WBVar01110201
WBVar01110202
WBVar01786793
WBVar01110203
WBVar01110204
WBVar01110205
WBVar01110206
WBVar01110207
WBVar01110208
WBVar01110209
WBVar01110210
WBVar01110211
WBVar01110212
WBVar01110213
WBVar01110214
WBVar01110215
WBVar02147969
WBVar01110216
WBVar01110217
WBVar01110218
WBVar01499446
WBVar01110219
WBVar01110220
WBVar01926696
WBVar01110221
WBVar01500000
WBVar01110222
WBVar01110223
WBVar01110224
WBVar01110225
WBVar01110226
WBVar01526427
WBVar01110227
WBVar01526428
WBVar01110228
WBVar01526429
WBVar01526430
WBVar01110229
WBVar01526431
WBVar01110230
WBVar01110231
WBVar01110232
WBVar01110233
WBVar01110234
WBVar01110235
WBVar01110236
WBVar01110237
WBVar01110238
WBVar01498729
WBVar01110239
WBVar01110240
WBVar01110241
WBVar01110242
WBVar01110243
WBVar01498549
WBVar01110244
WBVar01110245
WBVar01110246
WBVar01110247
WBVar01110248
WBVar01110249
WBVar01110250
WBVar01110251
WBVar01110252
WBVar01110253
WBVar01110254
WBVar01822243
WBVar01110255
WBVar01499299
WBVar01110256
WBVar01110257
WBVar01110258
WBVar01110259
WBVar01110260
WBVar01110261
WBVar01110262
WBVar01110263
WBVar01110264
WBVar01110265
WBVar01110266
WBVar01110267
WBVar01756930
WBVar01486061
WBVar02074500
WBVar02074501
WBVar01110268
WBVar01756931
WBVar01110269
WBVar01756932
WBVar01110270
WBVar01756933
WBVar01110271
WBVar01756934
WBVar01110272
WBVar01756935
WBVar01110273
WBVar01544418
WBVar01756936
WBVar01756937
WBVar01110274
WBVar01544419
WBVar01756938
WBVar01544420
WBVar01110275
WBVar01914168
WBVar01110276
WBVar01756939
WBVar01544421
WBVar01756940
WBVar01914169
WBVar01110277
WBVar01756941
WBVar01110278
WBVar01756942
WBVar01110279
WBVar01110280
WBVar01756943
WBVar01756944
WBVar01110281
WBVar01756945
WBVar01110282
WBVar01756946
WBVar01110283
WBVar01894562
WBVar00095019
WBVar01756947
WBVar01110284
WBVar01110285
WBVar01756948
WBVar01756949
WBVar01110286
WBVar00095022
WBVar01756950
WBVar01110287
WBVar00095023
WBVar01110288
WBVar01756951
Legacy_informatione1272 : slightly sluggish tends to pause good movement. ES1 ME3. NA2 (e1069).
See also e1069, e1272
[C.elegansII] e1272 : slightly sluggish, tends to pause ("fainter"), good movement; hypersensitive to volatile anaesthetics.ES1 ME3. OA2: e1069, m513. [Sedensky and Meneely 1987; Morgan et al. 1991; CW]
StrainWBStrain00032777
WBStrain00040621
WBStrain00004238
WBStrain00004286
RNASeq_FPKM (74)
GO_annotation (15)
Ortholog (35)
Structured_descriptionConcise_descriptionunc-80 encodes a novel protein, conserved amongst C. elegans, Drosophila, and vertebrates; unc-79 functions in a pathway with unc-77 and nca-2, which encode alpha-1 subunits of voltage-insensitive cation leak channels, to regulate presynaptic activation and thus, locomotion and the response to specific volatile anesthetics; co-expression of UNC-77 and UNC-80 in HEK293T cells results in increased UNC-77 channel activity, in a manner consistent with UNC-77 and UNC-80 functioning as an ion leak channel; an unc-80::gfp reporter fusion is expressed in many sensory and all motoneurons; in the nerve ring and in dorsal and ventral nerve cords, UNC-80 localizes to specific axonal regions, but not to synapses; UNC-80, UNC-77, and UNC-79, an additional novel protein believed to act in the same pathway, reciprocally regulate their expression levels in neurons.Paper_evidenceWBPaper00001281
WBPaper00031000
WBPaper00031592
Curator_confirmedWBPerson1843
Date_last_updated22 Jun 2010 00:00:00
Automated_descriptionEnables monoatomic cation channel activity. Involved in several processes, including monoatomic cation homeostasis; positive regulation of locomotion; and response to anesthetic. Located in axon. Part of cation channel complex. Expressed in excretory canal; hermaphrodite distal tip cell; nervous system; and non-striated muscle. Is an ortholog of human UNC80 (unc-80 homolog, NALCN channel complex subunit).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelEFO:MONDO:0014176Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:26582)
Molecular_infoCorresponding_CDSF25C8.3a
F25C8.3b
F25C8.3c
F25C8.3d
F25C8.3e
Corresponding_CDS_historyF25C8.3:wp87
F25C8.3:wp109
F25C8.3a:wp182
Corresponding_transcriptF25C8.3a.1
F25C8.3b.1
F25C8.3c.1
F25C8.3d.1
F25C8.3e.1
Other_sequence (25)
Associated_featureWBsf647771
WBsf662284
WBsf662285
WBsf662286
WBsf1003660
WBsf1003661
WBsf1003662
WBsf1022024
WBsf1022025
WBsf1022026
Experimental_infoRNAi_result (12)
Expr_patternExpr4994
Expr8059
Expr8061
Expr16166
Expr1026757
Expr1032878
Expr1149400
Expr2017910
Expr2036046
Drives_constructWBCnstr00000610
WBCnstr00001622
WBCnstr00013085
WBCnstr00042790
Construct_productWBCnstr00000610
Microarray_results (26)
Expression_clusterWBPaper00024970:GABAergic_neuron_specific
WBPaper00031040:TGF-beta_adult_upregulated
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037055:DAF-16_binding_DNA
WBPaper00037950:A-class-motor-neurons_larva_enriched
WBPaper00037950:all-neurons_embryo_enriched
WBPaper00037950:AVA-neuron_embryo_enriched
WBPaper00037950:AVE-neuron_embryo_enriched
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:dopaminergic-neurons_embryo_enriched
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_embryo_enriched
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00042215:wdr-23(tm1817)_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00045521:Oogenic
WBPaper00046795:starvation_upregulated
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00049545:cco-1(RNAi)_downregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050496:unc-39(hp701)_regulated
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051404:alg-2(ok304)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053295:lin-22(icb38)_upregulated
WBPaper00053295:lin-22(ot267)_upregulated
WBPaper00053295:lin-22(ot269)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053814:15C_downregulated_OP50
WBPaper00054493:hpl-2(tm1489)_upregulated
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055103:thoc-5(wy822)_upregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055565:AVK_enriched
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056284:ints-5(RNAi)_upregulated
WBPaper00056443:DietaryRestriction_downregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056809:smn-1(ok355)_upregulated
WBPaper00056826:hmc_biased
WBPaper00057288:iff-1(RNAi)_upregulated_transcript
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058711:wdr-5(ok1417)_upregulated
WBPaper00058942:henn-1(pk2295)_upregulated
WBPaper00058969:RIS_enriched
WBPaper00059027:neuron-synapses_depleted
WBPaper00059471:EGL-43_interacting
WBPaper00059566:wdr-23(mac32)_upregulated
WBPaper00059567:olrn-1(ums9)_regulated
WBPaper00059763:neuron_expressed
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061340:ALA
WBPaper00061340:AVA
WBPaper00061340:AVB
WBPaper00061340:AVE
WBPaper00061340:AVG
WBPaper00061340:AVH
WBPaper00061340:AVK
WBPaper00061340:AVL
WBPaper00061340:DA
WBPaper00061340:DA_DB
WBPaper00061340:DB
WBPaper00061340:DD
WBPaper00061340:DVA
WBPaper00061340:DVC
WBPaper00061340:hmc
WBPaper00061340:OLL
WBPaper00061340:OLQ
WBPaper00061340:PVR
WBPaper00061340:RIB
WBPaper00061340:RIC
WBPaper00061340:RIH
WBPaper00061340:RIM
WBPaper00061340:RIS
WBPaper00061340:RIV
WBPaper00061340:SMD
WBPaper00061340:Y
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061439:unc-30(ok613)_downregulated
WBPaper00061466:nath-10(icb99)_downregulated
WBPaper00061466:nath-10(icb102)_downregulated
WBPaper00061479:mep-1(ne4629)_upregulated
WBPaper00061527:sol-1-jnk-1_18695
WBPaper00061651:AS_enriched
WBPaper00061651:AVA_enriched
WBPaper00061651:AVL_enriched
WBPaper00061651:DA9_enriched
WBPaper00061651:DA_enriched
WBPaper00061651:DB01_enriched
WBPaper00061651:DB_enriched
WBPaper00061651:I1_enriched
WBPaper00061651:LUA_enriched
WBPaper00061651:PDA_enriched
WBPaper00061651:PDB_enriched
WBPaper00061651:PHC_enriched
WBPaper00061651:RIB_enriched
WBPaper00061651:RMD_DV_enriched
WBPaper00061651:SAB_enriched
WBPaper00061651:VA12_enriched
WBPaper00061651:VA_enriched
WBPaper00061651:VB_enriched
WBPaper00061753:csr-1(tor159)_downregulated_20C
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062103:neuron_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064156:lbp-3(overexpress)_upregulated
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
WBPaper00064532:pals-25(icb98)_upregulated
WBPaper00064721:fasn-1(g14)_downregulated_starved
WBPaper00064871:hypoxia_downregulated_F1
WBPaper00064939:vit-5(RNAi)_upregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065623:80
WBPaper00065749:Heat-Shock_downregulated_N2
WBPaper00065841:14_2
WBPaper00065841:52_0
WBPaper00065841:61_0
WBPaper00065841:68_0
WBPaper00065841:100_0
WBPaper00065841:108_0
WBPaper00065841:132_0
WBPaper00065841:134_0
WBPaper00065841:136_0
WBPaper00065841:140_0
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066110:tetraploid_vs_diploid_upregulated
cgc4489_group_20
WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Enriched_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00030839:Embryo_A_Class
WBPaper00030839:Embryo_Pan_Neuronal
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00030985:Enterococcus_faecalis_upregulated
WBPaper00030985:Photorhabdus_luminescens_upregulated
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:hlh_1_enriched
WBPaper00031003:total_muscle_depleted
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00032165:differentially_expressed_with_age_medoid_1
WBPaper00032948:StarveUp1
WBPaper00034661:AgNPs_downregulated
WBPaper00036286:Pattern_C
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040823:alg-1(gk214)_downregulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00042548:miRISC_enriched
WBPaper00045263:isp-1(qm150)_upregulated
WBPaper00047070:N2_starvation_upregulated
WBPaper00047070:xpa-1_UV_downregulated
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc6390]:Cluster_A
Interaction (41)
Map_infoMapVPosition25.581Error0.021198
PositivePositive_cloneF25C8Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point1568
Reference (46)
MethodGene