e211 (pka tmr-1) : almost normal movement in absence of drug uncoordinated but not hypercontracted in 1 mM levamisole. ES2. ME3. NA > 10 (x22 etc.). Also two rare semidominant alleles with uncoordinated phenotype x21 : (uncoordinated Egl-c ME3) x63.
See also e211, e289
[C.elegansII] e211 : (pka tmr-1) almost normal movement in absence of drug uncoordinated but not hypercontracted in 1 mM levamisole. ES2. ME3. OA>10: x22, e289, x577 etc. Also two rare semidominant alleles with uncoordinated phenotype, x21 (uncoordinated Egl-c, ME3), x63. Cloned: corresponds to acr-1, encoding subunit of nicotinic acetylcholine receptor. [Lewis et al. 1980, 1987; ZZ; MQ]
lev-1 encodes a non-alpha subunit of nicotinic acetylcholine receptor (nAChR) which, when mutated, confers resistance to levamisole; LEV-1 is required for completely normal locomotion, regulation of egg-laying behavior, and forms a cation channel when coexpressed with UNC-38 or UNC-63 and UNC-29; LEV-1 falls into the 'UNC-29' class of nAChR subunits, which includes UNC-29, ACR-2, and ACR-3; a LEV-1::GFP fusion protein is expressed in all body wall muscle cells and a subset of ventral cord motor neurons.
Enables acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Involved in regulation of egg-laying behavior; regulation of locomotion; and transmembrane transport. Located in neuron projection; neuronal cell body; and postsynaptic membrane. Expressed in body wall musculature; dorsal nerve cord; nerve ring; ventral cord neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including congenital myasthenic syndrome (multiple); lung disease (multiple); and nicotine dependence. Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).