WormBase Tree Display for Gene: WBGene00006784

WBGene00006784 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: T21C12
  Identity: Version: 1
    Name: CGC_name: unc-49 Person_evidence: WBPerson261
      Sequence_name: T21C12.1
      Molecular_name (40)
      Other_name: unc-49A Accession_evidence: EMBL AF151640
        unc-49B Accession_evidence: EMBL AF151641
        unc-49C Accession_evidence: EMBL AF151644
        CELE_T21C12.1 Accession_evidence: NDB BX284603
      Public_name: unc-49
    DB_info: Database: AceView gene 3L621
        WormQTL gene WBGene00006784
        WormFlux gene WBGene00006784
        NDB locus_tag CELE_T21C12.1
        Panther gene CAEEL|WormBase=WBGene00006784|UniProtKB=G5ECD3
          family PTHR18945
        NCBI gene 176472
        RefSeq protein (13)
        TrEMBL UniProtAcc (13)
        UniProt_GCRP UniProtAcc G5ECD3
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143164
    Allele (220)
    Legacy_information: e382 : shrinker contracts both dorsally and ventrally when prodded slow poor backing slightly small. ES3 ME2. NA6 (e407 e468).
      See also e641, n1324
      [C.elegansII] e382 : shrinker, contracts both dorsally and ventrally when prodded; slow; poor backing, slightly small. Probable defect in inhibitory GABA receptor function. ES3 ME2. OA>5: e407, e468, e929, n1324 etc. Cloned: encodes predicted GABA-A receptor. In probable operon with two other GABA receptor subunits. [Brenner 1974; McIntire et al. 1993; EG; MT]
    Strain (14)
    Component_of_genotype: WBGenotype00000119
    RNASeq_FPKM (74)
    GO_annotation (28)
    Ortholog (37)
    Paralog: WBGene00000042 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000043 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000044 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000045 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000046 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000047 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000048 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000049 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000050 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000051 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000053 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000054 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000055 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000056 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000057 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000058 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000059 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000060 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000061 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000062 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000232 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000233 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000845 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000951 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000955 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001133 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001373 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001512 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001586 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001587 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001588 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001591 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001592 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001593 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001594 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002974 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002975 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003386 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006765 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006774 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008551 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00013914 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00020836 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017389 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00021981 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00010994 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007903 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007191 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022283 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006797 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00043066 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017580 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019069 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008997 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011360 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011359 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011358 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013655 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011356 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011355 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020236 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011354 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020048 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00015412 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00045385 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007594 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00044301 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017543 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017544 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017375 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012857 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013338 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013300 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022247 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013534 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020528 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013517 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020767 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00021146 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022106 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00010275 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008223 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00010741 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008280 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018880 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009799 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020657 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013746 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008076 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008022 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017314 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00021437 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009790 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020605 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017399 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020569 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012099 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012915 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017483 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00044528 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: unc-49 encodes multiple subunits of a heteromeric GABA receptor; unc-49 activity is required for postsynaptic GABA responsiveness and thus for normal regulation of locomotion; UNC-49::GFP reporter fusions for at least two isoforms are expressed in dorsal and ventral head and body wall muscles, with isoform-specific expression also seen in the sphincter muscle; UNC-49::GFP subcellular localization is most prominent at neuromuscular junctions; in Xenopus oocytes and mammalian tissue culture cells, two UNC-49 subunits, UNC-49B and UNC-49C, are able to form a functional heteromeric GABA receptor. Paper_evidence: WBPaper00003576
          Curator_confirmed: WBPerson1843
          Date_last_updated: 24 Aug 2007 00:00:00
      Automated_description: Predicted to enable transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to chloride channel activity. Involved in gamma-aminobutyric acid signaling pathway; locomotory behavior; and regulation of backward locomotion. Located in neuromuscular junction and postsynaptic membrane. Expressed in AVA; anal sphincter muscle; body wall musculature; and somatic nervous system. Used to study epilepsy. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1826 Homo sapiens Paper_evidence: WBPaper00060194
          Curator_confirmed: WBPerson324
          Date_last_updated: 18 May 2022 00:00:00
  Models_disease_asserted: WBDOannot00001202
    WBDOannot00001203
  Molecular_info: Corresponding_CDS (13)
    Corresponding_CDS_history: T21C12.1a:wp227
      T21C12.1a:wp239
      T21C12.1g:wp275
    Corresponding_transcript (14)
    Other_sequence (51)
    Associated_feature (25)
  Experimental_info: RNAi_result: WBRNAi00090257 Inferred_automatically: RNAi_primary
      WBRNAi00053708 Inferred_automatically: RNAi_primary
      WBRNAi00089728 Inferred_automatically: RNAi_primary
      WBRNAi00066348 Inferred_automatically: RNAi_primary
      WBRNAi00027895 Inferred_automatically: RNAi_primary
      WBRNAi00000954 Inferred_automatically: RNAi_primary
      WBRNAi00090099 Inferred_automatically: RNAi_primary
      WBRNAi00018961 Inferred_automatically: RNAi_primary
      WBRNAi00089939 Inferred_automatically: RNAi_primary
      WBRNAi00006214 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1283
      Expr15907
      Expr1027570
      Expr1032855
      Expr1157259
      Expr1200291
      Expr2017881
      Expr2036017
      Marker2
      Marker19
    Drives_construct: WBCnstr00001626
      WBCnstr00001627
      WBCnstr00006881
      WBCnstr00010191
      WBCnstr00019381
      WBCnstr00020581
      WBCnstr00034153
      WBCnstr00042588
    Construct_product: WBCnstr00001627
      WBCnstr00006881
      WBCnstr00016180
      WBCnstr00019381
      WBCnstr00020010
      WBCnstr00020581
      WBCnstr00021428
      WBCnstr00034153
    Antibody: WBAntibody00000613
      WBAntibody00001987
    Microarray_results (88)
    Expression_cluster (187)
    Interaction (31)
    WBProcess: WBbiopr:00000010
  Map_info: Map: III Position: 3.35021 Error: 0.089636
    Well_ordered
    Positive: Inside_rearr: nDf40
        mT1
      Positive_clone: T21C12 Person_evidence: WBPerson39
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 73
        86
        589
        3249
      Multi_point (55)
      Pos_neg_data: 3242
        3250
        3251
  Reference (138)
  Remark: Sequence connection from [Bamber BA]
  Method: Gene