WormBase Tree Display for Gene: WBGene00006784

WBGene00006784 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: T21C12
  Identity: Version: 1
    Name: CGC_name: unc-49 Person_evidence: WBPerson261
      Sequence_name: T21C12.1
      Molecular_name (40)
      Other_name: unc-49A Accession_evidence: EMBL AF151640
        unc-49B Accession_evidence: EMBL AF151641
        unc-49C Accession_evidence: EMBL AF151644
        CELE_T21C12.1 Accession_evidence: NDB BX284603
      Public_name: unc-49
    DB_info: Database: AceView gene 3L621
        WormQTL gene WBGene00006784
        WormFlux gene WBGene00006784
        NDB locus_tag CELE_T21C12.1
        Panther gene CAEEL|WormBase=WBGene00006784|UniProtKB=G5ECD3
          family PTHR18945
        NCBI gene 176472
        RefSeq protein (13)
        TrEMBL UniProtAcc (13)
        UniProt_GCRP UniProtAcc G5ECD3
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143164
    Allele: WBVar00090125 Inferred_automatically: From strain object: MT3123
      WBVar00090137 Inferred_automatically: From strain object: MT3123
      WBVar00143609
      WBVar00143339
      WBVar00090126
      WBVar00090457
      WBVar00407500
      WBVar00407501
      WBVar00407502
      WBVar00407503
      WBVar00306688
      WBVar01578966
      WBVar00306689
      WBVar00407504
      WBVar02019136
      WBVar01578967
      WBVar00407505
      WBVar00306690
      WBVar00407506
      WBVar00407507
      WBVar01500260
      WBVar00407508
      WBVar00407509
      WBVar00407510
      WBVar00407511
      WBVar00407512
      WBVar00407513
      WBVar00407514
      WBVar00407515
      WBVar00322197
      WBVar00216532
      WBVar00407516
      WBVar00216533
      WBVar00407517
      WBVar00216534
      WBVar00407518
      WBVar00216536
      WBVar00407519
      WBVar00407520
      WBVar00216538
      WBVar00216539
      WBVar00407521
      WBVar00407522
      WBVar00407523
      WBVar02012966
      WBVar00407524
      WBVar00407525
      WBVar00407526
      WBVar00407527
      WBVar00600869
      WBVar01944724
      WBVar01499194
      WBVar00258414
      WBVar01397292
      WBVar01397293
      WBVar01397294
      WBVar01918801
      WBVar01963029
      WBVar01963030
      WBVar00856988
      WBVar01963031
      WBVar01963032
      WBVar00856989
      WBVar00856990
      WBVar00856991
      WBVar01567387
      WBVar00856992
      WBVar00237136
      WBVar00178765
      WBVar00856993
      WBVar00178766
      WBVar01567388
      WBVar00856994
      WBVar00178767
      WBVar01567389
      WBVar02132662
      WBVar00178769
      WBVar01567390
      WBVar00856995
      WBVar01567391
      WBVar00856996
      WBVar00178770
      WBVar00258433
      WBVar01567392
      WBVar00178771
      WBVar00856997
      WBVar00856998
      WBVar00178772
      WBVar00178773
      WBVar01499774
      WBVar00856999
      WBVar00178775
      WBVar00857000
      WBVar00178776
      WBVar00857001
      WBVar00178777
      WBVar00857002
      WBVar00297315
      WBVar00857003
      WBVar00178778
      WBVar01499594
      WBVar00857004
      WBVar00297316
      WBVar01499595
      WBVar00297317
      WBVar00857005
      WBVar00857006
      WBVar00857007
      WBVar00857008
      WBVar00598659
      WBVar00857009
      WBVar00857010
      WBVar00857011
      WBVar00090456
      WBVar00857012
      WBVar00857013
      WBVar01542281
      WBVar00269989
      WBVar00857014
      WBVar01542283
      WBVar00857015
      WBVar00269992
      WBVar00857016
      WBVar01542284
      WBVar00857017
      WBVar00857018
      WBVar00857019
      WBVar02048084
      WBVar00857020
      WBVar00857021
      WBVar00857022
      WBVar00857023
      WBVar00857024
      WBVar00857025
      WBVar00857026
      WBVar00857027
      WBVar00857028
      WBVar00857029
      WBVar00857030
      WBVar00857031
      WBVar00857032
      WBVar00299870
      WBVar00299871
      WBVar00857033
      WBVar00299872
      WBVar00857034
      WBVar00299873
      WBVar00857035
      WBVar00857036
      WBVar00857037
      WBVar00857038
      WBVar00857039
      WBVar00857040
      WBVar00857041
      WBVar00857042
      WBVar00234058
      WBVar00857043
      WBVar00857044
      WBVar00857045
      WBVar00857046
      WBVar00857047
      WBVar00857048
      WBVar00857049
      WBVar00240576
      WBVar00857050
      WBVar00857051
      WBVar00240578
      WBVar00857052
      WBVar00857053
      WBVar00143164
      WBVar00857054
      WBVar00857055
      WBVar00857056
      WBVar00857057
      WBVar00857058
      WBVar00857059
      WBVar00101277
      WBVar00857060
      WBVar01480330
      WBVar01480331
      WBVar00101278
      WBVar00857061
      WBVar00857062
      WBVar00143186
      WBVar00857063
      WBVar00857064
      WBVar00857065
      WBVar01409287
      WBVar01409288
      WBVar01267964
      WBVar00143236
      WBVar01267969
      WBVar01267972
      WBVar01267974
      WBVar01267978
      WBVar02052421
      WBVar01267979
      WBVar01267981
      WBVar01267983
      WBVar01448122
      WBVar01448123
      WBVar01448124
      WBVar01448125
      WBVar00143362
      WBVar01448128
      WBVar01904189
      WBVar00309013
      WBVar00309014
      WBVar00309015
      WBVar01333011
      WBVar01333016
      WBVar01492883
      WBVar01939766
      WBVar00407496
      WBVar01939767
      WBVar00407497
      WBVar01939768
      WBVar00407498
      WBVar01939769
      WBVar00407499
    Legacy_information: e382 : shrinker contracts both dorsally and ventrally when prodded slow poor backing slightly small. ES3 ME2. NA6 (e407 e468).
      See also e641, n1324
      [C.elegansII] e382 : shrinker, contracts both dorsally and ventrally when prodded; slow; poor backing, slightly small. Probable defect in inhibitory GABA receptor function. ES3 ME2. OA>5: e407, e468, e929, n1324 etc. Cloned: encodes predicted GABA-A receptor. In probable operon with two other GABA receptor subunits. [Brenner 1974; McIntire et al. 1993; EG; MT]
    Strain (14)
    Component_of_genotype: WBGenotype00000119
    RNASeq_FPKM (74)
    GO_annotation (28)
    Ortholog (37)
    Paralog (100)
    Structured_description: Concise_description: unc-49 encodes multiple subunits of a heteromeric GABA receptor; unc-49 activity is required for postsynaptic GABA responsiveness and thus for normal regulation of locomotion; UNC-49::GFP reporter fusions for at least two isoforms are expressed in dorsal and ventral head and body wall muscles, with isoform-specific expression also seen in the sphincter muscle; UNC-49::GFP subcellular localization is most prominent at neuromuscular junctions; in Xenopus oocytes and mammalian tissue culture cells, two UNC-49 subunits, UNC-49B and UNC-49C, are able to form a functional heteromeric GABA receptor. Paper_evidence: WBPaper00003576
          Curator_confirmed: WBPerson1843
          Date_last_updated: 24 Aug 2007 00:00:00
      Automated_description: Predicted to enable transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to chloride channel activity. Involved in gamma-aminobutyric acid signaling pathway; locomotory behavior; and regulation of backward locomotion. Located in neuromuscular junction and postsynaptic membrane. Expressed in AVA; anal sphincter muscle; body wall musculature; and somatic nervous system. Used to study epilepsy. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1826 Homo sapiens Paper_evidence: WBPaper00060194
          Curator_confirmed: WBPerson324
          Date_last_updated: 18 May 2022 00:00:00
  Models_disease_asserted: WBDOannot00001202
    WBDOannot00001203
  Molecular_info: Corresponding_CDS (13)
    Corresponding_CDS_history: T21C12.1a:wp227
      T21C12.1a:wp239
      T21C12.1g:wp275
    Corresponding_transcript (14)
    Other_sequence (51)
    Associated_feature (25)
  Experimental_info: RNAi_result: WBRNAi00090257 Inferred_automatically: RNAi_primary
      WBRNAi00053708 Inferred_automatically: RNAi_primary
      WBRNAi00089728 Inferred_automatically: RNAi_primary
      WBRNAi00066348 Inferred_automatically: RNAi_primary
      WBRNAi00027895 Inferred_automatically: RNAi_primary
      WBRNAi00000954 Inferred_automatically: RNAi_primary
      WBRNAi00090099 Inferred_automatically: RNAi_primary
      WBRNAi00018961 Inferred_automatically: RNAi_primary
      WBRNAi00089939 Inferred_automatically: RNAi_primary
      WBRNAi00006214 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1283
      Expr15907
      Expr1027570
      Expr1032855
      Expr1157259
      Expr1200291
      Expr2017881
      Expr2036017
      Marker2
      Marker19
    Drives_construct: WBCnstr00001626
      WBCnstr00001627
      WBCnstr00006881
      WBCnstr00010191
      WBCnstr00019381
      WBCnstr00020581
      WBCnstr00034153
      WBCnstr00042588
    Construct_product: WBCnstr00001627
      WBCnstr00006881
      WBCnstr00016180
      WBCnstr00019381
      WBCnstr00020010
      WBCnstr00020581
      WBCnstr00021428
      WBCnstr00034153
    Antibody: WBAntibody00000613
      WBAntibody00001987
    Microarray_results (88)
    Expression_cluster (187)
    Interaction (31)
    WBProcess: WBbiopr:00000010
  Map_info: Map: III Position: 3.35021 Error: 0.089636
    Well_ordered
    Positive: Inside_rearr: nDf40
        mT1
      Positive_clone: T21C12 Person_evidence: WBPerson39
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 73
        86
        589
        3249
      Multi_point (55)
      Pos_neg_data: 3242
        3250
        3251
  Reference (138)
  Remark: Sequence connection from [Bamber BA]
  Method: Gene