WormBase Tree Display for Gene: WBGene00000053

WBGene00000053 SMap: S_parent: Sequence: T05C12
  Identity: Version: 1
    Name: CGC_name: acr-14 Person_evidence: WBPerson1430
      Sequence_name: T05C12.2
      Molecular_name: T05C12.2
        T05C12.2.1
        CE25099
      Other_name: CELE_T05C12.2 Accession_evidence: NDB BX284602
      Public_name: acr-14
    DB_info: Database (9)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:19 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: acr
    Allele (30)
    Strain: WBStrain00031836
    RNASeq_FPKM (74)
    GO_annotation (28)
    Ortholog (36)
    Paralog: WBGene00000042 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000043 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000044 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000045 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000046 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000047 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000048 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000049 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000050 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000051 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00006784 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001586 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001587 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001588 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000233 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002974 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00006765 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006774 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000951 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001133 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00006797 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001591 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001592 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001593 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008280 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009799 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00010275 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00010741 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018880 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000058 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001512 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000060 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000055 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000061 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000955 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00002975 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00017580 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000056 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00043066 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000059 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00019069 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00015412 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00022247 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000054 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00020048 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00017375 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00010994 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00021981 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000057 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00012857 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000062 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00013534 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00008997 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00020836 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017389 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008551 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000845 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007903 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007191 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022283 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011360 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011359 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011358 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013655 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011356 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011355 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020236 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011354 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00045385 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007594 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00044301 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017543 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017544 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013338 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013300 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020528 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013517 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000232 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020767 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00021146 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022106 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008223 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020657 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013746 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008076 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008022 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017314 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00021437 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009790 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003386 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020605 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001594 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017399 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020569 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012099 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013914 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001373 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012915 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017483 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00044528 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: acr-14 encodes a protein that contains neurotransmitter-gated ion-channel ligand-binding and transmembrane domains. Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in excitatory postsynaptic potential and monoatomic ion transmembrane transport. Predicted to be located in neuron projection and synapse. Expressed in intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lewy body dementia; carcinoma (multiple); and inflammatory bowel disease (multiple). Is an ortholog of human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:3748 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:8778 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:3083 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:12217 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:8577 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:1324 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:7474 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:5419 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
  Molecular_info: Corresponding_CDS: T05C12.2
    Corresponding_transcript: T05C12.2.1
    Other_sequence: JI180092.1
    Associated_feature: WBsf223455
      WBsf223456
  Experimental_info: RNAi_result: WBRNAi00066388 Inferred_automatically: RNAi_primary
      WBRNAi00097922 Inferred_automatically: RNAi_primary
      WBRNAi00052489 Inferred_automatically: RNAi_primary
      WBRNAi00018218 Inferred_automatically: RNAi_primary
      WBRNAi00078345 Inferred_automatically: RNAi_primary
      WBRNAi00035191 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1906
      Expr4858
      Expr8203
      Expr10607
      Expr13428
      Expr1018728
      Expr1156115
      Expr2009181
      Expr2027420
    Drives_construct (11)
    Construct_product: WBCnstr00016680
      WBCnstr00037766
    Microarray_results (20)
    Expression_cluster: WBPaper00024970:GABAergic_neuron_specific
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:A-class-motor-neurons_larva_SelectivelyEnriched
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_larva_enriched
      WBPaper00037950:all-neurons_larva_SelectivelyEnriched
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_CoreEnriched
      WBPaper00037950:GABAergic-motor-neurons_embryo_enriched
      WBPaper00037950:GABAergic-motor-neurons_embryo_SelectivelyEnriched
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_larva_enriched
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00042477:rsr-2(RNAi)_downregulated_TilingArray
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00048988:neuron_expressed
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059763:neuron_expressed
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00061340:AMso
      WBPaper00061340:AVA
      WBPaper00061340:AVE
      WBPaper00061340:AVJ
      WBPaper00061340:DA
      WBPaper00061340:DA_DB
      WBPaper00061340:DD
      WBPaper00061340:DVA
      WBPaper00061340:Parents_of_Y_DA6_DA7_DA9
      WBPaper00061340:Pharyngeal_intestinal_valve
      WBPaper00061340:SMB
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061527:ckr-1-T09B9.3
      WBPaper00061651:AS_enriched
      WBPaper00061651:SAB_enriched
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium
      WBPaper00064716:paraquat_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065841:6_0
      WBPaper00065841:6_2
      WBPaper00065841:10_0
      WBPaper00065841:14_0
      WBPaper00065841:14_1
      WBPaper00065841:14_2
      WBPaper00065841:50_0
      WBPaper00065841:56_0
      WBPaper00065841:61_0
      WBPaper00065841:98_0
      WBPaper00065841:117_0
      WBPaper00065841:119_0
      WBPaper00065841:132_0
      WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
      WBPaper00005124:testosterone_10-9M_regulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00030839:Embryo_A_Class
      WBPaper00030839:Larval_A_Class
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00042548:miRISC_enriched
      WBPaper00045673:colistin_upregulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
    Interaction (28)
  Map_info: Map: II Position: 0.742235 Error: 0.001179
    Positive: Positive_clone: T05C12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4965
        4646
        5546
    Pseudo_map_position
  Reference (26)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene