WormBase Tree Display for Gene: WBGene00006831

WBGene00006831 SMap: S_parent: Sequence: C52E12
  Identity: Version: 1
    Name: CGC_name: unc-104 Person_evidence: WBPerson261
      Sequence_name: C52E12.2
      Molecular_name: C52E12.2a
        C52E12.2a.1
        CE48050
        C52E12.2b
        CE47855
        C52E12.2a.2
        C52E12.2b.1
      Other_name: klp-1
        CELE_C52E12.2 Accession_evidence: NDB BX284602
      Public_name: unc-104
    DB_info: Database: AceView gene 2H299
        WormQTL gene WBGene00006831
        WormFlux gene WBGene00006831
        NDB locus_tag CELE_C52E12.2
        Panther gene CAEEL|WormBase=WBGene00006831|UniProtKB=P23678
          family PTHR24115
        NCBI gene 174144
        RefSeq protein NM_001026870.7
            NM_171017.10
        SwissProt UniProtAcc P23678
        UniProt_GCRP UniProtAcc P23678
        OMIM gene 601255
            603060
            605995
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143874
    Allele: WBVar00274935 Inferred_automatically: From strain object: JC153
      WBVar00241551
      WBVar00241614
      WBVar00241613
      WBVar00144621
      WBVar02158259
      WBVar01307364
      WBVar01499702
      WBVar02141295
      WBVar02141296
      WBVar02141297
      WBVar00317942
      WBVar00317944
      WBVar01934875
      WBVar02018016
      WBVar02002805
      WBVar00092185
      WBVar00104544
      WBVar02147279
      WBVar02147280
      WBVar02147281
      WBVar02147282
      WBVar01559595
      WBVar01498435
      WBVar00173010
      WBVar00173011
      WBVar00104560
      WBVar00173013
      WBVar00173014
      WBVar00173015
      WBVar00173016
      WBVar00173018
      WBVar00173019
      WBVar00173020
      WBVar00321639
      WBVar00225729
      WBVar00741485
      WBVar00741486
      WBVar00741487
      WBVar00741488
      WBVar00741489
      WBVar00741490
      WBVar01902574
      WBVar00741491
      WBVar00741492
      WBVar00741493
      WBVar00741494
      WBVar00741495
      WBVar00741496
      WBVar00741497
      WBVar00741498
      WBVar00741499
      WBVar00741500
      WBVar00741501
      WBVar00741502
      WBVar00741503
      WBVar00741504
      WBVar00741505
      WBVar00741506
      WBVar00741507
      WBVar00741508
      WBVar00741509
      WBVar00741510
      WBVar01720160
      WBVar00241516
      WBVar00741511
      WBVar00741512
      WBVar01720161
      WBVar01720162
      WBVar00741513
      WBVar01720163
      WBVar00741514
      WBVar01720164
      WBVar00741515
      WBVar01473655
      WBVar00741516
      WBVar01473656
      WBVar01720165
      WBVar00741517
      WBVar01473657
      WBVar00225816
      WBVar00741518
      WBVar01473658
      WBVar00741519
      WBVar01473659
      WBVar00741520
      WBVar01826593
      WBVar00741521
      WBVar00741522
      WBVar00316263
      WBVar00741523
      WBVar00741524
      WBVar00143874
      WBVar00369308
      WBVar00369309
      WBVar00741525
      WBVar01604113
      WBVar00369310
      WBVar00241554
      WBVar00741526
      WBVar00741527
      WBVar00369311
      WBVar00741528
      WBVar00369312
      WBVar00741529
      WBVar00369313
      WBVar00741530
      WBVar00369314
      WBVar01783974
      WBVar00741531
      WBVar00369315
      WBVar00741532
      WBVar00369316
      WBVar00369317
      WBVar00741533
      WBVar00741534
      WBVar01916773
      WBVar00369318
      WBVar00369319
      WBVar00741535
      WBVar00369320
      WBVar00741536
      WBVar00369321
      WBVar00741537
      WBVar01400145
      WBVar00369322
      WBVar00741538
      WBVar02147424
      WBVar00741539
      WBVar00369323
      WBVar02147425
      WBVar02084809
      WBVar00369324
      WBVar00741540
      WBVar00369325
      WBVar00741541
      WBVar00741542
      WBVar00369326
      WBVar00369327
      WBVar00741543
      WBVar00741544
      WBVar00369328
      WBVar00741545
      WBVar00369329
      WBVar00741546
      WBVar00369330
      WBVar00741547
      WBVar00369331
      WBVar00225905
      WBVar00369332
      WBVar00741548
      WBVar00369333
      WBVar00741549
      WBVar00741550
      WBVar00369334
      WBVar00369335
      WBVar00741551
      WBVar00741552
      WBVar00369336
      WBVar00741553
      WBVar00369337
      WBVar00741554
      WBVar00369338
      WBVar00741555
      WBVar00741556
      WBVar00741557
      WBVar00741558
      WBVar00741559
      WBVar00741560
      WBVar00741561
      WBVar00741562
      WBVar01626662
      WBVar01626663
      WBVar00741563
      WBVar01626664
      WBVar00298216
      WBVar00741564
      WBVar01626665
      WBVar01666165
      WBVar00741565
      WBVar01666166
      WBVar01626666
      WBVar00741566
      WBVar00741567
      WBVar01626667
      WBVar01910592
      WBVar00234617
      WBVar01494487
      WBVar00090771
      WBVar01642026
      WBVar00551151
      WBVar00319808
      WBVar00319810
      WBVar01393743
      WBVar00314540
      WBVar00249846
      WBVar02144457
      WBVar01250539
      WBVar02144470
      WBVar01538248
      WBVar02144471
      WBVar01438338
      WBVar01438340
      WBVar01438341
      WBVar01438344
      WBVar01438345
      WBVar01493975
      WBVar01438346
      WBVar00308784
      WBVar01438347
      WBVar01438348
      WBVar01405210
      WBVar01477610
      WBVar01477611
      WBVar00225295
      WBVar02130179
      WBVar02130180
      WBVar02130181
      WBVar01374878
      WBVar02130182
      WBVar01766338
    Possibly_affected_by: WBVar02157549
      WBVar02157550
      WBVar02157551
      WBVar02157552
      WBVar02157553
    Legacy_information: L e1265 : severe coiler; e1265/Df probably lethal. ES3 ME0. NA1.
      See also e2184
      [C.elegansII] e1265 : severe coiler; Ric; defects in neuroanatomy; poor response to dauer pheromone;abnormal transport of synaptic vesicles. e1265/Df probably lethal. ES3 ME0. OA>5: rh43(viable, severe), rh142 (sublethal), ut60 (lethal, arrest as coiler), ut104, e2184::Tc1,rh1016, rh1017. Cloned: >30 kb gene, 6 kb transcript, encodes 1584 aa kinesin family protein. [Otsuka et al. 1991; Hall and Hedgecock 1991; Nguyen et al. 1995; DD; NJ]
      [Siddiqui SS]related to kinesin like protein by sequence similarity.
    Strain (19)
    RNASeq_FPKM (74)
    GO_annotation (81)
    Ortholog (51)
    Paralog (19)
    Structured_description: Concise_description: unc-104 encodes a kinesin-like motor protein homologous to human axonal transporter of synaptic vesicles (ATSV, OMIM: 601255); UNC-104 is required for anterograde axonal transport of synaptic vesicles as well as differentiation of pre- and postsynaptic domains at inhibitory neuromuscular junctions; UNC-104 is expressed solely in neurons; UNC-104 retrograde movement is regulated by PTL-1/Tau, with which it physically interacts in vivo. Paper_evidence: WBPaper00001424
            WBPaper00005798
            WBPaper00038442
          Curator_confirmed: WBPerson1843
          Date_last_updated: 09 Aug 2011 00:00:00
      Automated_description: Enables cytoskeletal protein binding activity; phosphatidylinositol phosphate binding activity; and plus-end-directed microtubule motor activity. Involved in several processes, including chemical synaptic transmission; regulation of cellular component organization; and regulation of cellular localization. Located in axon; presynapse; and somatodendritic compartment. Expressed in epithelial cell; muscle cell; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of the nervous system (multiple); carcinoma (multiple); and neuropathy (multiple). Is an ortholog of human KIF1A (kinesin family member 1A). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (12)
  Molecular_info: Corresponding_CDS: C52E12.2a
      C52E12.2b
    Corresponding_CDS_history: C52E12.2a:wp93
      C52E12.2b:wp93
    Corresponding_transcript: C52E12.2a.1
      C52E12.2a.2
      C52E12.2b.1
    Other_sequence (59)
    Associated_feature (12)
  Experimental_info: RNAi_result (12)
    Expr_pattern (15)
    Drives_construct (41)
    Construct_product (42)
    Antibody: WBAntibody00000733
      WBAntibody00002213
    Microarray_results (29)
    Expression_cluster (225)
    Interaction (134)
    Anatomy_function: WBbtf0455
      WBbtf0456
      WBbtf0457
  Map_info: Map: II Position: 0.210467 Error: 0.00612
    Well_ordered
    Positive: Inside_rearr: mC6
        mDf18
      Positive_clone: C47A5
        C52E12 Inferred_automatically: From sequence, transcript, pseudogene data
        DD#LAJ8
    Negative: Outside_rearr: mcDf1
    Mapping_data: 2_point: 948
        3709
        6169
      Multi_point (16)
      Pos_neg_data: 544
        548
        554
        597
        619
        4514
        4221
        4222
        8958
        10270
  Reference (308)
  Remark: yk16g10.3 removed from sequence list. sdm 11/00
    klp-1 is the same gene as unc-104 and was therefore merged into unc-104
  Method: Gene